Research ArticleOpen accessEvery word in the titleEvaluation of Antiviral Activity of Different Medicinal Plants against Newcastle Disease VirusKhaldoun J. Al-HadidNewcastle Disease (ND) is a highly contagious viral disease that has a tremendous negative impact on the poultry industry worldwide. Plant extracts were prepared from five different medicinal plants and applied against Newcastle Disease Virus (NDV) to evaluate the antiviral replication in Specific Pathogen-Free (SPF) chicken embryos. Three dilutions from each plant extract were prepared and mixed with a fixed … …American Journal of Agricultural and Biological Sciences, Vol. 11, Issue 4 · 1 Nov 2016 · 8,871 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDetection of Hepatitis C Virus Resistant Mutants in the era of Direct Acting AntiviralsLivia Maria Gonçalves Rossi, Paula RahalHepatitis C Virus (HCV) infects millions of people and represents an important public health problem in different regions of the world. Drug resistance is a major challenge for HCV-infection related control. Importantly, the arrival of a plethora of novel, more powerful drugs has revolutionized the field of HCV treatment. Here, we discuss the relevance of identification of HCV resistant mutants … …American Journal of Infectious Diseases, Vol. 10, Issue 4 · 7 Jan 2015 · 6,429 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleDietary Flavonols With Antiviral Efficacy: Safety and Regulatory ConcernsTanisha Parvez, Tanveer Yaqub, Shama Parveen, Mohammad Khalid ParvezGlobally, a variety of pharmacologically-active plant or natural products are commonly consumed as health-protective dietary supplements. These are marketed as crude formulations, isolated metabolites, multi-vitamins, essential amino acids, unsaturated fatty acids and minerals. Of these, pharmacologically-active flavonols like rutin, quercetin, kaempferol, myricetin, isorhamnetin are the most consumed dietary supplements. In addition to their broad-spectrum therapeutic benefits, these are also known … …American Journal of Pharmacology and Toxicology, Vol. 20, Issue 1 · 19 Apr 2026 · 1,866 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAntiviral and Quantitative Structure Activity Relationship Study for Dihydropyridones Derived from CurcuminBahjat A. Saeed, Kawkab Y. Saour, Rita S. Elias, Najim A. Al-MasoudiProblem statement: Pyridones are known to have variety of biological activities like antitumor, antibacterial, anti-inflammatory and antimalarial activities. This study presents antiviral evaluation of dihydropyridones derived from curcumin, as well as curcumin for comparison. Approach: The compounds evaluated for their in vitro antiviral activities against the viruses: HIV-1, Bovin viral Diarrhea, Yellow Fever, Reovirus 1, Herpesvirus 1, Vaccinia, Vescular Stomatitis, … …American Journal of Immunology, Vol. 6, Issue 2 · 30 Jun 2010 · 8,151 accessesView PDFCite
Research ArticleOpen accessIn the keywordsRibavirin Plus Therapy in Covid-19-A Single-Center ExperienceBudha Oinam Singh, Gaurav Chikara, Prasan Kumar Panda et al.COVID-19 infection has a similar clinical spectrum of disease presentation such as SARS and MERS in the past. These led to the assumption of the possibility to treat COVID-19 infection with antivirals which had been used to treat SARS and MERS. A retrospective analysis was done in symptomatic adult patients of COVID-19 infection to explore whether ribavirin antiviral combinations reduce … …American Journal of Pharmacology and Toxicology, Vol. 18, Issue 1 · 25 Jul 2023 · 8,610 accessesView PDFCite
Case ReportOpen accessIn the keywordsHepatitis B-Related Mononeuritis MultiplexBudha Charan Singh, Vinay N Gowda, Prasan Kumar PandaHepatitisB Virus (HBV) infection can present with varied multisystem manifestationsinvolving the skin, kidneys, blood, and nervous system. We report a 57-year-oldman with HBV-related mononeuritis multiplex who had symptoms of multiplesensory-motor axonal polyneuropathies. He was evaluated for his neuropathy withnerve conduction studies and a sural nerve biopsy that revealed necrotizingsmall-vessel vasculitis. He also hadan acute liver injury. He was started on … …American Journal of Infectious Diseases, Vol. 18, Issue 4 · 16 Nov 2022 · 5,719 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAssociation of Remdesivir with Poor Clinical Outcomes in COVID-19-A Single Center ExperienceRajat Ranka, Arjun, Prasan Kumar Panda et al.The need for an antiviral against COVID-19 prompted clinical trials worldwide and based on initial promising trends, remdesivir was widely used, including in India (compassionate use). Subsequent trials have been conflicting in their results and the utility of the drug has been widely debated. This is a record-based retrospective cohort study in a 1000-bedded government teaching hospital in North India. … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 3 Jun 2022 · 7,210 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCurrent Advances in Zika Virus Transmission: Urgency for Effective Therapeutics and PreventionYash Raj, Swatantra Kumar, Amrita Haikerwal et al.Global emergence of Zika Virus (ZIKV) with prevalent outbreaks has been reported in numerous countries of South America, Central America and the Caribbean region. According to recent World Health Organization (WHO)-ZIKV situation report, 84 countries/territories/subnational areas represented with established mosquito-borne transmission of ZIKV. As of 10 August 2017, cumulative Zika cases and congenital syndrome associated with Zika virus reported by … …American Journal of Infectious Diseases, Vol. 13, Issue 2 · 2 Oct 2017 · 7,798 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAntimicrobial Effects of 1-Monocaprylin and 1-Monocaproin Through in vitro Growth Inhibition and Molecular Docking StudiesPalaniappan Maheswari, Kasthuri Revathi1-monocaproin and 1-monocaprylin synthesized through a novel process by the chemical reaction of glycidol and their respective fatty acids with copper acetate as the catalyst possessed the amphiphilic property. 1- monoacyl glycerols synthesized were found to exhibit antibacterial, antifungal, anti parasitic and antiviral properties. 1-monocaproin and 1-monocaprylin were able to show their antibacterial effect by inhibiting the growth of the … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 3 · 19 Aug 2017 · 7,970 accessesView PDFCite