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51 results for “Molecular Interactions”
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EditorialOpen accessIn the abstractEditorial Commentary: Challenge of Non–AIDS-Defining Cancers (NADCs), Focusing on Trans Activation Response Element (TAR) RNA Embedding ExosomesLechuang Chen, Ge JinGlobally, 37.9 million people were living with HIV at the end of 2018 (Organization, 2018). Cancer is a major cause of mortality and morbidity in AIDS patients and chronically HIV-infected people. With the aid of combination Antiretroviral Therapy (ART), people living with HIV (PLWH) have a longer life span. However, because the virus is not completely eradicated, PLWH under antiretroviral … …American Journal of Immunology, Vol. 15, Issue 1 · 28 Nov 2019 · 6,657 accessesView PDFCite
Research ArticleOpen accessIn the abstractStatistical Improvement of Batch Culture with Immobilized Pichia pastoris Cells for rPOXA 1B Laccase ProductionMichelle Gouzy-Olmos, Luis M. Cháves-Tequia, María F. Rojas-Fajardo et al.Immobilized Pichia pastoris X33/pGAPZαA-LaccPost-Stop in Ca2+ alginate beads was employed for Pleurotus ostreatus rPOXA 1B laccase batch production. Sequential statistical improvement was achieved through Plackett-Burman (PBED), (PBED-T11, 29.5±0.8 UL-1), which allowed to increase activity by 2.36-fold (12.5±2.6 UL-1) obtained in a preliminary study. Following, Box-Behnken Experimental Design (BBED) was implemented and obtained enzymatic activity in PBED-T11 was further increased by … …American Journal of Biochemistry and Biotechnology, Vol. 14, Issue 2 · 26 Apr 2018 · 11,776 accessesView PDFCite
EditorialOpen accessIn the abstractFocalize the Structure of Myd88 in TLR Signaling Pathway to Modulate Innate Immune Response: New Target for Old DiseasesShuai Xing, Ping ZhouAll diseases have their Achilles’ Heel to target and this is especially true for immunorelated diseases which must be treated by targeting the immune system somewhere and somehow correctly. In the most recent decade, immunologists recognized that the Toll-Like Receptor (TLR) signaling pathway in innate immune system plays a double-edged role in the pathogenesis of many notorious diseases. Although the … …American Journal of Immunology, Vol. 13, Issue 3 · 6 Sep 2017 · 7,862 accessesView PDFCite
EditorialOpen accessIn the abstractIs Rerum® the New Coley's Vaccine?Marco RuggieroColey's Vaccine and Cancer Immunotherapy Dr. William B. Coley is credited for having been the first to translate the observation of an association between bacterial infections, high fever and cancer remission into a successful cancer treatment. However, it is worth noting that such an association dates back to at least one century before Coley's times; as Wiemann and Starnes from … …American Journal of Immunology, Vol. 13, Issue 2 · 31 May 2017 · 12,281 accessesView PDFCite
EditorialOpen accessIn the abstractThe Timeless Contribution of Rootstocks towards Successful Horticultural Farming: From Ancient Times to the Climate Change EraIoannis E. PapadakisGrafting is a horticultural practice by which living vegetative plant organs (root, stem and/or buds) of either the same genotype or, usually, different genotypes belonging to the same species, genus, subfamily and/or family, are tightly connected to each other to form a double-compound plant. In fact, it is a method of asexual (clonal-vegetative) propagation of plants. The basal part of … …American Journal of Agricultural and Biological Sciences, Vol. 11, Issue 4 · 16 Dec 2016 · 9,521 accessesView PDFCite
EditorialOpen accessIn the abstractProtecting crop species from biotic and abiotic constraints in the era of Global Change: are we ready for this challenge?Marco Landi, Giovanni BenelliReliable and affordable supply of food is of crucial importance to the progress and stability of human societies. During the last century, we have assisted to an extraordinary increase of crop yields, especially for the most widespread and consumed crop species, such as rice, wheat, corn and soybean. The Broadbalk experiment, one of the oldest continuous agronomic experiments in the … …American Journal of Agricultural and Biological Sciences, Vol. 11, Issue 2 · 4 Jun 2016 · 8,399 accessesView PDFCite
EditorialOpen accessIn the abstractCommentary-How do we Improve Training for Receptor Research?Marilee Ann BenoreThis issue of the American Journal of Biochemistry and Biotechnology features articles about receptor-ligand interactions that are critical to the wellbeing of all living organisms. The importance of the field of receptor research is supported by the large number of articles published in journals, the numerous specialty journals, the international conferences and the percentage of legal drugs on the market … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 4 · 8 Dec 2015 · 8,056 accessesView PDFCite
Research ArticleOpen accessIn the abstractProposal of a Genome Editing System for Genetic Resistance to Tomato Spotted Wilt VirusFederico Martinelli, Giovanni Grillone, Filippo SgroiViruses provoke considerable economical losses in agriculture. New molecular approaches to develop genetic resistance based on translational genomics and precision genetic modifications are highly expected. The type II Clustered, Regularly Interspaced Palindromic Repeats (CRISPR) system including Cas9 nuclease represent a promising and very powerful tool to specifically modulate the expression and activity of genes involved in biotic stress responses. In … …American Journal of Applied Sciences, Vol. 11, Issue 11 · 7 Jan 2015 · 7,685 accessesView PDFCite
Research ArticleOpen accessIn the abstractDrug-Protein Interactions for Clinical Research by Nucleic Acid Programmable Protein Arrays-Quartz Crystal Microbalance with Dissipation Factor Monitoring Nanoconductometric AssayClaudio Nicolini, Rosanna Spera, Nicola Luigi Bragazzi, Eugenia PechkovaConductometric monitoring of drug-gene and drug-protein interactions is of fundamental importance in the field of molecular pharmacology. Here, we present our main findings and characterizations of an important antiblastic used in neuro-oncology (Temozolomide), interacting with selected proteins that represent predictive biomarkers of the rate survival of the patients, of the outcome of chemotherapy and resistance to drug itself (namely, BRIP1 … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 17 Nov 2014 · 8,506 accessesView PDFCite