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Research ArticleOpen accessIn the abstractPharmacophore Pattern Identification of Tachykinin Receptor Selective Peptide Agonists: Implications in Receptor SelectivityAnjali Dike, Indu R. Chandrashekaran, Anil K. Mantha et al.The mammalian tachykinin (TK) peptides and their three Neurokinin (NK1, NK2 and NK3) receptors represent an effector system with wide-ranging actions on neuronal, airway smooth muscle, mucosal, endothelial, immune, inflammatory and remodeling cell function. Recent clinical and preclinical data suggests the pathophysiological role of TKs in various diseases including asthma, emesis and depression. The TK-NK receptor interactions and overlapping functions … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 6,691 accessesView PDFCite
Research ArticleOpen accessIn the abstractDeciding Whether There is Statistical Independence or Not?Ramzi NasserThe study investigated how students assess statistical independence (SI). A sample of 98 students was available to the researcher. One group was probed on their understanding of statistical independence, a second group was given a proficiency test and a third group was presented a proof for statistical Independence. Interview data from the first two groups exposed student misconception on their … …Journal of Mathematics and Statistics, Vol. 3, Issue 3 · 30 Sep 2007 · 6,818 accessesView PDFCite
Research ArticleOpen accessIn the abstractCardiovascular Effect of Capparis spinosa Aqueous Extract. Part VI: in vitro Vasorelaxant EffectN. A. Zeggwagh, J. B. Michel, M. EddouksThe aim of this study was to investigate the in vitro vasorelaxanteffect of Capparis spinosa aqueous extract (CSAE) at a dose of 10 mg mL-1. Aortic rings isolated from normal wistar rats were used. The addition of CSAE during the plateau phase of contraction, induced by noradrenaline and KCl, produced a rapid relaxation. Incubation of aortic ring with CSAE during … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 3 · 30 Sep 2007 · 7,444 accessesView PDFCite
Research ArticleOpen accessIn the abstractCardiovascular Effect of Capapris spinosa Aqueous Extract in Rats. Part II: Furosemide-like Effect of Capparis spinosa Aqueous Extract in Normal RatsN.A. Zeggwagh, J. B. Michel, T. Sulpice, T. M. EddouksThe purpose of this study was to examine the diuretic effect of the aqueous extract of Capparis spinosa (Cs) at a dose of 500 mg kg-1 h-1 in normal rats. The aqueous extract was administred intravenously and the diuresis was followed within four hours after starting the treatment. Intravenous administration of aqueous Cs extract produced a significant increase on diuresis … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 3 · 30 Sep 2007 · 7,197 accessesView PDFCite
Research ArticleOpen accessIn the abstractCardiovascular Effect of Capparis spinosa Aqueous Extract. Part III: Antihypertensive Effect in Spontaneously Hypertensive RatsZeggwagh Naoufel Ali, Mohamed Eddouks, Jean Baptiste Michel et al.This study aims to evaluate the hypotensive activity of Capparis spinosa aqueous extract (CSAE) in spontaneously hypertensive (SH) rats. CSAE was lyophilised and administrated daily at a dose of 150 mg kg-1 for 20 days. CSAE administration produced a significant reduction in systolic blood pressure after eight days of oral administration (p 0.05) after 20 days of oral administration. We … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 3 · 30 Sep 2007 · 9,327 accessesView PDFCite
Research ArticleOpen accessIn the abstractColourimetric Determination of Phospholipase Activities in Balamuthia mandrillarisSyed Razi HaiderBalamuthia mandrillaris is a recently identified protozoan pathogen that can cause fatal granulomatous encephalitis however the pathogenesis and pathophysiology associated with Balamuthia encephalitis remain unclear. We have recently isolated B. mandrillaris from a 33-years old male who died of encephalitis. Using this isolate, we demonstrated for the first time that B. mandrillaris exhibited phospholipase activities. More specifically, B. mandrillaris exhibited … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 3 · 30 Sep 2007 · 6,771 accessesView PDFCite
Research ArticleOpen accessIn the abstractLimits and Opportunities for Autonomous User Organisations in Denmark and SwedenJørgen AnkerThe Nordic welfare states generally support and facilitate the formation of civil society organisations and they provide relatively good opportunities for participation and interest mediation. The Nordic welfare states are also recognised for their efforts to limit social inequality and for seeking to provide acceptable living conditions even for the most vulnerable and excluded groups. This article focuses on the … …Journal of Social Sciences, Vol. 3, Issue 2 · 30 Jun 2007 · 7,752 accessesView PDFCite
Research ArticleOpen accessIn the abstractNaloxone benzoylhydrazone activates Extracellular Signal-Regulated Protein Kinases and modulates Nociceptin Opioid Peptide Receptor activityDeepak R. Thakker, Ghazi F. Altememi, Chitra D. Mandyam et al.Naloxone benzoylhydrazone (NalBzoH) is often used as a nociceptin opioid peptide (NOP) receptor antagonist. However, NalBzoH is also a mixed μ antagonist/κ and δ opioid agonist and its actions at the NOP receptor range from an antagonist to partial agonist, depending on the effector response/system studied. We now report that NalBzoH activates endogenously expressed κ3 opioid, but not NOP, receptors … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,549 accessesView PDFCite
Research ArticleOpen accessIn the abstractAqueous Extract of Inonotus bliquus (Fr.) Pilat (Hymenochaetaceae) Significantly Inhibits the Growth of Sarcoma 180 by Inducing ApoptosisCaifa Chen, Weifa Zheng, Xiaowen Gao et al.Inonotus obliquus (Fr.) Pilat (Hymenochaetaceae) has been widely used as a folk medicine to treat various cancers in Russia, Poland and most of Baltic countries for literally more than four centuries. However, in spite of its therapeutic significance for cancers, this fungus has not been studied systematically for the mechanisms of antitumor activity. In this study, we report the effects … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 1 · 31 Mar 2007 · 21,110 accessesView PDFCite
Research ArticleOpen accessIn the abstractWound Healing Process of Uncomplicated “Rusterholz” Ulcer, Following Treatment by Wooden Block and Hoofgel® in Bovine Hoof: Histopathological AspectsH. Azarabad, I. Nowrouzian, E. Soleymani et al.A broad and very detailed histopathological knowledge on cutaneous wound healing particularly in human skin is available, but few studies have documented this event in bovine claw sole ulcers. It seems the mechanism of wound healing might be basically the same followed by second intention healing which is finished in a period of time by formation of granulation tissue in … …American Journal of Animal and Veterinary Sciences, Vol. 1, Issue 2 · 31 Dec 2006 · 7,847 accessesView PDFCite