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72 articles for “drug development”
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Research ArticleOpen accessIn the abstractProtective Effect of Enicostemma littorale Blume on Rat Model of Diabetic NeuropathyNiraj Mukundray Bhatt, Suparna Barua, Sarita GuptaProblem statement: Poor glycemic control and oxidative stress is implicated as a common pathway in the development of diabetic neuropathy. Approach: In the present study, we investigated the protective effects of Enicostemma littorale Blume (EL) (2.5 g kg-1), a hypoglycemic and antioxidant herbal medicine in alloxan-induced diabetic neuropathy in male Charles foster rats. Results: Tail flick latency in hot immersion … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,841 accessesView PDFCite
Research ArticleOpen accessIn the abstractZonisamide: The Arizona ExperienceK.J. Oommen, Enriqe LabadieZonisamide (ZNS) is a new antiepileptic drug initially introduced in Europe, Japan and the United States (US) in the late 1980’s and was the first such drug to be clinically tested in the US, since the marketing of valproic acid in 1978. Reports of nephrolithiasis by European and US investigators resulted in the trials being terminated in the US during … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,166 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Feasibility Study of Challenges and Opportunities in Computational Biology: A Malaysian PerspectiveR. J.A. Richard, N. SriraamThe term computational biology refers to the knowledge derived from a computer analysis of biological data that includes identification of genes in DNA sequence of different organisms, prediction of structural and functional mechanism of proteins, feature extraction and classification of genomics and proteomics. Computational biology is a rapidly developing branch of science and is highly interdisciplinary, using techniques and Concepts … …American Journal of Applied Sciences, Vol. 2, Issue 9 · 30 Sep 2005 · 6,931 accessesView PDFCite
Research ArticleOpen accessIn the abstractEssential Proteins Discovery Methods based on the Protein-Protein Interaction NetworksLingZhi Zhu, Junling Zhang, Lingya He et al.Essential proteins are closely related to biological survival or reproduction and have important application value in respect of the location of disease genes, disease diagnosis and treatment, drug design. In order to discovery essential proteins, the researchers have proposed experimental approaches, but these methods require laborious and time consuming. With the development of high-throughput sequencing techniques, plenty of computational methods … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 4 · 1 Jan 2018 · 8,893 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Role of Molam in Solving Social ProblemsSitthisak ChampadaengProblem statement: Mo-lam is the most popular Isan Local Song. Its rhythm and message influenced people’s feeling and thought. The objectives of this research were to study: (1) the moving force in using the media of Mo-lam for solving social problem, (2) the role of Mo-lam and social problem solving and (3) the effect of campaign with the sharing in … …Journal of Social Sciences, Vol. 6, Issue 3 · 30 Sep 2010 · 7,979 accessesView PDFCite
Review ArticleOpen accessIn the abstractMedical Service of RobotsRelly Victoria Virgil PetrescuToday, robots have not only penetrated to create microchips in electronics but also in medicine, where it helps to perform difficult operations, especially where precision is needed and the size is small and any human error could be fatal to the patient. Robots assist the doctor in heart, brain, kidney operations, not to mention bone implants and repair of damaged … …Journal of Mechatronics and Robotics, Vol. 3, Issue 1 · 24 Apr 2019 · 7,549 accessesView PDFCite
Research ArticleOpen accessIn the abstractFuture Medicine Services RoboticsRelly Victoria V. Petrescu, Raffaella Aversa, Antonio Apicella, Florian Ion T. PetrescuIt is an entry technique in use recently, albeit in selected centers and represents a further step in the field of minimally invasive surgery. Basically it has the same indications but, at present, is reserved for selected patients. Compared to traditional video-assisted surgery presents some important differences. The surgeon is physically distant from the operative field and sits at a … …American Journal of Engineering and Applied Sciences, Vol. 9, Issue 4 · 26 Nov 2016 · 8,893 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtective Effect of Enicostemma littorale Blume Methanolic Extract on Gentamicin-Induced Nephrotoxicity in RatsNiraj Mukundray Bhatt, Kinjal Chauhan, Sharad Gupta et al.Problem statement: The Amino glycoside antibiotics cause drug induced nephrotoxicity at therapeutic doses and thus limits the use clinically. Oxidative stress is one of the main reasons for the development of nephrotoxicity. Approach: In light of this the aim of the present study was to investigate the role of mitochondrial as well as post-mitochondrial oxidative stress in the development of … …American Journal of Infectious Diseases, Vol. 7, Issue 4 · 30 Nov 2011 · 9,552 accessesView PDFCite
Research ArticleOpen accessIn the abstractInfluence of The Extract of Brown Seaweed (Turbinaria decurrens Bory) on the Histology of Colon on AOM-DSS Mouse ModelAnton Bahtiar, Dian AnggraeniUtilization of seaweed as a commodity trading or as a raw materials industry is still relatively small compared with the diversity of seaweed species in Indonesia. Turbinaria decurrens Bory is one of the brown seaweed species that has a high enough fucoxanthin content compared with other brown seaweed species. Fucoxanthin is one of the carotenoid pigments that have long been … …OnLine Journal of Biological Sciences, Vol. 17, Issue 4 · 13 Dec 2017 · 7,036 accessesView PDFCite
Review ArticleOpen accessIn the abstractSelected Genotoxic Impurities Profiling During WFI Qualification to Control Carcinogenesis in Large Volume ParenteralsMohabbat UllahWater For Injections (WFI) which is the main vehicle of Large Volume Parenterals (LVPs) should be free from trace amount of genotoxic impurities. This review gives emphasis on quantification of genotoxic trace metals during qualification of WFI in LVPs manufacturing unit. According to ICH guidelines, impurities related to drug substances are classified into three main categories: Organic impurities, inorganic (elemental) … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 1 · 27 May 2015 · 7,710 accessesView PDFCite