EditorialOpen accessIn the abstractIs Rerum® the New Coley's Vaccine?Marco RuggieroColey's Vaccine and Cancer Immunotherapy Dr. William B. Coley is credited for having been the first to translate the observation of an association between bacterial infections, high fever and cancer remission into a successful cancer treatment. However, it is worth noting that such an association dates back to at least one century before Coley's times; as Wiemann and Starnes from … …American Journal of Immunology, Vol. 13, Issue 2 · 31 May 2017 · 12,281 accessesView PDFCite
Research ArticleOpen accessIn the abstractFrom Hyperthermia to Immunomodulating PolysaccharidesNovak Miroslav, Vetvicka VaclavNatural polysaccharides remain overlooked as part of naturally occurring bioactive molecules. The current knowledge results in numerous clinical trials, from first observations of their effects on various diseases to precise chemical characterization and decades of biological evaluation. The aim of this report is to summarize historical perspective of the route from the first anecdotical observation to the current position, with … …American Journal of Immunology, Vol. 13, Issue 1 · 30 Mar 2017 · 7,079 accessesView PDFCite
Review ArticleOpen accessIn the abstractAbout Homeopathy or ≪Similia Similibus Curentur≫Raffaella Aversa, Relly Victoria V. Petrescu, Antonio Apicella, Florian Ion T. PetrescuHomeopathy or homoeopathy (from the Greek όμοιος/homoios, "similar" and πάθος/pathos, "suffering" or "disease") is a science created by Samuel Hahnemann in 1796. The homeopathic practice rests on three principles: The similarity, the individualization of cases and the infinitesimal. The use of the infinitesimal was proposed by Hahnemann in the early nineteenth century with the publication of "Organon der Heilkunst" (Organon … …American Journal of Engineering and Applied Sciences, Vol. 9, Issue 4 · 16 Dec 2016 · 11,553 accessesView PDFCite
EditorialOpen accessIn the abstractWhere the Future is Being Made TodayMark A. Brown, Joachim Storsberg, Christian SchmidtGrowing up, I was fascinated by The Muppet Show and the adventures of Dr. Bunsen Honeydew and his assistant Beaker. Apparently, my feelings were not unique because Muppet characters are used to ease tensions associated with education about clinical interventions (Ramsay, 2014; Rohn, 2007). Yet the opening phrase 'Where the future is being made today' has, in my opinion, summed … …American Journal of Immunology, Vol. 12, Issue 2 · 28 Jun 2016 · 7,425 accessesView PDFCite
Literature ReviewOpen accessIn the abstractThe Practical Consideration of Poliovirus as an Oncolytic VirotherapyElizabeth Denniston, Hannah Crewdson, Nicole Rucinsky et al.The inauguration of novel treatment strategies into the clinical setting faces a number of hurdles. In addition to treatment efficacy and safety, acceptance by doctors and patients is paramount to the success of novel therapies. Although viruses are the cause of numerous infectious diseases, these acellular entities have been harnessed over the years to benefit mankind. Recently, a recombinant Poliovirus-Rhinovirus … …Current Research in Virology, Vol. 5, Issue 1 · 3 Mar 2016 · 27,150 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntimicrobial Activities of Unconventional Compounds against Some Bacteria Associated with Skin Infections in Humans, Sheep and GoatsIman Shabana, Amira El-AdlyBacterial skin infections are a common problem encountered in clinical practice and causing great economic losses for sheep and goats producers. Increasing multidrug resistance of pathogens paves the way for reconsidering alternative medicine. The present study was carried out to explore the antibacterial activities of different volumes; 5, 25, 50 and 100 µL of gold nanoparticles (NPS) and the aqueous … …American Journal of Applied Sciences, Vol. 13, Issue 1 · 11 Jan 2016 · 8,021 accessesView PDFCite
Research ArticleOpen accessIn the abstractTrial Design and Analysis with Incomplete Paired DataMark Chang, Jing WangFor a clinical trial design with paired data, it often involves missing observations. In such a case, the data from the trial become a mixture of paired and unpaired data. A commonly used approach for the analysis of the trial data is to ignore the incomplete pairs. Such a treatment of missing data is not statistically efficient. We propose a … …Current Research in Biostatistics, Vol. 5, Issue 2 · 12 Nov 2015 · 7,889 accessesView PDFCite
Review ArticleOpen accessIn the abstractScope and Perspectives of New TB Drugs and VaccinesJaishree Meena, Laxman S. MeenaTuberculosis remains a major threatening infectious disease claiming millions of lives every year; hence increasing the global burden of TB disease. Co-infection with human immuno-deficiency virus and emergence of multi-drug resistant tuberculosis, extremely drug resistant tuberculosis and totally drug resistant tuberculosis enhances deadly effect of tuberculosis. To eliminate TB disease from human population several partnerships are working together like Stop … …American Journal of Infectious Diseases, Vol. 11, Issue 3 · 10 Sep 2015 · 7,943 accessesView PDFCite
Research ArticleOpen accessIn the abstractAdaptive Superiority and Noninferiority Trial Design with Paired Binary DataMark Chang, Jing WangNon-inferiority of a diagnostic test to the standard is a common issue in medical research. For instance, we may be interested in determining if a new diagnostic test is noninferior to the standard reference test because the new test might be inexpensive to the extent that some small inferior margin in sensitivity or specificity may be acceptable. Noninferiority trials are … …Current Research in Biostatistics, Vol. 5, Issue 2 · 7 Sep 2015 · 8,236 accessesView PDFCite
EditorialOpen accessIn the abstractImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,158 accessesView PDFCite