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97 results for “Dose Dependent”
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Research ArticleOpen accessIn the abstractAnalgesic and Antioxidant Activity of the Hydromethanolic Extract of Mikania scandens (L.) Willd. LeavesS.M. Raquibul Hasan, Mariam Jamila, Muntasir Mamun Majumder et al.Problem statement: Mikania scandens (L.) Willd., a medicinal plant, is popularly used as herbal remedy for various ailments in Bangladesh. But the scientific basis for its medicinal use especially in pain and inflammation remains unknown. Therefore, the present study was designed to evaluate analgesic and antioxidant potential of the hydromethanol extract of the leaves of the plant. Approach: The analgesic … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 1 · 31 Mar 2009 · 12,547 accessesView PDFCite
Research ArticleOpen accessIn the abstractInfluence of Ionizing Radiation on Antioxidant Enzymes in Three Species of TrigonellaMuna M. Al-Rumaih, May M. Al-RumaihThe response of three species of Trigonella, namely, Trigonella stellata, Trigonella hamosa and Trigonella anguina to gamma irradiation stress was investigated with respect to antioxidant enzyme induction. When dry seeds were subjected to gamma rays (0, 40, 60, 80, 100 Krad) from a cobalt source 60Co at a dose rate of 233.5 rad/ min, a dose dependent increase in the … …American Journal of Environmental Sciences, Vol. 4, Issue 2 · 30 Apr 2008 · 8,414 accessesView PDFCite
Research ArticleOpen accessIn the abstractHormetic and Non-Hormetic Dose-Response Functions in Stress Effects on Memory and Synaptic Plasticity: Issues and MechanismsPhillip R. Zoladz, David M. DiamondOver a century of behavioral research has shown that stress can exert both positive and negative effects on memory. We have explored the idea that the complex effects of stress on learning and memory can be characterized by hormetic- and non-hormetic dose-response functions, in which stress may either stimulate or impair brain memory mechanisms, depending, in part, on the timing … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 8,188 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Prm Antibody as an Autoantibody in Dengue Virus InfectionKao-Jean Huang, Yu-Tien Cheng, Yee-Shin Lin et al.We have reported that anti-prM antibody is an enhancing antibody that enhances DV infection of non-Fc receptor bearing cells by dual specificity. We identified the epitope recognized by this anti-prM antibody, M3, which is located at the a.a.53-67of the prM protein nearby the prM/M cleavage junction and these anti-M3 antibodies could be detected in dengue patients sera. Surprisingly, this anti-prM … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,308 accessesView PDFCite
Research ArticleOpen accessIn the abstractSubacute Toxicity of Crocus Sativus L. (Saffron) Stigma Ethanolic Extract in RatsDaryoush Mohajeri, Ghafour Mousavi, Mehran Mesgari et al.The medicinal properties attributed to Crocus sativus L. (saffron) are extensive. The safety of saffron is important in relation to its medicinal applications. This study was performed to elucidate the possible toxic effects of ethanolic extract of Crocus sativus L. stigma on liver, kidney and some hematological parameters in rats. Wistar rats were randomly assigned into four groups of eight … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 4 · 31 Dec 2007 · 8,565 accessesView PDFCite
Research ArticleOpen accessIn the abstractAcute Hypotensive and Diuretic Activities of Chamaemelum nobile Aqueous Extract in Normal RatsN. A. Zeggwagh, J. B. Michel, M. EddouksThis study aims to evaluate the effect of Chamaemelum nobile (Cn) intravenous injection on cardiovascular and renal function of normal rats. Intravenous bolus injection of Cn at the dose of 50, 100 and 200 mg kg-1, produced dose dependent reduction in arterial blood pressure (p<0.001). Significant reduction in heart frequency was observed after Cn injection at a dose of 100 … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 3 · 30 Sep 2007 · 7,119 accessesView PDFCite
Research ArticleOpen accessIn the abstractCardiovascular Effect of Capparis spinosa Aqueous Extract. Part VI: in vitro Vasorelaxant EffectN. A. Zeggwagh, J. B. Michel, M. EddouksThe aim of this study was to investigate the in vitro vasorelaxanteffect of Capparis spinosa aqueous extract (CSAE) at a dose of 10 mg mL-1. Aortic rings isolated from normal wistar rats were used. The addition of CSAE during the plateau phase of contraction, induced by noradrenaline and KCl, produced a rapid relaxation. Incubation of aortic ring with CSAE during … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 3 · 30 Sep 2007 · 7,449 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Vivo Anti-malarial Tests of Nigella sativa (Black Seed) Different ExtractsH.A.A. Abdulelah, B.A.H. Zainal-AbidinNigella sativa (black seed) seeds have been used as a traditional medicine for the treatment of a variety of sicknesses including parasitic diseases. Intraperitoneal and oral administrations of ethanol, chloroform and aqueous seed extracts (50, 100, 200 and 400 µL kg-1) of N. sativa, were screened in the 4-day suppressive assays for their anti-malarial properties against Plasmodium berghei in mice. … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 8,499 accessesView PDFCite
Research ArticleOpen accessIn the abstractCPI-1189 Protects against TNBS-induced Colitis in a Rodent ModelBeverley Greenwood-Van Meerveld, Karl TylerNitrone-related therapeutics (NRTs) represents a new class of molecules that may be effective in treating inflammatory conditions. The goal of this study was to examine the effect of CPI-1189 in a rat model of inflammatory bowel disease (IBD). Colonic inflammation was induced by an enema of trinitrobenzene sulfonic acid (TNBS). Saline-enema treated rats served as controls. After 3 days colonic … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,176 accessesView PDFCite
Research ArticleOpen accessIn the abstractHydroxyapatite-induced Phagocytic Activity by Murine Macrophages in vitroV.K. Gopinath, M. Musa, A.R. Samsudin et al.The aim of the present study was to assess phagocytic activities of murine macrophages (RAW264.7 cell line) to hydroxyapatite (HA) particles. Transmission electron microscope (TEM) was used to assess localization of HA particles in the cells at 7, 15, 30 and 60 min. The HA particles and latex beads, as a control, were also incubated with the cells pretreated with … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,375 accessesView PDFCite