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6 results for “Alexey V. Churov”
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Literature ReviewOpen accessIn the author namesUnraveling NETosis: From Immune Mechanisms to Therapeutic InnovationsAnastasia V. Poznyak, Alexey V. Churov, Gulalek Amanmyradovna Babayeva et al.Neutrophil Extracellular Traps (NETs) are integral to immune responses, serving both protective and pathological roles in inflammatory diseases. Despite increasing recognition of NETs, significant gaps remain in understanding the nuanced mechanisms of NETosis and its implications for health and disease. This review systematically explores NETosis—the formation of NETs—by elucidating the molecular signaling pathways and cellular mechanisms involved. We highlight the … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 21 Feb 2026 · 1,678 accessesView PDFCite
Literature ReviewOpen accessIn the author namesPotential Therapies for Mitochondrial Diseases Caused by mtDNA MutationsAnastasia V. Poznyak, Nikolay A. Orekhov, Dmitry Felixovich Beloyartsev et al.Mitochondrial diseases, caused by mutations in mitochondrial DNA (mtDNA), present significant genetic and clinical complexities that challenge accurate diagnosis and treatment. This review examines the critical molecular mechanisms underlying these disorders, particularly the role of heteroplasmy, where mixtures of mutated and normal mtDNA influence disease severity, and the nuclear-mitochondrial DNA interactions that compound diagnostic and therapeutic challenges. The threshold effect, … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 15 Feb 2026 · 1,735 accessesView PDFCite
Review ArticleOpen accessIn the author namesThe Effect of Main Heat Shock Proteins on AtherosclerosisAnastasia Vladimirovna Poznyak, Alexey V. Churov et al.Atherosclerosis is a multifaceted disease characterized by complex pathogenesis involving diverse mechanisms. In recent years, the autoimmune nature of atherosclerosis has gained significant attention, emphasizing the indispensable role of the immune system in its initiation and progression. Heat Shock Proteins (HSPs) are vital for cellular functionality, facilitating cellular adaptation to environmental changes and survival under adverse conditions. Notably, various HSP … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 3 Oct 2024 · 4,354 accessesView PDFCite
Literature ReviewOpen accessIn the author namesUnveiling the Complex Relationship between Polycystic Ovary Syndrome and Cardiovascular Risk Factors: A Comprehensive ReviewAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina et al.Polycystic ovary syndrome remains a relatively unexplored endocrine disorder with significant implications for female health. Despite its prevalence and known associations with various metabolic disorders, the specific link between polycystic ovary syndrome and cardiovascular risk factors, particularly atherosclerosis, remains inadequately understood. This review aims to address the existing research gap by investigating the connection between polycystic ovary syndrome and cardiovascular … …OnLine Journal of Biological Sciences, Vol. 25, Issue 1 · 2 Oct 2024 · 4,607 accessesView PDFCite