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Author

William T. Phillips

University of Texas Health Science Center at San Antonio, United States
1 article in our journals

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Research ArticleOpen accessInsertion of poly (ethylene glycol)-lipid reduces the liposome-encapsulated hemoglobininduced thrombocytopenic reactionVibhudutta Awasthi, Beth Goins, William T. PhillipsInteraction with platelets has been recognized as a concern in the development of liposome-encapsulated hemoglobin as an oxygen carrier. This reaction causes a significant drop in circulating platelets in a rapid and transient fashion. We studied the effect of lipid bilayer charge on the magnitude of drop in circulating platelets. We also investigated the effect of post-inserted PEG-lipid on this … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,377 accessesView PDFCite