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82 articles for “Clinical Trial”
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Literature ReviewOpen accessIn the abstractDevelopment of Azithromycin Resistance in Streptococcus pneumoniae in the Setting of Trachoma Mass Drug Administration: A Systematic ReviewNazia Khan, Barbara Lachana Onen, Robin Hilder, Robin BaileyTrachoma is a blinding eye disease caused by the bacterium Chlamydia trachomatis. The current global elimination of trachoma initiative includes the use of mass drug distribution of azithromycin in areas where the prevalence of follicular trachoma is >10% in children aged 1-9 years. This study aims to investigate the high quality evidence of whether mass drug administration for trachoma causes … …American Journal of Infectious Diseases, Vol. 16, Issue 3 · 24 Jul 2020 · 7,596 accessesView PDFCite
Research ArticleOpen accessIn the abstractGenetic Diversity in Merozoite Surface Protein.1 of Plasmodium falciparum in Highlands: Wamena Papua IndonesiaRosye Hefmi Rechnelty Tanjung, Yulius Sarungu, Meidy Johana Imbiri et al.Malaria is the first killer as well as endemic disease in highland, lowland and coastal areas of Papua. In 2016 there were 160 thousands cases noted and 80% of the cases were caused by Plasmodium falciparum. Total sample for this study were provided by a clinical trial conducted from May to June 2018 in the regional hospital of Puncak Jaya, … …American Journal of Infectious Diseases, Vol. 14, Issue 4 · 11 Jan 2019 · 7,753 accessesView PDFCite
Research ArticleOpen accessIn the abstractHigh-Dose Vitamin D3 Intake Is Associated with Decreased Symptoms of Multiple SclerosisMichelle L. Steinwart, David M. DuriancikMultiple sclerosis (MS) is one of the most widespread disabling autoimmune neurological conditions of adults between the ages of 20 and 40 globally. Medical researchers do not completely understand the possible causes of MS, nor have they determined the rate of progression. A limited number of clinical trials conducted in recent years have explored the link between vitamin D deficiency … …American Journal of Immunology, Vol. 14, Issue 1 · 4 Sep 2018 · 9,283 accessesView PDFCite
Review ArticleOpen accessIn the abstractTrazodone: A Review of Its Pharmacological Properties and Its Off-Label Use in Dogs and CatsBunna Chea, Mario GiorgiTrazodone is approved by the Food and Drug Administration (FDA) for the treatment of depression and anxiety in humans, it can perform these functions due to its selective serotonin receptor antagonism and reuptake inhibition properties. Trazodone has not been approved for animals by the FDA but it is legally prescribed by veterinarians as an off-label drug for dogs and cats. … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 4 · 31 Oct 2017 · 10,858 accessesView PDFCite
EditorialOpen accessIn the abstractIs Rerum® the New Coley's Vaccine?Marco RuggieroColey's Vaccine and Cancer Immunotherapy Dr. William B. Coley is credited for having been the first to translate the observation of an association between bacterial infections, high fever and cancer remission into a successful cancer treatment. However, it is worth noting that such an association dates back to at least one century before Coley's times; as Wiemann and Starnes from … …American Journal of Immunology, Vol. 13, Issue 2 · 31 May 2017 · 12,281 accessesView PDFCite
Review ArticleOpen accessIn the abstractCOVID 19-How is the Exposure of the Pediatric Population? A Systematic Review ProtocolVitória Monteiro Monte Oliveira, Paulo Francisco de Almeida-Neto, Francisca Dalila Paiva Damasceno de Lima et al.Solid information on exposure and how to treat COVID-19 in pediatric patients is not yet conclusive in the literature, because of this it is necessary to make a critical analysis of the available data in order to provide common points on the theme in question. This systematic review protocol is registered in PROSPERO (ID: CRD42020181835) and aims through searches in … …American Journal of Infectious Diseases, Vol. 17, Issue 2 · 12 Apr 2021 · 6,868 accessesView PDFCite
EditorialOpen accessIn the abstractWhere the Future is Being Made TodayMark A. Brown, Joachim Storsberg, Christian SchmidtGrowing up, I was fascinated by The Muppet Show and the adventures of Dr. Bunsen Honeydew and his assistant Beaker. Apparently, my feelings were not unique because Muppet characters are used to ease tensions associated with education about clinical interventions (Ramsay, 2014; Rohn, 2007). Yet the opening phrase 'Where the future is being made today' has, in my opinion, summed … …American Journal of Immunology, Vol. 12, Issue 2 · 28 Jun 2016 · 7,425 accessesView PDFCite
Research ArticleOpen accessIn the abstractTrial Design and Analysis with Incomplete Paired DataMark Chang, Jing WangFor a clinical trial design with paired data, it often involves missing observations. In such a case, the data from the trial become a mixture of paired and unpaired data. A commonly used approach for the analysis of the trial data is to ignore the incomplete pairs. Such a treatment of missing data is not statistically efficient. We propose a … …Current Research in Biostatistics, Vol. 5, Issue 2 · 12 Nov 2015 · 7,889 accessesView PDFCite
EditorialOpen accessIn the abstractAre we Able to Harness the Immunomodulatory Power of Cytokines for Novel Autoimmune Disease Treatments?Giuseppe Nocentini, Graziella Migliorati, Carlo RiccardiSince the end of the 1970s, interleukin 2 (IL-2) has been known as a key player in T cell expansion/activation (Watson et al., 1980). In the late 1980s, some groups used IL-2 to stimulate the immune systems of tumour patients (Jacobs et al., 1986). The idea seemed brilliant and several attempts were made, but the results were disappointing (Lim et … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 22 Oct 2015 · 7,625 accessesView PDFCite
Research ArticleOpen accessIn the abstractAdaptive Superiority and Noninferiority Trial Design with Paired Binary DataMark Chang, Jing WangNon-inferiority of a diagnostic test to the standard is a common issue in medical research. For instance, we may be interested in determining if a new diagnostic test is noninferior to the standard reference test because the new test might be inexpensive to the extent that some small inferior margin in sensitivity or specificity may be acceptable. Noninferiority trials are … …Current Research in Biostatistics, Vol. 5, Issue 2 · 7 Sep 2015 · 8,236 accessesView PDFCite