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77 results for “Disease Progression”
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Research ArticleOpen accessIn the abstractA Model for the CD4 Cell Counts in an HIV/AIDS Patient and its Application in Treatment InterventionsRichard O. Simwa, Joseph Y.T. MugishaThe number of CD4 white blood cells has been established as an important clinical marker of disease progression to acquired immunodeficiency syndrome (AIDS) for persons infected with human immunodeficiency virus (HIV). The number of CD4 cells per unit volume is expected to decrease with time since infection by the virus. However on introduction of treatment interventions, the process is expected … …American Journal of Infectious Diseases, Vol. 1, Issue 1 · 31 Mar 2005 · 6,842 accessesView PDFCite
Literature ReviewOpen accessAll words, across the recordMicroRNAs in Atherosclerosis: Key Players, Diagnostic Potential, and Therapeutic OpportunitiesAnastasia V Poznyak, Stanislav Anatolievich Antonov, Ulyana V. Rozhkova et al.Atherosclerosis is a significant contributor to cardiovascular diseases, often progressing silently over many years before clinical symptoms manifest. The multifaceted pathogenesis of atherosclerosis, involving processes such as endothelial dysfunction and inflammation, presents challenges in early diagnosis and effective treatment. MicroRNAs (miRNAs), a class of non-coding RNA molecules with post-transcriptional gene regulation abilities, have emerged as potential key players in atherosclerosis … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 25 Jul 2026 · 740 accessesView PDFCite
Review ArticleOpen accessAll words, across the recordObesity as a Predisposing Factor for AtherosclerosisAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina et al.Obesity stands as a pressing global health concern, associated with a myriad of threats to human well-being and longevity. Within the scope of this review, we zero in on how obesity impacts the onset of atherosclerosis, given its well-established link as a risk factor in its development. The progression of atherosclerosis is notably hastened by obesity, driven by a host … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 23 Jul 2025 · 2,737 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordPrognosis of Dementia Using Early Fusion Approach with Digital Clock Drawing and Trail-Making TestsShridevi Karande, Vrushali KulkarniDementia poses a substantial global public health challenge. Emerging evidence suggests that COVID-19's neurological impact may aggravate dementia incidences. Timely recognition and management can significantly decelerate dementia progression and enhance affected individuals' quality of life. In the realm of cognitive assessment, the Clock Drawing Test (CDT) and Trail-Making Test (TMT) stand as prominent tools. Existing research predominantly focuses on the … …Journal of Computer Science, Vol. 20, Issue 8 · 10 Jun 2024 · 4,720 accessesView PDFCite
Review ArticleOpen accessAll words, across the recordCardiolipin in Pathology: Implications in AtherosclerosisAnastasia Vladimirovna Poznyak, Vasily Nikolaevich Sukhorukov, Anton Yuvenalievich Postnov et al.Mitochondria are cell organelles whose main role is to generate the energy needed for cell biochemical reactions via oxidative phosphorylation. Cardiolipin is a phospholipid that is present in the inner mitochondrial membrane and other energy-transducing membranes. Mitochondrial structure largely depends on cardiolipin, as it is involved in the biogenesis of mitochondrial cristae, folds in the inner mitochondrial membrane designed to … …OnLine Journal of Biological Sciences, Vol. 23, Issue 4 · 23 Sep 2023 · 4,792 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordAssociation of Remdesivir with Poor Clinical Outcomes in COVID-19-A Single Center ExperienceRajat Ranka, Arjun, Prasan Kumar Panda et al.The need for an antiviral against COVID-19 prompted clinical trials worldwide and based on initial promising trends, remdesivir was widely used, including in India (compassionate use). Subsequent trials have been conflicting in their results and the utility of the drug has been widely debated. This is a record-based retrospective cohort study in a 1000-bedded government teaching hospital in North India. … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 3 Jun 2022 · 7,210 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordVitamin D Supplements Tone Down the Progression of Atheromatous Plaque Formation in a Dose-Dependent MannerAhmed Farouk, Khalid M. Mohany, Magdy Algowhary et al.Hypovitaminosis D has a negative impact on the cardiovascular system. We performed the current study to investigate the expression of Vitamin D Receptor (VDR) in atherosclerotic human male aortas and to examine the effect of different doses of Vit. D supplementation on VDR expression in the aortas of male rats fed a High-Fat Diet (HFD). Human participants included 50 atherosclerotic … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 3 · 5 Oct 2021 · 6,724 accessesView PDFCite