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Author

David A. Sinclair

Harvard Medical School, United States
1 article in our journals

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Research ArticleOpen accessWhat is Xenohormesis?Joseph A. Baur, David A. SinclairPolyphenols such as resveratrol and quercetin, which are produced by stressed plants, activate sirtuin enzymes and extend the lifespan of fungi and animals, ostensibly by mimicking the beneficial effects of caloric restriction. This observation raises an interesting question: Why should foreign molecules that are non-nutritive and seemingly unrelated to any endogenous molecule modulate the same biochemical pathways that mediate the … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 10,386 accessesView PDFCite