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35 results for “platelet”
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Research ArticleOpen accessIn the keywordsRelease of Endogenous Chondroitin Sulfate and Heparin as Consequence of Dysregulated Proteolysis in COVID-19Marco RuggieroInfection by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), the pathogen responsible for COVID-19, is associated with immune-mediated responses that lead to dysregulated activation of proteolytic enzymes; these contribute to damage to the endothelium, thrombosis, hypercoagulability and other hematologic complications that include thrombotic thrombocytopenia, a complication of severe COVID-19 as well as a potentially fatal adverse effect of COVID-19 vaccination. … …American Journal of Immunology, Vol. 17, Issue 1 · 29 Dec 2021 · 7,691 accessesView PDFCite
Research ArticleOpen accessIn the keywordsDiphenylhydantoin Promotes Proliferation in The Subventricular Zone and Dentate GyrusAlma Y. Galvez-Contreras, Rocio E. Gonzalez-Castaneda, Sonia Luquin et al.Problem statement: Diphenylhydantoin (phenytoin) is an antiepileptic drug that generates hyperplasia in some tissue by stimulating Epidermal Growth Factor (EGFR) and Platelet-Derived Growth Factor beta (PDGFR-β) receptors and by increasing serum levels of basic fibroblast growth factor (bFGF, FGF2 or FGF-β). Neural stem cells in the adult brain have been isolated from three regions: the Subventricular Zone (SVZ) lining the … …Neuroscience International, Vol. 3, Issue 1 · 6 Mar 2012 · 9,141 accessesView PDFCite
Research ArticleOpen accessIn the keywordsInsertion of poly (ethylene glycol)-lipid reduces the liposome-encapsulated hemoglobininduced thrombocytopenic reactionVibhudutta Awasthi, Beth Goins, William T. PhillipsInteraction with platelets has been recognized as a concern in the development of liposome-encapsulated hemoglobin as an oxygen carrier. This reaction causes a significant drop in circulating platelets in a rapid and transient fashion. We studied the effect of lipid bilayer charge on the magnitude of drop in circulating platelets. We also investigated the effect of post-inserted PEG-lipid on this … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,382 accessesView PDFCite
Research ArticleOpen accessIn the keywordsExpression, Purification and Activity Assay of Two New Recombinant Antagonists of Fibrinogen ReceptorJianbo Yang, Jia Yao, Kun Yang et al.The gene sequence of Decorsin which is extracted from a kind of North American leeches was synthesized. Two recombinant proteins, Annexin V plus Decorsin (AnnV-D39) and Annexin V plus the carboxyl terminal 27 amino acid residues of Decorsin(AnnV-D27), were constructed. And a 10 amino acids linker peptide of GGGGSGGGGS was inserted between Annexin V and Decorsin in AnnV-D39. Using pET-28(a+) … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 6,918 accessesView PDFCite
Research ArticleOpen accessIn the keywordsPassage Effect on Aging of Human Umbilical Cord Derived Mesenchymal Stem CellDian Mediana, Isabella Kurnia Liem, Jeanne Adiwinata Pawitan, Noviyanti GoeiTo be used in regenerative medicine, cells should be checked for various conditions, including cell aging. This study aimed to learn senescent profile and its relation to cell viability, proliferation and cell size in various passages, which were done in α-MEM-10% PRP medium, until senescence-associated β-galactosidase (SA-β-Gal) positive cells were found. Stem cells were isolated from umbilical cord tissue by … …OnLine Journal of Biological Sciences, Vol. 15, Issue 3 · 31 Jul 2015 · 8,041 accessesView PDFCite
Research ArticleOpen accessIn the abstractEpidemiological, Molecular, and Hematological Characteristics of Infection by Anaplasma Spp., Babesia Spp., Ehrlichia Spp., and Hepatozoon Spp., in Shelter Dogs from Northeastern ColombiaMaría Victoria Esteban-Mendoza, Ian Sebastián Murcia-Cueto et al.Tick-borne pathogens represent a significant health problem for dogs, particularly in shelters, where overcrowding and limited veterinary care can facilitate transmission. Although these agents are widely distributed throughout Colombia, epidemiological studies in shelter populations remain scarce. This study evaluated 112 dogs from nine shelters in the Metropolitan Area of Bucaramanga (MAB), Santander, to determine the frequency of infections caused by … …American Journal of Animal and Veterinary Sciences, Vol. 21, Issue 3 · 9 Oct 2026 · 589 accessesView PDFCite
Research ArticleOpen accessIn the abstractHematological and Biochemical Analysis of Asymptomatic Fascioliasis of Bali Cattle (Bos Javanicus)Maskur, Adji Santoso Drajat, Sulaiman Ngongu Depamede et al.The research was to examine the hematological characteristic of fascioliasis in Bali cattle in year-round irrigated rice fields in tropical areas. Fifty cattle raised in rice field areas were examined by hematology, coproscopy, physiology, and liver function tests. The results showed that 50 cattle had heartbeat, respiratory and rectal temperature in normal standard, but, 41 (82%) out of 50 cattle … …American Journal of Animal and Veterinary Sciences, Vol. 17, Issue 3 · 4 Aug 2022 · 6,207 accessesView PDFCite
Review ArticleOpen accessIn the abstractBioactive Functional Foods for Cardiovascular DiseasesKiren Mustafa, Iqra Ajmal, Tahira Naz et al.Cardiovascular Disease (CVD) is a chronic pathological disorder regarded as a serious health concern round the globe. It is a multifactorial disease, with a range of various causative agents, among that dietary factor is considered the most important and may to a large degree determine CVD risk. Unfortunately, it has been less widely investigated. This review outlines the general aspects … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 3 · 17 Aug 2020 · 7,842 accessesView PDFCite
Research ArticleOpen accessIn the abstractToxicological Study of Hydroalcohol Leaf Extract of Acanthospermum hispidum (Asteraceae)Diallo Aboudoulatif, Dowou Salem, Badjabaissi Essotolom et al.Acanthospermum hispidum is a widely plant used in African traditional medicine. This study aims to assess cardiotoxicity and sub-chronic (28-days) oral toxicity of hydroalcohol leaf extract of A. hispidum. The sub-chronic toxicity was evaluated after administering daily oral doses of 500 and 1000 mg/kg body wt., for 28 days to the rats, biochemical and haematological assessments as well as body … …American Journal of Pharmacology and Toxicology, Vol. 15, Issue 1 · 16 Mar 2020 · 7,757 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvolvement of the α/β Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5)Anwar M Hasan, Gordon DentEosinophils are the principal effector cells for allergic inflammation in a variety of diseases, in which they contribute to tissue damage and remodelling processes via the secretion of cytotoxic granular proteins and cytokines. The intracellular mechanisms that control the activation, recruitment and survival of eosinophils are fundamental in understanding these disease processes. Phosphoinositide 3-kinase (PI3K) has been shown previously to … …American Journal of Immunology, Vol. 13, Issue 4 · 26 Oct 2017 · 7,946 accessesView PDFCite