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31 results for “Oral Toxicity”
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Research ArticleOpen accessPhrase in the titleEvaluation of Acute Oral Toxicity Induced by Tablets Based on Ethanolic Extract of Salvia dumetorum Leaves in Experimental RatsYana Levaya, Karakoz Badekova, Mussa Zholdasbayev, Gayane AtazhanovaThe aim of this study was to assess the acute oral toxicity of a solid dosage form based on Salvia dumetorum Andrz. ex Besser leaf extract (SDT5) in experimental rats. Acute toxicity was evaluated over a 14-day observation period following a single oral administration at three dose levels (500 mg/kg, 1000 mg/kg, and 2000 mg/kg), prepared in 0.5 mL of … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 23 Jun 2026 · 1,245 accessesView PDFCite
Research ArticleOpen accessPhrase in the titlePhysicochemical Characteristics and Sub Chronic Oral Toxicity of Pistacia lentiscus L. Vegetable Oil in RabbitsMaameri Zineb, Zouhir Djerrou, Sofiane Habibatni et al.Pistacia lentiscus vegetable oil is a well known natural product in Algerian traditional medicine. It is widely used in the treatment of back pain, respiratory problems and skin burns. The aim of this study was the determination of some physicochemical parameters and the investigation of sub-chronic oral toxicity of this fatty oil in rabbits. The physico-chemical parameters obtained for this … …OnLine Journal of Biological Sciences, Vol. 16, Issue 1 · 13 Jan 2016 · 7,470 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleThe 100-Days Oral Toxicity of Tomato Pomace in Healthy MiceWathita Phachonpai, Supaporn Muchimapura, Jintanaporn Wattanathorn et al.Problem statement: Growing attention is being paid to functional food. The beneficial effect of functional food appears to relate to its bioactive ingredient such as substances containing antioxidant. Therefore, the information about the toxicity of the substances is very much essential to recommend the safety for the substances implication in both clinical and application trials. Herein, we have investigated for … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 1 · 23 May 2012 · 7,604 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleToxicity of Zinc Oxide Nanoparticles in Lung Tissue After Repeated Oral AdministrationAtaollah Shokouhian, Saman Soheili, Saeed Moradhaseli et al.Pathological experiments should be considered following oral administration of ZnO. Effect of different doses of ZnO nanoparticle on LDH in oral method showed significant differences in control group (p<0.05) at high dose. Levels of IgG, TNF-α and IL-6 also elevated after administration of ZnO. The level of GSH decreased significantly. Lung damages included hyperemia and bleeding, atelectasis, light emphysema, pribronchiolitis, … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 21 Oct 2013 · 7,709 accessesView PDFCite
Research ArticleOpen accessIn the keywordsSafety Assessment of Herbal Formulations, Rumbion™ and Tyrel™ in Albino Wistar RatsA.J. Joshua, K.S. Goudar, N. Sameera et al.Problem statement: Herbal remedies form one of the effective strategies for management of livestock healthcare. Despite the availability of extensive pharmacological information, the toxicological data on herbs and herbal preparations seem to be scanty. The objective of the present investigation was to evaluate the acute oral toxicity of some herbal veterinary preparations in albino Wistar rats. Approach: In the sighting … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 1 · 31 Mar 2010 · 8,551 accessesView PDFCite
Case ReportOpen accessIn the abstractSurvival Following Severe Paraquat Poisoning a Case Study from the Andaman and Nicobar IslandsShiv Shankar Singh, Colin Sanchez, Prasan Kumar PandaParaquat poisoning continues to pose a significant public health challenge in the Andaman and Nicobar Islands, largely due to its alarmingly high mortality rate. In this report, we present the case of a 39-year-old male farmer who ingested 30 mL of paraquat with the intent of suicide. Initially, the patient underwent prompt gastric lavage and exhibited relative stability. Upon admission, … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 22 Jan 2025 · 10,617 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 13,008 accessesView PDFCite
Research ArticleOpen accessIn the abstractHepato and Nephrotoxicity Caused by Sub-Chronic Exposure to Relevant Concentrations of Human Exposure to Glyphosate-Based Herbicide: An Experimental Study in RatsFernanda de Maria Serra, Letícia Rocha Magalhães, Beatriz Bertholace Magalhães Silva et al.Glyphosate's remarkable effectiveness in weed control has made it among the foremost widely employed herbicides globally. Several Glyphosate-Based Herbicides (GBHs) contain 1-4 dioxane, a compound known to induce cancer in animals and potentially contribute to liver and kidney damage in humans. The objective was to assess the liver and kidney toxicity resulting from sub-chronic exposure to GBH in rats. Eighty … …OnLine Journal of Biological Sciences, Vol. 24, Issue 2 · 26 Dec 2023 · 5,198 accessesView PDFCite
Research ArticleOpen accessIn the abstractToxicological Study of Hydroalcohol Leaf Extract of Acanthospermum hispidum (Asteraceae)Diallo Aboudoulatif, Dowou Salem, Badjabaissi Essotolom et al.Acanthospermum hispidum is a widely plant used in African traditional medicine. This study aims to assess cardiotoxicity and sub-chronic (28-days) oral toxicity of hydroalcohol leaf extract of A. hispidum. The sub-chronic toxicity was evaluated after administering daily oral doses of 500 and 1000 mg/kg body wt., for 28 days to the rats, biochemical and haematological assessments as well as body … …American Journal of Pharmacology and Toxicology, Vol. 15, Issue 1 · 16 Mar 2020 · 7,757 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtective Effect of Curcumin Against Hepatic Toxicity Induced by Lithium Carbonate (Li2 Co3)Gehan B.A. Youssef, Ahlam F. Hamoda, Rabab R. Elzoghby et al.The current work was done on four groups of rats (10 for each) to detect the hepato-protective characters of curcumin on the toxicity induced by lithium carbonate. The oral administration of Li2 Co3 for one-month lead to noticeable decrease in the SOD, CAT and GSH while the increase in the GPx and some histological changes in the portal tissues including … …American Journal of Pharmacology and Toxicology, Vol. 14, Issue 1 · 31 Jul 2019 · 7,608 accessesView PDFCite