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Research ArticleOpen accessIn the abstractEpstein-Barr Virus Infection as A Trigger of Autoimmune Hepatitis: Case ReportD. Cabibi, S. Scaduti, M. Cacciatore, F. Di GaudioThe study underlines the importance of the differential diagnosis between primary Epstein-Barr virus EBV associated hepatitis with features of autoimmunity, in which there is a direct pathogenetic role of the virus, and EBV related autoimmune hepatitis, in which EBV could act as the trigger of the immune-mediated damage with probable differences between the two conditions with regard to the prognosis … …American Journal of Infectious Diseases, Vol. 4, Issue 3 · 30 Sep 2008 · 6,959 accessesView PDFCite
Research ArticleOpen accessIn the abstractTrace Metals Co-Toxicity in Hard Body Structures of Liza klunzingeri (Mugilidae: Perciformes) Mullet FishA.H. Bu-Olayan, B.V. Thomas, S.M.H. Al-HusainiThe possibility of inorganic pollutants causing stress to the marine ecosystem instigated us to conduct eco-toxicological tests on the predominant trace metals (Cu, Zn, Pb and V) in commercial important fish. Among the four metals, V had the lowest observed effect concentration (LOEC: LC15) at 6.3 µg L-1. Toxicity tests (96 h) using Multi factor Probit analysis revealed V (6.3 … …American Journal of Environmental Sciences, Vol. 4, Issue 4 · 31 Aug 2008 · 6,515 accessesView PDFCite
Research ArticleOpen accessIn the abstractHydrochemical Differentiation of Salinisation Process of the Water in Endoreic Semi-Arid Basin: Case of Rémila Basin, AlgeriaHouha Belgacem, Kherici Nacer, Kachi Slimane, Valles VincentThe aim of this study is to determine and treat a hierarchical basis of the various mechanisms responsible for the space variation of the water quality in a endoreic semi-arid basin. The water chemistry showed a large variability in space and time. The total dissolved solid (TDS) in water increases from upstream to downstream due to the effect of the … …American Journal of Applied Sciences, Vol. 5, Issue 7 · 31 Jul 2008 · 7,310 accessesView PDFCite
Research ArticleOpen accessIn the abstractBridging from Cells to Cognition in Autism Pathophysiology: Biological Pathways to Defective Brain Function and PlasticityMatthew P. Anderson, Brian S. Hooker, Martha R. HerbertWe review evidence to support a model where the disease process underlying autism may begin when an in utero or early postnatal environmental, infectious, seizure, or autoimmune insult triggers an immune response that increases reactive oxygen species (ROS) production in the brain that leads to DNA damage (nuclear and mitochondrial) and metabolic enzyme blockade and that these inflammatory and oxidative … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 17,461 accessesView PDFCite
Research ArticleOpen accessIn the abstractPercentile Double Ranked Set SamplingAmer Ibrahim Al-Omari, Khalifa H. JaberIn this paper, percentile double ranked set sampling (PDRSS) method is suggested for estimating the population mean. The PDRSS method is compared with the simple random sampling (SRS), ranked set sampling (RSS), median ranked set sampling (MRSS) and the extreme ranked set sampling (ERSS) methods. When the underlying distribution is symmetric, it turns out that PDRSS produce unbiased estimators of … …Journal of Mathematics and Statistics, Vol. 4, Issue 1 · 31 Mar 2008 · 7,417 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuroprotection Afforded by GABA Against Oxygen-Glucose Deprivation-Induced Injury in Rat Cortical Brain Slices: An Hormetic Dose-Response EffectLorenzo Ricci, Massimo Valoti, Giampietro Sgaragli, Maria FrosiniThe aim of the present investigation was to assess neuroprotection exerted by GABA (100 nM-100 mM) in rat cortical brain slices subjected to oxygen-glucose deprivation and reoxygenation. Neuronal injury and neuroprotection were assessed by measuring the release of glutamate and lactate dehydrogenase and tissue water content. Results demonstrate that GABA exerted neuroprotective effects according to a U-shaped, hormetic-like, concentration-response curve, … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,168 accessesView PDFCite
Research ArticleOpen accessIn the abstractWhat is Xenohormesis?Joseph A. Baur, David A. SinclairPolyphenols such as resveratrol and quercetin, which are produced by stressed plants, activate sirtuin enzymes and extend the lifespan of fungi and animals, ostensibly by mimicking the beneficial effects of caloric restriction. This observation raises an interesting question: Why should foreign molecules that are non-nutritive and seemingly unrelated to any endogenous molecule modulate the same biochemical pathways that mediate the … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 10,391 accessesView PDFCite
Research ArticleOpen accessIn the abstracttNOX (ENOX2) Target for Chemosensitization-Low-Dose Responses in the Hormetic Concentration RangeD. James Morre, Sara Dick, Elena Bosneaga et al.An emerging concept of cancer chemotherapy is that of chemosensitization. Most often applied to the treatment of drug-resistance cancers, chemosensitization has utility when such cancers are rendered drug sensitive through treatment with the sensitizing agent. A particularly striking example of chemosensitization is that encountered with the synthetic isoflavene phenoxodiol where patients with taxane- and/or platinum-resistant ovarian carcinoma once again become … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,573 accessesView PDFCite
Research ArticleOpen accessIn the abstractHormetic Triggers for Intervention in Aging, Disease and TraumaJoan Smith SonnebornHormesis refers to the ability of a chemical or physical agent to condition the physiological state of an organism to tolerate stress with low doses of otherwise harmful agents. Evolutionary evidence shows that the survival and longevity of species hinge on their optimal ability to resist stress challenge. Hormesis is a potent strategy to stimulate latent repair processes to tolerate … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,898 accessesView PDFCite
Research ArticleOpen accessIn the abstractC-Terminal Region of Dengue Virus Nonstructural Protein 1 Is Involved in Endothelial Cell Cross-Reactivity via Molecular MimicryShu-Wen Wan, Chiou-Feng Lin, Mei-Chun Chen et al.Infection with dengue virus (DV) causes diseases ranging from self-limited dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome. Vascular leakage, thrombocytopenia and bleeding are the clinical manifestations associated with dengue hemorrhage. We previously showed that anti-DV nonstructural protein 1 (NS1) antibodies (Abs) cross-reacted with endothelial cells. The potential target proteins on endothelial cell surface recognized by anti-DV … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,564 accessesView PDFCite