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Research ArticleOpen accessEvery word in the titleDrug-Protein Interactions for Clinical Research by Nucleic Acid Programmable Protein Arrays-Quartz Crystal Microbalance with Dissipation Factor Monitoring Nanoconductometric AssayClaudio Nicolini, Rosanna Spera, Nicola Luigi Bragazzi, Eugenia PechkovaConductometric monitoring of drug-gene and drug-protein interactions is of fundamental importance in the field of molecular pharmacology. Here, we present our main findings and characterizations of an important antiblastic used in neuro-oncology (Temozolomide), interacting with selected proteins that represent predictive biomarkers of the rate survival of the patients, of the outcome of chemotherapy and resistance to drug itself (namely, BRIP1 … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 17 Nov 2014 · 8,506 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDocking and Molecular Dynamics Simulations in Potential Drugs Discovery: An Application to Influenza Virus M2 ProteinMarine E. Bozdaganyan, Philipp S. Orekhov, Nicola L. Bragazzi et al.Molecular docking is a common method for searching new potential drugs. Improvement of the results of docking can be achieved by different ways-one of them is molecular dynamics simulations of protein-ligand complexes. As a model for our research we chose M2 membrane protein from influenza virus. M2 protein is a high selective tetrameric pH-gated proton channel. It was previously shown … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 11 Nov 2014 · 8,669 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCONTRIBUTION TO THE GENETIC DETERMINISM OF THE SHEEP’S MILK QUALITY. RACE INFLUENCE (HAMRA AND OULED DJELLAL) ON PHYSICO-CHEMICAL PARAMETERS AND PROTEIN PROFILEA. Ameur Ameur, F. Chougrani, A. Cheriguene et al.In order to study the race effect on the physico-chemical characteristics and protein profile, two sheep or ovine breeds Hamra and Ouled Djellal were raised in the same condition sat the ITELV (National institute of breeding) (Ain Hajar-Saida, Algeria). The analyses were focused on the pH, density, freezing, fat, total protein, dry defatted extract and total dry extract. The results … …OnLine Journal of Biological Sciences, Vol. 14, Issue 2 · 18 Jun 2014 · 6,977 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleA COMPARATIVE STUDY FOR RHODOPSIN PROTEIN FOLDING PROBLEMIman Ahmed Mahmoud, Amr Ahmed Badr, Mostafa Abdel AzimProteins are very important components in any living cells. A number of diseases such as Retinitis pigmentosa, Stargadt-like macular degeneration and Doyne Honeycomb Retinal Dystrophy (DHRD) diseases are shown to result from misfunctioning of proteins. Protein folding problem is a way to predict the best and optimal 3D molecular structure (tertiary structure) of a protein which is then considered to … …Journal of Computer Science, Vol. 10, Issue 10 · 6 May 2014 · 7,071 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleElectrophoretic Analysis of Protein Patterns in Date Palm &#34Khalas&#34 Cultivar Leaflets Among Different Locations of Al-AhsaAl-Issa Adil MohammadProteins extracted from different date palm (Phoenix dactylifera L.) trees &#34Khalas&#34 Cultivar leaflets, which were collected from 10 different locations of Al-Ahsa oasis in the eastern province of Saudi Arabia, have been analyzed by SDS-PAGE electrophoresis. The present study showed different protein patterns, which revealed by NJ and UPGMA clustering methods into three major clusters 1, 2 and 3. Cluster … …American Journal of Agricultural and Biological Sciences, Vol. 8, Issue 4 · 7 Nov 2013 · 7,280 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleBiochemical and Hematological Alterations in Mice Inoculated with Outer Membrane Protein, Lipopolysaccharides and Whole Cells of Pasteurella multocida Type B: 2Faez Firdaus Jesse Abdullah, Lawan Adamu, Abdinasir Yusuf Osman et al.Haemorrhagic septicaemia in cattle and buffaloes is an economically important livestock disease in Asia including Malaysia. Therefore, the aim of this study was to investigate the biochemical and hematological alterations in mice model inoculated with outer membrane protein, lipopolysaccharides and whole cells of Pasteurella multocida type B: 2. Two hundred healthy male mice of eight to ten weeks old were … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 3 · 17 Sep 2013 · 7,316 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEmerging Trends in Designing Short and Efficient Protein Purification ProtocolsSaurabh Gautam, Joyeeta Mukherjee, Ipsita Roy, Munishwar Nath GuptaProtein purification is carried out in both academic and industrial sectors. Both non-chromatographic approaches (precipitation, crystallization, partitioning) and chromatographic methods are used. When recombinant proteins are over expressed in foreign hosts, inclusion bodies are obtained. Many purification methods can be used to refold proteins. Many strategies allow one to avoid formation of inclusion bodies. The concept of affinity based separation … …American Journal of Biochemistry and Biotechnology, Vol. 8, Issue 4 · 25 Dec 2012 · 9,007 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDIFFERENT APPROACHES TO CRYSTALLIZATION OF MEMBRANE PROTEINSPrakash G. Doiphode, Vivek Pratap SinghCrystallography is more like an art than science. Crystallizing membrane proteins are a big challenge; membrane proteins are present in the cell membrane and serve as cell support. The most important feature of membrane protein is that it contains both hydrophobic and hydrophilic regions on its surface. They are generally much more difficult to study than soluble proteins. The problem … …OnLine Journal of Biological Sciences, Vol. 12, Issue 3 · 18 Dec 2012 · 7,288 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRole of Galphaq Containing Protein in Immune RegulationYuan Liu, Lu Gan, Guixiu ShiG proteins, one of the most important transmembrane signal transducers, contain four subfamilies. Gαq is the α subunit of Gq protein subfamily. The Gαq containing protein initially attracted attention for its physiological significance is in cardiovascular system. In recent years, its role in immune regulation has been indicated. Studies domenstrated that Gαq plays crucial role in regulating both innate and … …American Journal of Immunology, Vol. 8, Issue 4 · 18 Oct 2012 · 7,417 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRegulation of Retinol Binding Protein 4 Expression and its Relation to Adipogenesis in Bovine AdipocytesMabrouk Ragab EL-Sabagh, Abd Eldaim Mabrouk AttiaAdipogenesis is of great importance in beef cattle. Recent findings indicate that glucose, a substrate for fatty acid biosynthesis and retinoic acid enhance adipogenesis in bovine intramuscular adipocytes. However, other recent findings indicate that Retinol-Binding Protein 4 (RBP4) interferes with glucose uptake and utilization by rodents’ adipocytes. In this study we examined the regulation of RBP4 expression and its relation … …American Journal of Biochemistry and Biotechnology, Vol. 8, Issue 3 · 20 Sep 2012 · 8,399 accessesView PDFCite