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36 articles for “leukemia”
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Review ArticleOpen accessEvery word in the titleThe Triple Immune Argument; Surveillance/Evasion/ Senescence and the Increased Incidence of Acute Myeloid Leukemia Observed with AgeManar M. IsmailAML originates from genetic insults of hematopoietic stem and progenitor cells (HSPCs/HSCs) that was identified earlier as leukemia stem cells (LSCs). In quiescent state, trafficking immune cells are crucial for eradication of aberrant clones and obtaining balance between proliferation and apoptosis to maintain HSCs pool. Regulatory T-cells shield the HSCs from the inflammatory reactions by suppressing T- and B- cells. … …American Journal of Immunology, Vol. 13, Issue 4 · 22 Dec 2017 · 7,806 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleLeukemia Inhibitory Factor (LIF) Gene Polymorphism and its Impact on Reproductive Traits of PigsM. A. Leonova, L. V. Getmantseva, V. N. Vasilenko et al.The purpose of this study was to determine the frequencies of alleles and genotypes of the Leukemia Inhibitory Factor (LIF) gene (ID: 399503) in Landrace, Large White and Duroc pigs in Russia and to evaluate the impact on productive traits of pigs. Polymorphism was genotyped using PCR-RFLP method. In the course of studies we observed a different distribution of allele … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 4 · 18 Oct 2015 · 7,404 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCytotoxic Activity of Tinospora crispa Crude Extracts (Stem) Against K562 Human Leukemia CellsNormah Awang, Haziratul Iffah Ruzali, Rapidah Mohamad et al.Tinospora crispa (T. crispa) is traditionally used as an herbal medicine for treatment of gout and is an analgesic, anti-inflammatory and antihyperuricemic agent. Cytotoxicity of hexane, dichloromethane, ethanol and aqueous extracts of T. crispa stem against K562 cells was assessed. Crude extracts of T. crispa stem were obtained by sonication and maceration methods. T. crispa stem powder was macerated and … …OnLine Journal of Biological Sciences, Vol. 19, Issue 2 · 11 May 2019 · 7,870 accessesView PDFCite
Research ArticleOpen accessIn the keywordsHematologic Cancer Cell Detection and Classification Using Optimized VGG-19 with Stratified K-fold Cross-ValidationHema Patel, Himal Shah, Gayatri Patel, Atul PatelThe most prevalent pediatric blood malignancy is acute lymphoblastic leukemia (ALL). ALL is a lethal disease in which patients have a lower survival rate. Its prompt detection and precise categorization are essential for successful treatment. Manual microscopic diagnosis is laborious, prone to mistakes, and heavily reliant on specialized knowledge. With stratified 7-fold cross-validation, which assures an equal ratio of normal … …Journal of Computer Science, Vol. 21, Issue 11 · 24 Dec 2025 · 1,812 accessesView PDFCite
Research ArticleOpen accessIn the keywordsChildhood Cancer-a Hospital based study using Decision Tree TechniquesK. Kalaivani, R. ShanmugalakshmiProblem statement: Cancer is generally regarded as a disease of adults. But there being a higher proportion of childhood cancer (ALL-Acute Lymphoblastic Leukemia) in India. The incidence of childhood cancer has increased over the last 25 years, but the increase is much larger in females. The aim was to increase our understanding of the determinants of south Indian parental reactions … …Journal of Computer Science, Vol. 7, Issue 12 · 17 Oct 2011 · 7,057 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCefepime Monotherapy is as Effective as Ceftriaxone Plus Amikacin in Pediatric Patients with Cancer and High-Risk Febrile Neutropenia: A Randomized ComparisonCarlos Alberto Pires Pereira, Antonio Sérgio Petrilli, Fabianne Altruda Carlesse et al.The empirical use of antibiotic therapies is widely accepted in patients with fever and neutropenia during cancer chemotherapy. The use of intravenous monotherapy with broad-spectrum antibiotics in patients with high-risk of complications is an appropriate alternative. However, few data are available in pediatric patients. We conducted a prospective, randomized, open study in patients with lymphoma or leukemia who had fever … …American Journal of Infectious Diseases, Vol. 4, Issue 4 · 31 Dec 2008 · 7,404 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAntitumor and Quantitative Structure Activity Relationship Study for Dihydropyridones Derived from CurcuminBahjat A. Saeed, Kawkab Y. Saour, Rita S. Elias et al.Problem statement: Pyridones are known to have variety of biological activities like antitumor, antibacterial, antiinflamatory and antimalarial activities. This study presented antitumor evaluation of dihydropyridones derived from curcumin, as well as curcumin for comparison. Approach: The compounds evaluated for a preliminary estimation of the in vitro tumor inhibiting activity against 11 of tumor cell lines by using Microculture Tetrazolium assay … …American Journal of Immunology, Vol. 6, Issue 1 · 31 Mar 2010 · 8,262 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Health Risk of Formaldehyde to Human BeingsS. Norliana, A. S. Abdulamir, F. Abu Bakar, A. B. SallehProblem statement: Formaldehyde was classified as a potential human carcinogen, identified by the US Environmental Protection Agency and International Agency for Research on Cancer as a Class 2A carcinogen. It also can cause irritation to human. However, formaldehyde present in biological fluids or tissues and environment as a result of natural processes or from man-made sources and can be emitted … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 15,273 accessesView PDFCite
Review ArticleOpen accessIn the abstractBioprospection of Endophytic Bacteria Isolated from Mangrove Ecosystems and their Potential Biotechnological ApplicationsAlfian Mubaraq, Mariani Sembiring et al.The unique mangrove ecosystem hosts a variety of microorganism activities, including the crucial role of endophytic bacteria. Microorganisms found in mangrove forests play an important role in maintaining the biosphere by uniting various living beings and can be vital for future biotechnological applications. The use of microorganisms in the field of biotechnology is prevalent for producing antimicrobials against pathogenic bacteria … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 16 Aug 2024 · 4,996 accessesView PDFCite
Case ReportOpen accessIn the abstractDisseminated Cryptococcal Disease with Skeletal and Pulmonary InvolvementNikko Rowe Asuncion Tabliago, Paula McKenzie, Caroline Dillon, Amelia MorganCryptococcus neoformans is an encapsulated yeast that typically causes illness in immunocompromised hosts. Manifestations of the disease include pulmonary, Central Nervous System (CNS), and rare skeletal involvement. Optimal antifungal therapy for skeletal involvement has yet to be established. Here we present a potential antifungal regimen for disseminated cryptococcal disease with skeletal and pulmonary involvement in a patient with Chronic Lymphocytic … …American Journal of Infectious Diseases, Vol. 18, Issue 3 · 1 Aug 2022 · 5,910 accessesView PDFCite