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85 results for “Underlying Mechanism”
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Research ArticleOpen accessIn the abstractEffects of Maize Potato Intercropping and Different Fertilization Methods on Rhizosphere Soil Microorganisms and Yield of PotatoHuanjin Ma, Shengguang Xu et al.A field experiment with three replicates was conducted to explore the effects of maize-potato intercropping and different nitrogen application strategies on rhizosphere soil microorganisms and potato yield. Microbial community analysis was based on relative abundance. Maize-potato intercropping improves land use efficiency, yet how differentiated nitrogen management regulates rhizosphere microecology and potato productivity in this system remains unclear. Clarifying nitrogen-mediated shifts … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 3 · 14 Sep 2026 · 790 accessesView PDFCite
Research ArticleOpen accessIn the abstractDecoding Lung Cancer: PLAU as a Critical Driver and Diagnostic MarkerStanley Cho, Min Gyeong KimLung cancer remains a leading cause of cancer-related mortality, and understanding its underlying molecular mechanisms is critical for developing targeted therapies. We developed a novel tool called the Transcriptome-TCGA Integration (TTI), which combines in vitro transcriptome data with clinical datasets from the Cancer Genome Atlas (TCGA). TTI allows for the identification of key genes and pathways involved in lung cancer, … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 15 Feb 2026 · 1,424 accessesView PDFCite
Literature ReviewOpen accessIn the abstractCorrelation of Atherosclerosis and Osteoarthritis, the Role of Inflammation in the Pathogenesis of Osteoarthritis and AtherosclerosisAnastasia V. Poznyak, Nikolay A. Orekhov, Aleksandra Sergeevna Utkina et al.Cardiovascular Diseases (CVD) rank among the leading causes of death globally, accounting for a substantial proportion of mortality rates and affecting millions of individuals. Risk factors such as ageing, obesity, diabetes and a sedentary lifestyle contribute significantly to the prevalence of CVD. Osteoarthritis (OA), on the other hand, is one of the most common joint disorders, affecting a large segment … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 15 Feb 2026 · 1,769 accessesView PDFCite
Literature ReviewOpen accessIn the abstractPotential Therapies for Mitochondrial Diseases Caused by mtDNA MutationsAnastasia V. Poznyak, Nikolay A. Orekhov, Dmitry Felixovich Beloyartsev et al.Mitochondrial diseases, caused by mutations in mitochondrial DNA (mtDNA), present significant genetic and clinical complexities that challenge accurate diagnosis and treatment. This review examines the critical molecular mechanisms underlying these disorders, particularly the role of heteroplasmy, where mixtures of mutated and normal mtDNA influence disease severity, and the nuclear-mitochondrial DNA interactions that compound diagnostic and therapeutic challenges. The threshold effect, … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 15 Feb 2026 · 1,735 accessesView PDFCite
Research ArticleOpen accessIn the abstractEpigenetic Regulation of Extracellular Matrix Remodeling in Skin Aging: Mechanisms and InteractionsJiguang Yang, Yusong Shi, Xiaoqing YanSkin aging results from complex interactions between genetic factors, environmental stressors, and epigenetic modifications that regulate extracellular matrix (ECM) remodeling. Accumulation of senescent cells impairs tissue regeneration through mechanisms including telomere shortening, reactive oxygen species accumulation, and ultraviolet (UV) radiation exposure. While epigenetic pathways regulate skin homeostasis, regeneration, and senescence, the specific epigenetic changes occurring during UV exposure, chronological aging, … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 15 Feb 2026 · 1,458 accessesView PDFCite
Research ArticleOpen accessIn the abstractDihydroartemisinin Attenuates HBV-Induced Proliferation and Migration in LO2 cells via EMT Pathway ModulationYingde Nong, Caifang Ma, Wei Huang et al.Dihydroartemisinin (DHA), a derivative of artemisinin, possesses well-documented anti-inflammatory properties. This study investigated the inhibitory effects of DHA on hepatitis B virus (HBV)-induced cellular alterations in LO2 cells and elucidated underlying molecular mechanisms. Serum interleukin-6 (IL-6) levels were measured in HBV patients and analyzed for correlations with HBsAg, anti-HBs, and HBeAg. In vitro, LO2 cells were infected with clinical HBV … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 8 Jan 2026 · 2,071 accessesView PDFCite
EditorialOpen accessIn the abstractEditorial Commentary: Challenge of Non–AIDS-Defining Cancers (NADCs), Focusing on Trans Activation Response Element (TAR) RNA Embedding ExosomesLechuang Chen, Ge JinGlobally, 37.9 million people were living with HIV at the end of 2018 (Organization, 2018). Cancer is a major cause of mortality and morbidity in AIDS patients and chronically HIV-infected people. With the aid of combination Antiretroviral Therapy (ART), people living with HIV (PLWH) have a longer life span. However, because the virus is not completely eradicated, PLWH under antiretroviral … …American Journal of Immunology, Vol. 15, Issue 1 · 28 Nov 2019 · 6,657 accessesView PDFCite
Research ArticleOpen accessIn the abstractTelomere Length and Gut Microbiota: Integrating Advanced Glycation End Products (Ages) With Artificial Intelligence for Understanding Premature AgingDiniwati Mukhtar, Hanifah HafsariPremature aging is characterized by an accelerated decline in biological functions, increasing the risk of chronic diseases. This review explores the interconnected roles of three critical biomarkers: Telomere Length, gut microbiota composition, and Advanced Glycation End Products (AGEs). These biomarkers exhibit bidirectional relationships, influencing one another and contributing to the aging process. Understanding their interplay provides valuable insights into the … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 3 Sep 2025 · 5,619 accessesView PDFCite
Review ArticleOpen accessIn the abstractSalt Tolerance and Cultivation Challenges of Jojoba (Simmondsia chinensis): A ReviewHeba Allah Adel MohassebJojoba is considered to be salt tolerant, but little is known about the extent of its tolerance and the relative influence on ion uptake and ethylene production and other factors are affecting the mode of actions of jojoba salt tolerant. According to many research has done before including our article about the glyoxalase I gene from jojoba which exhibits moderate … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 12 Jun 2025 · 3,314 accessesView PDFCite
Research ArticleOpen accessIn the abstractAdding Duckweed (Lemna minor) to Local Duck Diet: Determined Based on the Performance and Heavy MetalConcentration in their MeatSyamsuhaidi, Dwi Kusuma Purnamasari, Ryan Aryadin Putra, Uhud AbdullahAn experiment was conducted to determine whether addingduckweed fertilized with bioslurry to the diet corresponds to duckperformance and heavy metal concentration in their meat. The study wasdesigned using a completely randomized design. The treatments weredifferent levels of adding duckweed as a diet component, as follows: Basalfeed (control, no duckweed, TC), basal feed +2.5% duckweed (TL1), basalfeed +5% duckweed (TL2), basal … …American Journal of Animal and Veterinary Sciences, Vol. 20, Issue 1 · 13 May 2025 · 5,839 accessesView PDFCite