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6 results for “Anticonvulsant Activity”
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Research ArticleOpen accessPhrase in the titleAnticonvulsant Activity of Hydroalcoholic Phoenix dactylifera Fruit Extract and Pimpinella anisum Oil in MiceSameh Mohamed Mostafa EL-Nabtity, Ahmed Shaban Abdelaziz, Manar Salah Moselhi, Mario GiorgiEpilepsy is a group of long-term neurological disorders characterized by epileptic seizures. The present study sought to investigate the anticonvulsant and neuroprotective Activity of Hydroalcoholic Phoenix dactylifera fruit extract (HAPD) and Pimpinella Anisum Oil (PAO) against Pentylenetetrazole (PTZ) and Maximal Electric Shock (MES) induced a seizure in mice. Mice groups were treated with HAPD1000 mg/kg, PAO 4 ml/kg. The onset … …American Journal of Animal and Veterinary Sciences, Vol. 14, Issue 2 · 25 May 2019 · 7,590 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleOn Application of Carhart Atom Pairs to Predict Anticonvulsant ActivityAlan Talevi, Julian J. Prieto, Luis E. Bruno-Blanch, Eduardo CastroAbout 50 million people in the world suffer from epilepsy, especially in childhood, adolescence and old age. Available treatment fails to control epilepsy in up to 30% of affected people. In developing countries, however, the amount of patients that do not receive adequate treatment climbs up to 75%. Moreover, the new generation of antiepileptic drugs (AEDs) causes important central and … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,857 accessesView PDFCite
Research ArticleOpen accessIn the keywordsβ-Naphthalene Incorporated Thiazole-5-Carboxamides/Thiazole -5- Ketones: Design, Synthesis and Anticonvulsant Screening against Two Seizure ModelsMohammed Faiz Arshad, Faisal Al-Otaibi, Gulam Mustafa et al.A bunch of β-naphthalene incorporated thiazole-5-carboxamides/thiazole -5- ketones (7a-7o& 8a-8e) were prepared by reacting 4-methyl-2-(naphthalen-2-yl)thiazole-5-carbonyl chloride with appropriate amines. Structures of all the compounds were explained by elemental analysis, FT-IR, 1H NMR and mass spectral data. The compounds were evaluated for their anticonvulsant activity employing MES and chemoshock (scPTZ) seizure tests. Neurotoxicity was also assessed. Majority of these compounds exhibited … …American Journal of Pharmacology and Toxicology, Vol. 14, Issue 1 · 29 Aug 2019 · 7,494 accessesView PDFCite
Research ArticleOpen accessIn the keywordsANTICONVULSANT AND NEUROTOXICITY EVALUATION OF SOME NEWLY SYNTHESIZED THIAZOLYL COUMARIN DERIVATIVESM. Faiz Arshad, Nadeem Siddiqui, Ahmed Elkerdasy et al.The present series of compounds were synthesized with the aim to develop newer anticonvulsant agents that are comparatively more efficacious and safer than the currently used anticonvulsant agents. Various thiazolyl coumarins were synthesized by the reaction of 3-(bromoacetyl)-2H-chromen-2-one with different substituted aryl thiourea. The structures of the synthesized compounds were confirmed by spectral data and elemental analyses. Compounds were tested … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 2 · 26 Mar 2014 · 7,676 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Phenylbutazone on Pentylenetetrazole-Induced Seizure in MiceKhayatnouri MirhadiProblem statement: The Cyclooxygenases (COXs), the key enzymes that convert arachidonic acid to Prostaglandins (PGs), had been implicated in physiological and pathophysiological functions in the CNS. Non-Stesoidal Anti-Inflammatory Drugs (NSAIDs), COX inhibitors, were used largely to treat febrile condition, pain state and for prevention of and therapeutics of many diseases. However the role of PGs and NSAIDs in the seizure … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 13 Dec 2011 · 7,675 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Nifedipine on Dichlorvos-Induced Seizure in MiceKhayatnouri MirhadiProblem statement: Dichlorvos a synthetic organophosphate poisons is the property of insecticide. These toxins as insecticides in agriculture and medicine for animals and the destruction of ectoparasites can be used. Studies have shown that Dichlorvos creation seizure effects in different animals. Nifedipine, dihydropyridine calcium channel blockers, widely used for treatment of cardiovascular diseases. Studies have shown that the calcium channel … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 2 · 17 Sep 2011 · 8,054 accessesView PDFCite