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Author

Chitra D. Mandyam

The Scripps Research Institute, United States
1 article in our journals

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Research ArticleOpen accessNaloxone benzoylhydrazone activates Extracellular Signal-Regulated Protein Kinases and modulates Nociceptin Opioid Peptide Receptor activityDeepak R. Thakker, Ghazi F. Altememi, Chitra D. Mandyam et al.Naloxone benzoylhydrazone (NalBzoH) is often used as a nociceptin opioid peptide (NOP) receptor antagonist. However, NalBzoH is also a mixed μ antagonist/κ and δ opioid agonist and its actions at the NOP receptor range from an antagonist to partial agonist, depending on the effector response/system studied. We now report that NalBzoH activates endogenously expressed κ3 opioid, but not NOP, receptors … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,549 accessesView PDFCite