Long Way of Evaluating Niacin for Atherosclerosis Treatment
Anastasia Vladimirovna Poznyak1, Victoria Alexandrovna Khotina2, Elizaveta Mikhailovna Pleshko3, Vasily Nikolaevich Sukhorukov3, Victor Yurievich Glanz3 & Alexander Nikolaevich Orekhov3 Show affiliations
- Laboratory of Angiopathology, Institute for Atherosclerosis Research, Moscow, Russia
- Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, Moscow, Russia
- Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, Moscow, Russia
OnLine Journal of Biological Sciences, Volume 24, Issue 3, pp. 349–357 · doi.org/10.3844/ojbsci.2024.349.357
Abstract
Atherosclerosis is a significant public health challenge, as it is closely associated with a wide range of cardiovascular diseases and complications. Despite its grave implications, the timely detection and treatment of atherosclerosis remain complex tasks due to the intricate pathogenesis involved, which encompasses numerous processes and mechanisms. Extensive research has been conducted to investigate various therapeutic methods and drugs aimed at targeting both the overall progression of the disease and specific pathogenic mechanisms. Recognizing the multifaceted nature of atherosclerosis, comprehensive treatment approaches have emerged as essential in effectively managing the condition. This review provides a thorough examination of the mechanisms underlying the action of niacin, a potential therapeutic agent, in the treatment of atherosclerosis. By illuminating the specific modes of action of niacin, this review contributes to our understanding of its promising role as a treatment modality for atherosclerosis and offers insights into its potential clinical applications.
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Poznyak, A. V., Khotina, V. A., Pleshko, E. M., Sukhorukov, V. N., Glanz, V. Y. & Orekhov, A. N. (2024). Long Way of Evaluating Niacin for Atherosclerosis Treatment. OnLine Journal of Biological Sciences, 24(3), 349–357. https://doi.org/10.3844/ojbsci.2024.349.357
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