6 results for “Acridine Orange (AO)”

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Research ArticleOpen accessIn the keywordsChemical Mutagenesis for Improvement of Production of a Biologically Active Extracellular Polymeric Substance by Halomonas xianhensis SUR308Jhuma Biswas, Amal K. PaulA moderately halophilic bacterium, Halomonas xianhensis SUR308 (Genbank Accession No. KJ933394) isolated from solar saltern of Surala, Odisha, India was found to produce significant amount of a biologically active extracellular polymeric substances (EPS). Under optimized cultural conditions, the strain was able to produce 7.05 g L-1 of EPS after 8 days of incubation under shake culture. To enhance the EPS … …Current Research in Microbiology, Vol. 7, Issue 1 · 1 Apr 2016 · 15,926 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsP-Glycoprotein-Mediated Efflux and Drug Sequestration in Lysosomes Confer Advantages of K562 Multidrug Resistance Sublines to Survive Prolonged Exposure to Cytotoxic AgentsNathupakorn Dechsupa, Samlee MankhetkornProblem statement: Cellular drug resistance to anticancer agents is major obstacle in cancer chemotherapy and the mechanisms by which these MDR cells possess for protecting themselves to survive prolonged exposure to cytotoxic agents still debating. The study aimed to clarify the role of P-glycoprotein (Pgp) and enhanced drug sequestration in lysosomes to confer the multidrug resistance K562 cells with varied … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 7,508 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe interplay between Cadmium and Zinc Induced Developmental Perturbations and Apoptosis in Daphnia MagnaNaima Hamid, Siti Nur Airina Binti Ibrahim et al.Assessing combined toxicity provides a realistic and comprehensive approach to determining toxicological effects in aquatic species under environmentally relevant conditions. This study was conducted to understand the effects of single and combined metal mixtures on freshwater flea and Daphnia magna. Environmentally Relevant Concentrations (ERCs) of Cadmium (Cd) and Zinc (Zn) at a low dose (10μg/L) and high dose (30 μg/L) … …American Journal of Environmental Sciences, Vol. 21, Issue 1 · 11 Jun 2025 · 6,021 accessesView PDF Cite

Research ArticleOpen accessIn the abstractInhibition Effect of Walnut Leaf Polysaccharide on HepG2 Cells in vitroShuqing Yang, Haifang Xiao, Shuyan Yu et al.In this study, the effect of Walnut Leaf Polysaccharides (WLP) on human liver tumor HepG2 cells was investigated. The results showed that WLP had dose-dependent and time-dependent inhibitory effects on HepG2 cell viability. Typical apoptosis characteristics were observed in WLP-treated HepG2 cells through 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethyl-benzimidazolyl-carbocyanine iodide (DAPI) staining and Acridine Orange (AO)/Ethidium Bromide (EB) dual staining. Meanwhile, significant decrease in Mitochondrial … …American Journal of Biochemistry and Biotechnology, Vol. 15, Issue 4 · 29 Oct 2019 · 7,316 accessesView PDF Cite

Research ArticleOpen accessIn the abstractQuercetin Iron (III) Complex Enhances Radiation-Induced Cell Death in Human Erythroleukemic Cell Lines by Increasing the Generation of Intracellular ROSJiraporn Kantapan, Krai Daowtak, Kachaporn Gateprayoon et al.Quercetin iron (III) complex (IronQ) is a paramagnetic agent which exhibits several biological effects. Despite extensive studies about quercetin metal complex, the role of complexes to enhance the effect of radiation still remains unexplored. To this end, we determined whether and how IronQ sensitizes cancer cells to Ionizing Radiation (IR). Doxorubicin resistant leukemic cells (K562/Adr) and their parental cell lines … …American Journal of Applied Sciences, Vol. 14, Issue 1 · 16 Jan 2017 · 8,068 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCytogenetic Analysis among Train Depot Workers Exposed to Total Volatile Organic CompoundsNormah Awang, Siti Adillah Isah, Asmah HamidOccupational exposure to toxic chemicals such as Total Volatile Organic Compounds (TVOC) from diesel engine exhaust implicates genotoxic risk. The objective of this study was to determine the DNA damage among KL Sentral depot workers exposed to TVOC by means of cytogenetic analysis. Data were obtained partially from disseminated questionnaires and buccal cells samples were collected from a total of … …OnLine Journal of Biological Sciences, Vol. 15, Issue 2 · 12 Jun 2015 · 7,446 accessesView PDF Cite