Toxicological Evaluation of Murraya Paniculata (L.) Leaves Extract on Rodents

Problem statement: Present study was aimed to explore the acute and sub-acute toxicities studies with orally administered 50% ethanolic leaves extract of Murraya paniculata. Approach: Acute toxicity (oral single dose, 50-2000 mg kg^-1) includes any mortality and CNS and ANS toxicities in mice while, sub-acute toxicity (100, 200 and 400 mg kg^-1, orally and once daily for 28 days) includes any change in body weight, food and water intake and other biochemical, hematological and histopathological changes in tissues (liver, kidney, spleen, stomach, heart and lung) in rats. Results: Acute oral administration of M. paniculata extract (2000 mg kg^-1, single dose) did not show any mortality and CNS and ANS toxicities. Similarly sub-acute oral administration (100, 200 and 400 mg kg^-1 for 28 days) in rats did not show any change in body weight, food consumption, water intake and biochemical, hematological and histopathological parameters compared to control untreated group. Conclusion: The conclusions of the present study indicate Murraya paniculata to be safe in its oral effective dose.