Author

Vasily Nikolaevich Sukhorukov

Institute of Experimental Cardiology, National Medical Research Center of Cardiology, Moscow, Russia

24 articles in our journals

Articles where this person is an author, newest first. People are matched by their name as printed (no ORCID iD is recorded for them), not by name alone; search the name as text to find namesakes too.

Research ArticleOpen accessMMP-9 is a Potential Prognostic Marker of Left Ventricular Remodeling in Patients with Coronary Artery DiseaseMikhail Aleksandrovich Popov, Anastasia Vladimirovna Poznyak, Dmitry Valerievich Shumakov et al.Matrix Metalloproteinase-9 (MMP-9) emerges as a promising prognostic marker for assessing left ventricular remodeling in patients with coronary artery disease, particularly in the context of Ischemic Heart Disease (IHD) complicated by left ventricular aneurysm. In this study, we conducted two parallel investigations to explore the prognostic significance of MMP-9 in patients with multivessel coronary artery disease undergoing left ventricular reconstruction … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 11 Jul 2024 · 4,310 accessesView PDF Cite

Review ArticleOpen accessOverview of Vascular Smooth Muscle Cells, Endothelial Cells, and Macrophages Apoptosis During Atherosclerosis DevelopmentAnastasia Vladimirovna Poznyak, Varvara Alexandrovna Orekhova, Vasily Nikolaevich Sukhorukov et al.Atherosclerosis is a complex disease that has garnered significant attention from researchers studying its various aspects. Its pathogenesis involves a wide array of cellular and molecular components, as well as crucial mechanisms and processes crucial for cellular and organismal functioning. Atherosclerosis is considered a chronic inflammatory disease characterized by disrupted lipid metabolism, oxidative stress, and immune response. Apoptosis, a fundamental … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 5 Jul 2024 · 4,675 accessesView PDF Cite

Review ArticleOpen accessSIRT1 Controls Lipid Metabolism Under Physiological and Pathological Conditions: Implications in AtherosclerosisAnastasia Vladimirovna Poznyak, Ludmila Viktorovna Nedosugova, Victoria Alexandrovna Khotina et al.This comprehensive review examines the multifaceted role of Sirtuin 1 (SIRT1) in cellular metabolism and energy regulation, with a particular focus on its involvement in lipid metabolism and glucose regulation. Additionally, SIRT1's impact on several pathologies, including osteoarthritis, diabetes, and cardiovascular disease, is explored. Notably, this review sheds light on the unique contribution of SIRT1 in the development and progression … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 7 Jun 2024 · 4,739 accessesView PDF Cite

Literature ReviewOpen accessAtherosclerosis and Alzheimer’s Disease Interconnection: Inflammation, Aβ and MoreAnastasia Vladimirovna Poznyak, Victoria Khotina, Roghayyeh Vakili-Ghartavol et al.Despite being the leading cause of CVD and cardiovascular mortality globally, Atherosclerosis (ATH) remains underdiagnosed and undertreated. The reasons behind Alzheimer’s Disease (AD) also remain unclear and there is currently no cure for it. At present, at least 55 million people are believed to be suffering from the disorder and the figures are expected to grow. At the same time, … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 26 May 2024 · 4,761 accessesView PDF Cite

Literature ReviewOpen accessAtherosclerosis as Age-Related Disease: The Potential of Sirtuins TreatmentAnastasia Vladimirovna Poznyak, Victor Yurievich Glanz, Vasily Nikolaevich Sukhorukov et al.Atherosclerosis, a global health concern, has attracted researchers worldwide due to its severe consequences. The elderly are particularly susceptible to cardiovascular diseases and events, making them a high-risk group. Although gaps in our understanding of atherosclerosis pathogenesis persist, it is evident that oxidative stress, endothelial dysfunction, inflammation, mitochondrial dysfunction, and autophagy impairments are key components of its development. Remarkably, these … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 16 May 2024 · 4,717 accessesView PDF Cite

Review ArticleOpen accessOverview of Atherosclerotic Plaque: From Formation to ComplicationAnastasia Vladimirovna Poznyak, Varvara Alexandrovna Orekhova, Vasily Nikolaevich Sukhorukov et al.Atherosclerosis is a serious worldwide health problem. The pathogenesis of this disease is complex and includes a multilevel interaction of such processes as inflammation, endothelial dysfunction, mitochondrial dysfunction, and multiple modifications of lipid particles. With the increase in life expectancy, mankind is more and more often faced with the unpleasant consequences of atherosclerosis. Atherosclerosis is a precursor to serious health … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 6 Mar 2024 · 5,393 accessesView PDF Cite

Review ArticleOpen accessLong Way of Evaluating Niacin for Atherosclerosis TreatmentAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina, Elizaveta Mikhailovna Pleshko et al.Atherosclerosis is a significant public health challenge, as it is closely associated with a wide range of cardiovascular diseases and complications. Despite its grave implications, the timely detection and treatment of atherosclerosis remain complex tasks due to the intricate pathogenesis involved, which encompasses numerous processes and mechanisms. Extensive research has been conducted to investigate various therapeutic methods and drugs aimed … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 24 Feb 2024 · 5,122 accessesView PDF Cite

Review ArticleOpen accessUnveiling the Impact of Endogenous Sialidases on Human Non-Infectious Disease PathogenesisRaisa Sergeevna Surkova, Anastasia Vladimirovna Poznyak, Dmitry Alexandrovich Kashirskikh et al.In our review, we have compiled existing information regarding the role of endogenous sialidases (neuraminidases) in the initiation and development of various non-infectious processes in humans. Precisely, pathologies of the cardiovascular system, tumor formations, neurological and metabolic disorders, and hereditary diseases. Sialidases appeared to be widely involved in a variety of human pathologies. An increase or decrease in the enzymatic … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 10 Feb 2024 · 4,546 accessesView PDF Cite

Review ArticleOpen accessFemale Sex Hormones Contribute to Vulnerability to Athero-Sclerosis: Overview of Mechanisms and Specific Risk FactorsAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina, Alexandra Alexandrovna Melnichenko et al.Atherosclerosis poses a significant challenge to the general population, with its prevalence particularly prominent among older individuals. Age, however, is not the sole determinant of risk, as gender also plays a crucial role. Sex-related disparities exist not only in the incidence of atherosclerosis but also in its progression and development. The intricate interplay of hormones in the female reproductive system … …OnLine Journal of Biological Sciences, Vol. 24, Issue 2 · 11 Jan 2024 · 4,633 accessesView PDF Cite

Review ArticleOpen accessOverview of the Most Popular Currently Used Murine Models of AtherosclerosisAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina, Alexandra Alexandrovna Melnichenko et al.Atherosclerosis is a widespread and serious problem. Every year it causes a huge number of deaths and morbidity. Many aspects of this disease remain not fully understood, which indicates the need to search for the most representative model of atherosclerosis in animal and cell culture models. Animal models resembling the pathophysiology in humans are needed to study the immunometabolic mechanisms … …OnLine Journal of Biological Sciences, Vol. 24, Issue 2 · 4 Jan 2024 · 4,669 accessesView PDF Cite