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26 results for “Anticancer Activity”
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Research ArticleOpen accessIn the abstractAnti-Proliferative Activity of Zerumbone Against Tumour Cell LinesAdel Sharaf Al-ZubairiZerumbone (ZER) is a cytotoxic phytochemical component extracted from the tropical herbal plant, Zingiber Zerumbet smith. It has been identified as an active anticancer compound. This study was aimed to evaluate in vitro the anti-proliferative activity of this bioactive compound, zerumbone, on seven cancer cell lines namely: CEMss (T4-lymphoplastoid), Chinese Hamster Ovary (CHO), 3T3 (mouse fibroblast), WEHI-3 (murine monomyelocytic leukemia), … …OnLine Journal of Biological Sciences, Vol. 18, Issue 2 · 25 Apr 2018 · 8,317 accessesView PDFCite
EditorialOpen accessIn the abstractIs Rerum® the New Coley's Vaccine?Marco RuggieroColey's Vaccine and Cancer Immunotherapy Dr. William B. Coley is credited for having been the first to translate the observation of an association between bacterial infections, high fever and cancer remission into a successful cancer treatment. However, it is worth noting that such an association dates back to at least one century before Coley's times; as Wiemann and Starnes from … …American Journal of Immunology, Vol. 13, Issue 2 · 31 May 2017 · 12,281 accessesView PDFCite
Research ArticleOpen accessIn the abstractBioactive Goniothalamin from Goniothalamus tapis with Cytotoxic PotentialKallaya Sangrueng, Saksri Sanyacharernkul, Sirinapa Nantapap et al.Goniothalamus (Annonaceae) is well known for the rich of styryllactone contents and these plants are famous for the potential to be applied as alternative biological activities. The chemical and biological investigations of Goniothalamus tapis is tested for anticancer activities. The research was processioned to extract, isolate, purify and elucidate structure from the leaves and twigs of G. tapis. The isolated … …American Journal of Applied Sciences, Vol. 12, Issue 9 · 4 Oct 2015 · 7,226 accessesView PDFCite
Research ArticleOpen accessIn the abstractCLINICAL EXPERIENCE OF CANCER IMMUNOTHERAPY INTEGRATED WITH OLEIC ACID COMPLEXED WITH DE-GLYCOSYLATED VITAMIN D BINDING PROTEINEmma Ward, Rodney Smith, Jacopo J.V. Branca et al.Proteins highly represented in milk such as α-lactalbumin and lactoferrin bind Oleic Acid (OA) to form complexes with selective anti-tumor activity. A protein present in milk, colostrum and blood, vitamin D binding protein is the precursor of a potent Macrophage Activating Factor (GcMAF) and in analogy with other OA-protein complexes, we proposed that OA-GcMAF could demonstrate a greater immunotherapeutic activity … …American Journal of Immunology, Vol. 10, Issue 1 · 8 Mar 2014 · 13,186 accessesView PDFCite
Research ArticleOpen accessIn the abstractPotential Cancer Chemopreventive Activity of Styryllactones from Goniothalamus marcaniiChalong Mahiwan, Mongkol Buayairaksa, Narong Nuntasaen et al.Goniothalamus plants belonging to the family Annonaceae are found in Thailand and have been used as Thai traditional medicines. Members of this family are rich in a wide variety of biological active compounds including alkaloids, acetogenins and styryllactones. The present research described phytochemical study of the leaves and twigs of G. marcanii together with their cytotoxicity. The G. marcanii was … …American Journal of Applied Sciences, Vol. 10, Issue 1 · 26 Jan 2013 · 7,679 accessesView PDFCite
Research ArticleOpen accessIn the abstractSynthesis, Characterization and Biological Activities of Organotin (IV) Methylcyclohexyldithiocarbamate CompoundsNormah Awang, Ibrahim Baba, Bohari M. Yamin et al.Problem statement: The growing interest in the chemistry of sulphur donor ligands are due to their encouraging anticancer, antibacterial and antifungal activities as well as their widespread industrial application. Dithiocarbamates belong to this class and much attention has been paid to them. Approach: Novel organotin compounds with the molecular formula RmSn[S2CN(CH3)(C6H11)]4-m (where m = 2, R = CH3, C2H5; m … …American Journal of Applied Sciences, Vol. 8, Issue 4 · 18 Apr 2011 · 9,210 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntiproliferative Effects of Alkaloids Isolated from the Tuber of Stephania venosa via the Induction of Cell Cycle Arrest in Mammalian Cancer Cell LinesSirinapa Nantapap, Chatchanok Loetchutinat, Puttinan Meepowpan et al.Problem statement: S. venosa (Menispermaceae) is used in traditional medicine. The constituents of S. venosa belonging to showed remarkable cytotoxic activity. According to previous research, S. venosa contains several alkaloids, such as protoberberine stephanine cyclanoline and N-methylstepholidine, kamaline, (+)-N-carboxamidostepharine, (-)-O-methylstepharinosine, (-)-stepharinosine, aporphine (-)-O-acethylsukhodiamine and oxostephanosine. The chemical and biological investigations of this plant are interesting to bioassay-guided fractionation, particularly Antiproliferative … …American Journal of Applied Sciences, Vol. 7, Issue 8 · 31 Aug 2010 · 8,789 accessesView PDFCite
Research ArticleOpen accessIn the abstractSynthesis and Characterization of Organotin(IV) N-Benzyl-N-Isopropyldithiocarbamate Compounds: Cytotoxic Assay on Human Hepatocarcinoma Cells (HepG2)Normah Awang, Ibrahim Baba, Nor Syaidatul Akmal Mohd Yousof, Nurul Farahana KamaludinProblem statement: Several studies on organotin(IV) dithiocarbamate compounds have been carried out but not on the synthesis and characterization together with cytotoxic assay of organotin(IV) N-benzyl-N-isopropyldithiocarbamate compounds. Approach: Three new organotin(IV) compounds of type N-benzyl-N-isopropyldithiocarbamate have been successfully synthesized by direct reaction between secondary amine with organotin(IV) chloride using in situ method. All the compounds were characterized using elemental analysis, … …American Journal of Applied Sciences, Vol. 7, Issue 8 · 31 Aug 2010 · 8,092 accessesView PDFCite
Research ArticleOpen accessIn the abstractApoptosis of human Breast Cancer Cells induced by Ethylacetate Extracts of PropolisSyamsudin, Partomuan Simanjuntak, Ratna Djamil, Wan Lelly HeffenProblem statement: Propolis has been ethno medically claimed to possess a wide array of biological activities including anticancer activity. The purpose of this research was to verify the folklore claim. Approach: This study was performed in a human breast carcinoma cell, MCF-7. Extract of propolis from different solvent, ethylacetate and n-buthanol showed induced apoptotic cells was detected by flow cytometry. … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 11,587 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification and Antiproliferative Activity Evaluation of a Series of Triterpenoids Isolated from Flueggea virosa (Roxb. ex Willd.)Sod Monkodkaew, Chatchanok Loetchutinat, Narong Nuntasaen, Wilart PompimonProblem statement: Medicinal plants derived anticancer were now being subjects of many research groups especially, the secondary metabolite triterpenoids trees which had enormous potential to inspire and influence modern antiproliferative research. The study aimed to investigate the chemical constitution and their potential use as antiproliferative activity of purified compounds derived from F. virosa. Approach: The F. virosa was selected and … …American Journal of Applied Sciences, Vol. 6, Issue 10 · 30 Oct 2009 · 7,626 accessesView PDFCite