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Research ArticleOpen accessIn the abstractA Metaheuristic-Optimized Feature Selection for Early-Stage Diabetes Prediction With SHAP-Guided Insight into Influential AttributesEsmay Azam Rochy, Jannatul Ferdaus, Uzzal Biswas et al.Diabetes is a metabolic disorder that causes elevated blood glucose. This long-term health condition can lead to cardiovascular diseases, stroke, kidney failure, visual impairment, neuropathy, and even death in critical cases. So, a Computer-Aided Diagnostic (CAD) system is necessary to diagnose diabetes automatically. A clinician can utilize a machine learning-based CAD system that automatically diagnoses many people. This paper will … …Journal of Computer Science, Vol. 22, Issue 2 · 24 Feb 2026 · 1,736 accessesView PDFCite
Literature ReviewOpen accessIn the abstractCorrelation of Atherosclerosis and Osteoarthritis, the Role of Inflammation in the Pathogenesis of Osteoarthritis and AtherosclerosisAnastasia V. Poznyak, Nikolay A. Orekhov, Aleksandra Sergeevna Utkina et al.Cardiovascular Diseases (CVD) rank among the leading causes of death globally, accounting for a substantial proportion of mortality rates and affecting millions of individuals. Risk factors such as ageing, obesity, diabetes and a sedentary lifestyle contribute significantly to the prevalence of CVD. Osteoarthritis (OA), on the other hand, is one of the most common joint disorders, affecting a large segment … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 15 Feb 2026 · 1,769 accessesView PDFCite
Case ReportOpen accessIn the abstractSurvival Following Severe Paraquat Poisoning a Case Study from the Andaman and Nicobar IslandsShiv Shankar Singh, Colin Sanchez, Prasan Kumar PandaParaquat poisoning continues to pose a significant public health challenge in the Andaman and Nicobar Islands, largely due to its alarmingly high mortality rate. In this report, we present the case of a 39-year-old male farmer who ingested 30 mL of paraquat with the intent of suicide. Initially, the patient underwent prompt gastric lavage and exhibited relative stability. Upon admission, … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 22 Jan 2025 · 10,605 accessesView PDFCite
Research ArticleOpen accessIn the abstractKenyan Sign Language Translation Using SSD MobileNet-v2 FPNlite ModelHenry Muchiri Muriithi, Geoffrey Kasembeli WanjalaSpeech impairment is a disability that impacts an individual's ability to communicate effectively through speech and hearing. Those affected often rely on alternative forms of communication, such as sign language. While sign language has become increasingly widespread in recent years, a significant challenge persists for non-sign language users, particularly in Kenya, where effective communication with sign language users remains a … …Journal of Computer Science, Vol. 21, Issue 1 · 24 Dec 2024 · 5,599 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDFCite
Review ArticleOpen accessIn the abstractCardiolipin in Pathology: Implications in AtherosclerosisAnastasia Vladimirovna Poznyak, Vasily Nikolaevich Sukhorukov, Anton Yuvenalievich Postnov et al.Mitochondria are cell organelles whose main role is to generate the energy needed for cell biochemical reactions via oxidative phosphorylation. Cardiolipin is a phospholipid that is present in the inner mitochondrial membrane and other energy-transducing membranes. Mitochondrial structure largely depends on cardiolipin, as it is involved in the biogenesis of mitochondrial cristae, folds in the inner mitochondrial membrane designed to … …OnLine Journal of Biological Sciences, Vol. 23, Issue 4 · 23 Sep 2023 · 4,792 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Electronic Cigarette E-Liquids on the Adhesion and Growth of Osteoblast CellsAna Carla Lorenz-Vieira, Cesar Augusto Magalhães Benfatti, Mahmoud RouabhiaElectronic cigarettes (E-cigarettes) were designed to replace traditional cigarettes to decrease the harmful effects of smoking. The liquid in e-cigarettes contains different chemicals, such as Propylene Glycol (PG) and Vegetable Glycerin (VG), and may contain nicotine. To be more attractive, e-liquids are supplemented with flavorings. Because vaped e-liquids are shown to be damaging to oral tissues, similar effects could occur … …OnLine Journal of Biological Sciences, Vol. 23, Issue 3 · 29 Apr 2023 · 5,155 accessesView PDFCite
Research ArticleOpen accessIn the abstractDiabetic Retinopathy Detection using Deep Learning TechniquesAswin Shriram Thiagarajan, Jithendran Adikesavan, Santhi Balachandran, Brindha Ganapathyagraharam RamamoorthyDiabetic Retinopathy is a type of eye condition induced by diabetes, which damages the blood vessels in the retinal region and the area covered with lesions of varying magnitude determines the severity of the disease. It is one of the most leading causes of blindness amongst the employed community. A variety of factors are observed to play a role in … …Journal of Computer Science, Vol. 16, Issue 3 · 13 Mar 2020 · 10,272 accessesView PDFCite
Review ArticleOpen accessIn the abstractDrug Interactions Pharmacology: A Narrative ReviewLívia Maria Barbosa Neves, Louryanne de Castro Silva, Mônica Thalia Brito de Melo et al.Thesimultaneous prescription of multiple drugs used in therapeutic schemes canresult in drug interactions, with desirable or undesirable effects. Thus, theobjective of this study was to describe the mechanisms involved in clinicallyrelevant drug interactions. This is a narrative review in which studiespublished in PUBMED and the VHL were searched in the following databases:MedLine, Lilacs, and Scielo. The search was performed in … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 25 Oct 2022 · 9,157 accessesView PDFCite
EditorialOpen accessIn the abstractImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,158 accessesView PDFCite