50 results for “Trial Design”

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Research ArticleOpen accessIn the abstractEvaluation of Trap Size, Trap Entrance Size and Methyl Eugenol Amount for the Catch of Bactrocera Dorsalis HendelAndi Nasruddin, Iftitah Kartika Amaliah, Julisa et al.The Oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), is a damaging pest of fruit and vegetable crops in many tropical and sub-tropical countries. In Indonesia, the fly is a serious pest of pepper that can cause total yield loss. The purposes of the current study were to determine: (1) The effect of trap size and Methyl Eugenol (ME) amount … …OnLine Journal of Biological Sciences, Vol. 22, Issue 2 · 26 Jun 2022 · 6,379 accessesView PDF Cite

Research ArticleOpen accessIn the abstractBlood Metabolites, Feed Utilization and Performance in Thai Native X Lowline Angus Crossbred Cattle Fed Cassava ByproductsSophany Morm, Areerat Lunpha, Ruangyote Pillajun, Anusorn CherdthongThe purpose of this study was to assess the effect of dried Cassava top Fermented Cassava pulp (CtFCp) on growth performance, digestibility, ruminal parameters, and blood metabolites in Thai native x low-line Angus crossbred cattle. Twelve females of Thai native x lowline angus crossbred cattle were assigned an Initial Body Weight of 99.50±9.83 kg IBW. Dietary treatments were assigned in … …American Journal of Animal and Veterinary Sciences, Vol. 19, Issue 1 · 22 Dec 2023 · 5,896 accessesView PDF Cite

Research ArticleOpen accessIn the abstractIn vitro Ruminal Cumulative Gas and Methane Production, Enzyme Activity, Fermentation Profile and Nutrient Digestibility on Feed Supplemented with Organic SeleniumMoh. Sofi’ul Anam, Andriyani Astuti, Budi Prasetyo Widyobroto et al.Methane (CH4) emissions are indeed a global environmental concern and ruminants are a significant source of these emissions; however, there is limited understanding regarding the contribution of organic Selenium (Se) in mitigating CH4 emissions. Hence, this study investigated the impact of supplementing organic Se from Selenomethionine (Se-Met) on the in vitro ruminal cumulative gas and CH4 production, fermentation profile, enzyme … …American Journal of Animal and Veterinary Sciences, Vol. 18, Issue 4 · 26 Oct 2023 · 5,215 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAgronomic and Economic Parameter Estimates of Cocoyam as Influenced by Fertilizer and EnvironmentPrince Emmanuel Norman, Yvonne Sylvia Gloria Ethel Norman, Jenneh Fatima BebeleyThe effects of fertilizer and environment on agronomic traits and economic parameters in cocoyam were assessed at the Njala Agricultural Research Centre experimental site during the 2014/2015 and 2015/2016 cropping seasons. The fertilizer types used were 200 kg ha–1 NPK 15-15-15, 2000 kg ha–1 Rabbit Manure (RM), and no fertilizer (control). The trial was established in the open field and … …American Journal of Agricultural and Biological Sciences, Vol. 17, Issue 1 · 24 Nov 2022 · 6,049 accessesView PDF Cite

Research ArticleOpen accessIn the abstractRoute Optimization using Hybrid GRU Learning Model for SDN and Edge-Based VANET TopologySavitha Kumar, Chandrasekar ChinnasamyIntelligent Transportation System (ITS) offersoutstanding features, including security applications and emergency alerts.Unfortunately, ITS limits traffic control services, adaptability, andadjustability due to the traffic volume. Hence, expanding the standard VehicularAd hoc Networks (VANET) framework is a requirement. As a result, in the latestdays, the concept of Software-Defined Networking based Vehicular Ad hocNetworks (SDN-VANETs) has drawn considerable attention, creating VANETssmarter. The SDN-VANETs … …Journal of Computer Science, Vol. 18, Issue 8 · 26 Aug 2022 · 6,160 accessesView PDF Cite

Research ArticleOpen accessIn the abstractATLCEP: A New Integrated Design that Encompasses the Safety and Efficacy Objectives of Phase I/II TrialsRevathi Ananthakrishnan, Stephanie Green, Mark Chang et al.Several designs, such as designs to find the optimal biological dose, the Eff-Tox design and seamless Phase I/II designs, have been proposed to evaluate both drug toxicity and efficacy as alternatives to the traditional paradigm of a stepwise drug development approach. Here, we first examine the effect of sample and cohort size on the accuracy of dose selection in early … …Current Research in Biostatistics, Vol. 7, Issue 2 · 7 Apr 2018 · 7,980 accessesView PDF Cite

Research ArticleOpen accessIn the abstractA Bayesian Adaptive Design for Combination of Three Drugs in Cancer Phase I Clinical TrialsMourad Tighiouart, Quanlin Li, Steven Piantadosi, Andre RogatkoWe describe a Bayesian adaptive design for early phase cancer trials of a combination of three agents. This is an extension of an earlier work by the authors by allowing all three agents to vary during the trial and by assigning different drug combinations to cohorts of three patients. The primary objective is to estimate the Maximum Tolerated Dose (MTD) … …Current Research in Biostatistics, Vol. 6, Issue 1 · 25 Aug 2016 · 8,421 accessesView PDF Cite

EditorialOpen accessIn the abstractAre we Able to Harness the Immunomodulatory Power of Cytokines for Novel Autoimmune Disease Treatments?Giuseppe Nocentini, Graziella Migliorati, Carlo RiccardiSince the end of the 1970s, interleukin 2 (IL-2) has been known as a key player in T cell expansion/activation (Watson et al., 1980). In the late 1980s, some groups used IL-2 to stimulate the immune systems of tumour patients (Jacobs et al., 1986). The idea seemed brilliant and several attempts were made, but the results were disappointing (Lim et … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 22 Oct 2015 · 7,625 accessesView PDF Cite

Research ArticleOpen accessIn the abstractOSCILLATORY SYNTHETIC BIOLOGICAL SYSTEM CONSTRUCTION USING INTERACTIVE EVOLUTIONARY COMPUTATIONSQuang Huy Dinh, Nasimul Noman, Hitoshi IbaIn this study, we propose an Interactive Evolutionary Computation system to design gene networks for synthetic biology, of which the objective is to construct new organisms through the artificial synthesis of gene networks. Wet laboratories typically design gene networks through trial and error methods, which makes the construction of complex networks difficult. As a solution, automation can significantly improve the … …Journal of Computer Science, Vol. 10, Issue 12 · 14 Jan 2015 · 8,476 accessesView PDF Cite

Research ArticleOpen accessIn the abstractDietary Beta-1,3/1,6-Glucans Reduce Clinical Signs of Canine AtopyA. C. Beynen, D. H.J. Saris, P. M. Paap et al.Problem statement: There was evidence that beta-1,3/1,6-glucans modulate inflammatory activity. In an open, non-controlled trial, purified beta-1,3/1,6-glucans were found to improve the clinical signs of dogs with undefined chronic skin disorders. Given the design of that study, further work was required on the efficacy of beta-1,3/1,6-glucans in the treatment of canine atopy. Approach: The influence of a purified preparation of … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 9 Jan 2012 · 9,979 accessesView PDF Cite