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31 results for “Oral Toxicity”
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Research ArticleOpen accessIn the abstractThe Effect of Bovine Cartilage on the Growth of Mouse B16F10 Melanoma Cells in vitro and in vivoArax Tanelian, Dalal F. Jaber, Nayla S. Al Akl, Alexander M. AbdelnoorEarlier reports indicated that Bovine Cartilage (BC) had anti-tumor effects but only a few in vitro and in vivo investigations were conducted to assess its mechanism of action. The aim of this study was to investigate some of the proposed mechanisms of action of BC on mouse melanoma cells both in vitro and in vivo and to determine if its … …American Journal of Immunology, Vol. 12, Issue 3 · 26 Oct 2016 · 7,491 accessesView PDFCite
Review ArticleOpen accessIn the abstractSelected Genotoxic Impurities Profiling During WFI Qualification to Control Carcinogenesis in Large Volume ParenteralsMohabbat UllahWater For Injections (WFI) which is the main vehicle of Large Volume Parenterals (LVPs) should be free from trace amount of genotoxic impurities. This review gives emphasis on quantification of genotoxic trace metals during qualification of WFI in LVPs manufacturing unit. According to ICH guidelines, impurities related to drug substances are classified into three main categories: Organic impurities, inorganic (elemental) … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 1 · 27 May 2015 · 7,710 accessesView PDFCite
Research ArticleOpen accessIn the abstractFrom Humans to Dogs and Back: The Translational Lesson of Metronomic ChemotherapyAlessio Pierini, Guido Bocci, Mario Giorgi et al.The main priority in veterinary oncology is to maintain patient quality of life. It is important that new chemotherapy strategies aim to minimize side effects, thus making the treatment attractive for owners as well as their pets. Metronomic chemotherapy has been shown to have an important stabilizing effect on human cancer (including chemotherapy-resistant disease) resulting in prolonged clinical benefit. In … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 4 · 31 Dec 2012 · 7,743 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtection of Terminalia belerica Roxb. Against Iron Overload Induced Liver Toxicity: An Account of Its Reducing and Iron Chelating CapacityBibhabasu Hazra, Rhitajit Sarkar, Nripendranath MandalExcess iron deposition in the liver catalyses the production of Reactive Oxygen Species (ROS) which in turn initiate oxidative damage of protein and nucleic acids leading to several human diseases. The fruits of Terminalia Belerica Roxb. (TB) has been most commonly used not only in stimulating gastrointestinal health, but also in treatment of various hepatic disorders. The present study was … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 20 Nov 2012 · 7,993 accessesView PDFCite
Research ArticleOpen accessIn the abstractAcute and Subchronic Toxicity of Mulberry FruitsJintanaporn Wattanathorn, Wipawee Thukummee, Cholathip Thipkaew et al.At present, the application of phytomedicine worldwide is substantial increase. The data of the acute and subchronic toxicity studies on medicinal plants or fruits and vegetables used for medicinal purposes should be obtained in order to increase the confidence in its safety to human, particularly for the application as functional food. Despite the widely consumption of mulberry (Morus alba L, … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 3 · 19 Sep 2012 · 33,916 accessesView PDFCite
Research ArticleOpen accessIn the abstractToxicological Evaluation of Murraya Paniculata (L.) Leaves Extract on RodentsR. K. Goel, C. V. Rao, A. Singh, M. K. GautamProblem statement: Present study was aimed to explore the acute and sub-acute toxicities studies with orally administered 50% ethanolic leaves extract of Murraya paniculata. Approach: Acute toxicity (oral single dose, 50-2000 mg kg-1) includes any mortality and CNS and ANS toxicities in mice while, sub-acute toxicity (100, 200 and 400 mg kg-1, orally and once daily for 28 days) includes … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 9 Jul 2012 · 8,080 accessesView PDFCite
Research ArticleOpen accessIn the abstractToxicological Evaluation of Aspilia Africana Leaf Extracts in MiceO. O.K. Oko, E. A. Agiang, E. E. Osim, O. R. AsuquoProblem statement: The degree of toxicity of crude extracts of Aspilia Africana (Bush marigold) leaf on the basis of routes and dosages of administration were investigated. 204 healthy, male Swiss albino mice (20-25g) were used in three consecutive studies. Approach: In the first and second study, oral and intraperitoneal doses of 100, 500, 1000, 2000 and 4000 mg kg-1 body … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 3 · 28 Nov 2011 · 8,187 accessesView PDFCite
Research ArticleOpen accessIn the abstractAcute and Sub-Acute Toxicological Assessment of Aqueous Leaf Extract of Bryophyllum Pinnatum (Lam.) in Sprague-Dawley RatsRaymond Iduojemu Ozolua, Sylvester Eshiotseme Idogun, Glory Eshiagiamhe TafamelProblem statement: The aqueous leaf extract of Bryophyllum pinnatum has been reported to possess antihypertensive, antiinflammatory, antimicrobial, antidiabetic and antiulcer properties among others. Being readily available and easy to cultivate, the use of the plant in herbal medicine has been on the increase. Although there are few toxicological reports on the extract, these have not been sufficiently extensive. We therefore … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 3 · 30 Sep 2010 · 9,385 accessesView PDFCite
Research ArticleOpen accessIn the abstractUsing Bioequivalence Approach to Assess Toxicity Effect of Herbal Products, TyrelTM and RumbionTMChunhao Tu, Woon Yuen KohProblem statement: Herbal products have been widely used in veterinary healthcare. Recently, an experiment was conducted in the Natural Animal Facility Pvt. Ltd., Bangalore, India on ten Albino Wistar female mice to assess the acute oral toxicity of two herbal products, TyrelTM and RumbionTM. However, the researchers did not evaluate the toxicity effect of the two products in terms of … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 7,826 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of the Toxic Effects of Dihydroartemisinin on the Vital Organs of Wistar Albino RatsA. U. Utoh-Nedosa, P. A. Akah, T. C. Okoye, C. O. OkoliProblem statement: The current surge in the use of Artemisinin based Combination Therapy (ACT) in the treatment of falciparium resistant malaria in the tropics and the potentials of Dihydroartemisinin (DHA), a member of the artemisinin family, to produce toxic effect in the vital organs (such as the liver, heart, lungs, intestine, spleen kidney and blood cells) necessitated this research. Approach: … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 9,187 accessesView PDFCite