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312 articles for “Agents”
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Research ArticleOpen accessEvery word in the titleP-Glycoprotein-Mediated Efflux and Drug Sequestration in Lysosomes Confer Advantages of K562 Multidrug Resistance Sublines to Survive Prolonged Exposure to Cytotoxic AgentsNathupakorn Dechsupa, Samlee MankhetkornProblem statement: Cellular drug resistance to anticancer agents is major obstacle in cancer chemotherapy and the mechanisms by which these MDR cells possess for protecting themselves to survive prolonged exposure to cytotoxic agents still debating. The study aimed to clarify the role of P-glycoprotein (Pgp) and enhanced drug sequestration in lysosomes to confer the multidrug resistance K562 cells with varied … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 7,508 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleVoltage-Gated Channels as Causative Agents for EpilepsiesMutasem Abuhamed, Xiao Bo, Kun Xia et al.Problem statement: Epilepsy is a common neurological disorder that afflicts 1-2% of the general population worldwide. It encompasses a variety of disorders with seizures. Approach: Idiopathic epilepsies were defined as a heterogeneous group of seizure disorders that show no underlying cause .Voltage-gated ion channels defect were recognized etiology of epilepsy in the central nervous system. The aim of this article … …American Journal of Immunology, Vol. 4, Issue 4 · 31 Dec 2008 · 6,962 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSensitivities of Uterine Adenocarcinoma, Mixed Mullerian Tumor (MMT) and Sarcoma Cell Lines to Chemotherapeutic Agents and a Flex-Het DrugJohnny Hyde, Doris M. BenbrookThe administration and combination of a variety of chemotherapeutic agents for treatment of advanced or recurrent uterine cancer of different histologies is under current debate. Mixed Mullerian Tumors (MMTs), which contain both adenocarcinoma and sarcoma components, are the most rate histologic type and it is therefore difficult to conduct clinical trials to determine if they should be treated like endometrial … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 7,465 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRetrieving Information from the Invisible Web Using Mobile AgentsFabien-Kenzo Sato, Samuel Pierre, Roch H. GlithoThis study proposes a model of information retrieval on the invisible Web by using the mobile agent paradigm. The developed architecture uses the power of a search engine to provide a list of sites of the invisible Web which are likely to be relevant and launches a dynamic search on these sites, thanks to mobile agents. To compare and experiment … …Journal of Computer Science, Vol. 1, Issue 2 · 30 Jun 2005 · 6,843 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleA Kit for Multiplexed Detection of Antibodies to Agents of Hemotransmissible InfectionsAlexander Poltavchenko, Anna Ersh, Pavel Filatov et al.The paper presents the results of laboratory trials of method using complex initial testing of antibodies to six agents of hemotransmissible infections: HIV, hepatitis B and C viruses, cytomegalovirus, Treponema pallidum and Toxoplasma gondii. The method is based on multiplexed dot immunoassay using plane protein arrays (immunochips) with the use of colloidal gold conjugates and silver development. We describe composition … …OnLine Journal of Biological Sciences, Vol. 16, Issue 3 · 6 Sep 2016 · 7,170 accessesView PDFCite
Research ArticleOpen accessEvery word in the titlePREVALENCE OF MASTITIS PATHOGENS AND THEIR RESISTANCE AGAINST ANTIMICROBIAL AGENTS IN AWASSI SHEEP IN AL-BALQA PROVINCE OF JORDANAzmi D. Hawari, Maher Obeidat, Saddam Sh. Awaisheh et al.The primary objective of this study was to establish data on mastitis in Awassi Sheep in Al-Balqa Province of Jordan. Milk samples were collected from 260 lactating ewes that selected randomly from eight flocks. California Mastitis Test (CMT) gave result with 220 milk samples; 122 samples (55.5%) showed positive CMT. Infection with some bacterial species was associated with positive CMT. … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 2 · 3 May 2014 · 7,503 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDesign, Synthesis, Biological Screening and Structure Activity Relationship Study of 4, 6-Dimethyl-2-(Substituted) Mercapto-3-(Substituted) Pyridines as Anti Tubercular AgentsMehul M. Patel, Mahesh T. ChhabriyaProblem statement: Tuberculosis is a leading global mortality factor which has not been effectively controlled, with 1.7 million deaths per year and 8.9 million new cases. Aerobic microbe Mycobacterium tuberculosis H37Rv (MTB) is the causative agent of tuberculosis. Although many active antitubercular agents have since been developed, drug resistance will continue to be a problem. Therefore, there is a clear … …American Journal of Infectious Diseases, Vol. 7, Issue 3 · 3 Nov 2011 · 7,432 accessesView PDFCite
Research ArticleOpen accessEvery word in the titlePrevalence and Distribution of Mastitis Pathogens and their Resistance against Antimicrobial Agents in Dairy Cows in JordanAzmi D. Hawari, Fawzi Al-DabbasThe primary objective of this study was to determine the aetiology of bovine mastitis in ten herds of Holstein Friesian cow in Jordan, the prevalence of mastitis pathogens in dairy cows and their resistance to selected antimicrobial agents. Milk samples were collected from 220 lactating cows to determine the clinical and subclinical mastitis by white side test and confirmed by … …American Journal of Animal and Veterinary Sciences, Vol. 3, Issue 1 · 31 Mar 2008 · 7,681 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleIsolation and Identification of Bacteria Leading to Microbial Spoilage of Sweet Potato and Screening for Antistaling Agents Running HeadDaoqi Liu, Huili Liu, Yuanyuan Dang et al.To develop natural preservatives tailored for sweet potatoes, the control effect of essential oils on the spoilage microorganisms of sweet potatoes is uncertain. Therefore, we first isolated and identified the dominant spoilage bacteria from spoiled sweet potatoes. Micrococcus aloeverae, Priestia aryabhattai, and Glutamicibacter arilaitensis were identified through screening, morphological observation, gram staining, and 16S rDNA assays. Subsequently, five plant essential … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 1 · 26 Apr 2024 · 5,224 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMechanism Analysis of Artemisinin and Artesunate as Lung Cancer Therapy Agents Through in Silico MethodDidik Harmoko, Vivitri Dewi Prasasty, Adi YulandiSeveral in vitro studies have focused on the ability of artemisinin and its derivatives to suppress lung cancer cells, but there are still many biological processes and mechanisms, such as the interactions between the active compounds (ligands) and receptors that are not well understood and require further research. Drug targeting for lung cancer will be more precise and the inhibition … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 15 Feb 2024 · 6,149 accessesView PDFCite