Role of Galphaq Containing Protein in Immune Regulation

G proteins, one of the most important transmembrane signal transducers, contain four subfamilies. G_αq is the α subunit of G_q protein subfamily. The G_αq containing protein initially attracted attention for its physiological significance is in cardiovascular system. In recent years, its role in immune regulation has been indicated. Studies domenstrated that G_αq plays crucial role in regulating both innate and adaptive immune cells function and it is involved in the development of autoimmune disease. In this review, we summarized recent data in the role of G_αq containing protein in regulating immune cells function and the possible mechanisms.