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44 results for “mutations”
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Research ArticleOpen accessIn the abstractImpact of Integrated Nursing and Digital Droplet PCR on Bullous Dermatoid Conditions: A Randomized Controlled TrialConghui ChenBullous skin disease is an autoimmune disease characterized by the formation of blisters on the skin or mucous membrane, which seriously impairs the quality of life and overall health. Similar to the research on biomolecules (mechanics of protein interaction), cells (including cell membrane elasticity, cell adhesion, cytoskeletal dynamics, response to mechanical stimulation, cell deformation and cell endoforce transfer) and tissue … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 2 Jul 2026 · 985 accessesView PDFCite
Research ArticleOpen accessIn the abstractOrlistat Induce Renal Toxicity, DNA Damage, and Apoptosis in Normal and Obese Female RatsHaneen Mushtaq Hameed, Ahmed Flayyih Hasan, Zainab Haytham Razooki et al.Obesity has been linked to several chronic diseases, including fatty liver disease, fatty heart disease, diabetes mellitus, hypertension, obstructive sleep apnea, and cancer. The purpose of the current study was to determine how Orlistat affected renal toxicity, DNA damage, and apoptosis that were brought on by obesity in normal and obese female rats. There were four groups made up of … …OnLine Journal of Biological Sciences, Vol. 23, Issue 1 · 18 Jan 2023 · 5,831 accessesView PDFCite
Research ArticleOpen accessIn the abstractOmicron SARS Co-V2 Sub Variants BA.2 and BA.3 have Lower Free Binding Energy than BA.1Rujittika Mungmunpuntipantip, Viroj WiwanitkitCOVID-19 is currently a major global public health concern. The newest dangerous type, Omicron, comes in late 2021 and spreads quickly from Africa. There have already been new omicron subvariants discovered. Mutations inside the molecular structure of omicron subvariant induce intriguing molecular changes. The authors undertook a study to examine the effects of mutations in important COVID-19 omicron subvariants, including … …American Journal of Applied Sciences, Vol. 19, Issue 1 · 26 Sep 2022 · 6,019 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Comprehensive Review on Skin Cancer Detection Strategies using Deep Neural NetworksAkepati Sankar Reddy, Gopinath M. PSkincancer is a deadly malignancy. Incomplete D.N.A. repair in skin cells causeshereditary mutations and cancer. Early skin cancer is easier to treat since itspreads slowly to other body areas. As a result, the optimal time to find it isduring its infancy. Because of the rising frequency of skin cancer, the highmortality rate, and the high cost of medical treatment, early … …Journal of Computer Science, Vol. 18, Issue 10 · 5 Oct 2022 · 6,400 accessesView PDFCite
Research ArticleOpen accessIn the abstractMolecular-Biological Properties of the Attenuated Strain of Salmonella Abortus-Equi E-841, used in the Creation of a Vaccine against Abortion of MaresAssiya Mussayeva, Natalya Yegorova, Merey Yerishov et al.Salmonella abortion of mares takes a leading place in the in factious pathology of horses and leads to the abortion of pregnant mares and infected stallions become salmonella carriers. The disease with salmonella abortion manifests itself in the last months of pregnancy, maybe-during the mass foal of mares-in the spring. The article results obtained of studies on the biological properties … …American Journal of Animal and Veterinary Sciences, Vol. 16, Issue 2 · 28 May 2021 · 7,120 accessesView PDFCite
Research NotesOpen accessIn the abstractTime-Resolution of Climate Change Monitoring Volcanic Cycles, Stromboli, Ocean Floor Biota and Pandemics (?)Giovanni Pietro Gregori, Gabriele PaparoClimate change is an ongoing, poorly understood and disquieting challenge. The primary drivers are debated. Clear evidence is however suggestive of a time variation of the planetary release of endogenous energy. In fact, soil exhalation is an unprecedented challenge for humankind, as a phenomenon of this kind happens only every 27.40.05 Ma, while human history spans only the last 30,0000 … …American Journal of Engineering and Applied Sciences, Vol. 14, Issue 2 · 7 Sep 2021 · 6,252 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn silico Assessment of the Arg85Trp Glucokinase Mutation EffectsFaiza Bouldjennet, Souhila Bouaziz-Terrachet, Malha Azzouz, Rachida RaacheMaturity Onset Diabetes of the Young (MODY) is a heterogeneous group of autosomal dominantly inherited, young-onset β-cell disorders that account for approximately 2% of non-insulin-dependent diabetics in Europe. MODY2 or GCK-MODY is caused by inactivating heterozygous mutations in the glucokinase. Linkage of MODY to the Arg85Trp GCK mutation, among Algerian diabetic patients has been established in our previous research. The … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 27 Feb 2020 · 6,808 accessesView PDFCite
Research ArticleOpen accessIn the abstractColor Doppler Evaluation of Isovolumetric Relaxation Time and of Signals Arising from Axons of the Median Nerve as a Means to Evaluate Mitochondrial Functionality in the Context of Immunotherapy of Cancer and Chronic Conditions Associated with Mitochondrial DysfunctionStefania Pacini, Marco RuggieroReactive Oxygen Species (ROS) arising from the disruption of mitochondrial respiration act as endogenous mutagens and tumor promoters. When production of ROS exceeds the capacity of DNA repair mechanisms, random mutations and aneuploidy ensue, thousands of genes become unbalanced and genetic/epigenetic chain reactions lead to progressive aneuploidy with only two outcomes: karyotypes so altered that are not viable or karyotypes … …American Journal of Immunology, Vol. 15, Issue 1 · 12 Oct 2019 · 9,690 accessesView PDFCite
Research ArticleOpen accessIn the abstractGenetic Mutation Assessment of NPM1 Gene and Gene Expression of MDR1 in Iraqi Patients with Acute Myeloid LeukemiaAhmed Abduljabbar Suleiman, Ali Zaid Al-Saffar, Tamadher Abbas Rafaa, Hasan Abdulwahab JwadSince its discovery, mutations in NPM1 have been frequently associated with a large number of Acute Myeloid Leukemia (AML) patients. The vast majority of genetic changes were previously detected in exon 12, however little information report mutations in Nuclear Export Signal region (NES) of NPM1. Sequencing analysis included exon 2 and 3 for 75 Iraqi AML patients showed three SNPs, … …OnLine Journal of Biological Sciences, Vol. 18, Issue 1 · 11 Jan 2018 · 7,782 accessesView PDFCite
Research ArticleOpen accessIn the abstractMolecular Detection of Follicle Stimulating Hormone Receptor Polymorphisms and Luteinizing Hormone Gene Variations in Primary and Secondary Iraqi Infertile WomenNoor Basim Naser, Dr. Ezeddin Atia Albayyar, Dr. Susan Abed ZaidanThe current study aimed to determine the role of hormonal disturbances in infertility, moreover assessing variations at the molecular level that could affect this disease. The study examined 90 blood samples, 30 patients with primary infertility, 30 patients with secondary infertility and 30 healthy women as control. FSH and LH were measured using Electrochemiluminescence assay. DNA was isolated for molecular … …OnLine Journal of Biological Sciences, Vol. 18, Issue 4 · 15 Nov 2018 · 7,553 accessesView PDFCite