3 results for “Acute Renal Damage”

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Research ArticleOpen accessIn the keywordsEvaluation of the Renoprotective Effects of Valsartan in Methotrexate-Induced Acute Kidney Injury in RatsDina KutbiMethotrexate (MTX) is a widely used chemotherapeutic agent known for its nephrotoxic effects, which can lead to acute kidney injury in hospitalized patients. However, the mechanism by which MTX induces nephrotoxicity is not entirely clear, but it is believed to involve oxidative stress and direct toxic effects on renal tubules. Valsartan, an angiotensin II receptor blocker, has been shown to … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 4 May 2024 · 4,571 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEffect of Chromium(VI) on Serum Iron and Removal of its Toxicity by Combining Deferasirox and Deferiprone Chelators in RatsS. Jamil A. Fatemi, Marzieh Iranmanesh, Faezeh Dahooee BaloochThe present research is aimed to characterize the potential efficiency of two chelators after chromium(VI) administration for 60 days following two doses of 15 and 30 mg kg-1 chromium(VI) per body weight daily to male rats. However, the hypothesis that the two chelators might be more efficient as combined therapy than as single therapy in removing chromium(VI) from bood serum … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 30 Oct 2013 · 7,152 accessesView PDF Cite

Case ReportOpen accessAll words, across the recordAn Unusual Case of Leptospirosis Presenting as Glomerulonephritis With CrescentsFelipe Guedes Bezerra, Ana Flávia de Holanda Veloso, Yago Sucupira Amaral et al.Leptospirosis is a zoonosis caused by the spirochete Leptospira, which commonly affects the kidneys. Varied renal findings, most commonly tubulointerstitial nephritis, are found in human kidney biopsies and in vivo models. Remarkably, glomeruli are usually spared in this disease. However, some cases report evidence of glomerular damage. We describe a case of leptospirosis with fibroepithelial crescents, a rare histopathological finding. …American Journal of Infectious Diseases, Vol. 22, Issue 1 · 6 Aug 2026 · 1,011 accessesView PDF Cite