Research ArticleOpen accessIn the abstractTRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASES-AMAZING TOOL FOR GENOME EDITINGAvantika Singh, Vivek Pratap SinghTranscription Activator-Like Effector Nucleases (TALENs) are used to cut specific target DNA sequence in order to knock out a gene or to change its sequence. They are formed by the fusion of TALE protein serving as DNA binding domain along with non-specific DNA cleaving nucleases. Its specificity towards DNA bases in the target sequence is derived from the structure of … …OnLine Journal of Biological Sciences, Vol. 13, Issue 3 · 4 Sep 2013 · 7,997 accessesView PDFCite
Research ArticleOpen accessIn the abstractMaternal Infection and Neurodevelopmental Disorders in the OffspringHeping ZhouProblem statement: Neurodevelopmental disorders such as schizophrenia and autism have been attributed to both genetic and environmental factors. Whether and how maternal infection as an environmental factor contributes to the development of neurological abnormalities in the offspring remains to be clearly defined. Approach: The literature was reviewed to examine the relationship between maternal infection and neurological disorders such as schizophrenia … …American Journal of Immunology, Vol. 8, Issue 1 · 12 Mar 2012 · 8,150 accessesView PDFCite
Research ArticleOpen accessIn the abstractVoltage-Gated Channels as Causative Agents for EpilepsiesMutasem Abuhamed, Xiao Bo, Kun Xia et al.Problem statement: Epilepsy is a common neurological disorder that afflicts 1-2% of the general population worldwide. It encompasses a variety of disorders with seizures. Approach: Idiopathic epilepsies were defined as a heterogeneous group of seizure disorders that show no underlying cause .Voltage-gated ion channels defect were recognized etiology of epilepsy in the central nervous system. The aim of this article … …American Journal of Immunology, Vol. 4, Issue 4 · 31 Dec 2008 · 6,959 accessesView PDFCite
Research ArticleOpen accessIn the abstractMitochondrial Energy-Deficient Endophenotype in AutismJ. Jay Gargus, Faiqa ImtiazWhile evidence points to a multigenic etiology of most autism, the pathophysiology of the disorder has yet to be defined and the underlying genes and biochemical pathways they subserve remain unknown. Autism is considered to be influenced by a combination of various genetic, environmental and immunological factors; more recently, evidence has suggested that increased vulnerability to oxidative stress may be … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 11,507 accessesView PDFCite
Research ArticleOpen accessIn the abstractEnvironmental Factors and Limbic Vulnerability in Childhood AutismRichard LatheThe rise in prevalence of autism spectrum disorders (ASD) is suggestive of a new etiology. Diagnostic substitution alone is unlikely to account for the increase, while genetic association with detoxification gene alleles points to an environmental contribution. Subtle structural anomalies in the ASD brain are widespread but limbic damage seems important for the development of behaviors diagnostic of ASD. The … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,678 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Role of Neurodevelopmental Genes in Infectious Etiology of AutismS. Hossein FatemiAutism is a neurodevelopmental disorder with both genetic and environmental etiologies. Prenatal infections may play a role in evolution of autism. Experimental evidence shows human influenza viral infection in pregnancy leads to significant deleterious effects in brain structure and function in the developing mouse progeny. Several brain genes of interest in this animal model are also involved in the pathology … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 6,563 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification of Novel Chromosomal Abnormalities, inv(5)(p13q13) and t(7;18)(q32;q21), Associated with AutismZheng Chen, Xiao-bing Zou, Ya-nan Zhang et al.Autism is a neurodevelopmental disorder defined by impairments in social interaction, communication, as well as restricted and stereotyped behaviors. While the etiology of autism remains largely unknown, the existence of genetic components has been clearly demonstrated in autistic pathogenesis. The incidence of autism is 50-100 fold greater in the population with autistic family history than the general population. Chromosomal abnormalities … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 3 · 30 Sep 2007 · 6,773 accessesView PDFCite
Review ArticleOpen accessIn the abstractResveratrol for Atherosclerosis: Potential MechanismsAnastasia Vladimirovna Poznyak, Sergey Kozlov, Gulalek A Babayeva et al.Cardiovascular disease is a big problem around the world. At the heart of most serious cardiovascular diseases is such a pathology as atherosclerosis. Atherosclerosis is a complex set of interactions between inflammation, oxidative stress, lipid disorders, and other molecular, genetic, and lifestyle factors. It is this complexity and multicomponent nature of atherogenesis that make the treatment of atherosclerosis a non-trivial … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 11 Aug 2026 · 605 accessesView PDFCite
Research ArticleOpen accessIn the abstractTen Bioinformatics Tools for Single Nucleotide Polymorphisms DetectionMahin Ghorbani, Hamed KarimiSingle Nucleotide Polymorphisms (SNPs) as unique genetic variations are widely used as biomarkers for drug designing and development for individualized therapy. SNP genotyping techniques such as SBE with MS detection, SBE with fluorescence intensity detection, The FP-TDI, Pyrosequencing and The TaqMan 5’ nuclease assay are low-speed, time consuming and very expensive. To overcome such disadvantages, bioinformatics tools are emerged as … …Current Research in Bioinformatics, Vol. 3, Issue 2 · 10 Apr 2015 · 17,728 accessesView PDFCite