Research ArticleOpen accessIn the keywordsThe Role of Neurodevelopmental Genes in Infectious Etiology of AutismS. Hossein FatemiAutism is a neurodevelopmental disorder with both genetic and environmental etiologies. Prenatal infections may play a role in evolution of autism. Experimental evidence shows human influenza viral infection in pregnancy leads to significant deleterious effects in brain structure and function in the developing mouse progeny. Several brain genes of interest in this animal model are also involved in the pathology … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 6,563 accessesView PDFCite
Research ArticleOpen accessIn the abstractEnhancing DevOps Pipelines With Viral Spread Optimization and Hybrid Deep LearningDileepkumar S R, Juby MathewModern software teams rely on Continuous Integration and Continuous Deployment (CI/CD) pipelines to automate testing and delivery. However, these pipelines often waste resources by running unnecessary tests and failing to predict which builds will fail. This study presents a new framework that addresses three key challenges: (1) deciding which tests to run first, (2) predicting which builds will fail, and … …Journal of Computer Science, Vol. 22, Issue 6 · 3 Jul 2026 · 935 accessesView PDFCite
Research ArticleOpen accessIn the abstractOptimal Control Techniques for the Role of Antiretroviral Therapy (ART) Abuse in HIV/AIDS Treatment DynamicsBassey Echeng Bassey, Adagba Odey HenryFrom the studies of HIV/AIDS transmission and treatment dynamicsusing mathematical modeling, literature reviews have shown that attention hadnot been given to the behavioral attitude of screen-aware infectives not readyto receive treatment, HIV-aware infectives that initiated treatment buttruncated only to resume treatment later (therapy abuse) and those onconsistent treatment protocols. Moreso, following the non-outright eradicationof the deadly HI-virus, recommendations have been … …Journal of Mathematics and Statistics, Vol. 18, Issue 1 · 24 Nov 2022 · 5,819 accessesView PDFCite
Research ArticleOpen accessIn the abstractPrediction of Covid-19 Outbreak in India by Employing Epidemiological ModelsSudheer Reddy K, Anji Reddy V, Mamatha K, Santhosh Kumar CThe novel Corona virus (Covid-19) pandemic has frightened an unprecedented challenge to continents. The Covid-19 pandemic is a highly contagious viral disease that has been progressing across the globe. The global thought leaders, doctors, scientists and other intellects have enforced the lockdown to reduce the spread of the pandemic. The objective is to study the impact of lockdown and to … …Journal of Computer Science, Vol. 16, Issue 7 · 10 Jul 2020 · 6,903 accessesView PDFCite
Literature ReviewOpen accessIn the abstractThe Practical Consideration of Poliovirus as an Oncolytic VirotherapyElizabeth Denniston, Hannah Crewdson, Nicole Rucinsky et al.The inauguration of novel treatment strategies into the clinical setting faces a number of hurdles. In addition to treatment efficacy and safety, acceptance by doctors and patients is paramount to the success of novel therapies. Although viruses are the cause of numerous infectious diseases, these acellular entities have been harnessed over the years to benefit mankind. Recently, a recombinant Poliovirus-Rhinovirus … …Current Research in Virology, Vol. 5, Issue 1 · 3 Mar 2016 · 27,150 accessesView PDFCite
EditorialOpen accessIn the abstractCURRENT SCENARIO OF THERAPEUTICS FOR EBOLA VIRUS DISEASEML Arvinda Swamy, Madhavan P.N. Nair, Shailendra K. SaxenaCurrently various countries in Africa, including Liberia, Sierra Leone, Guinea, Nigeria, are facing disaster due to Ebola Virus Disease (EVD), which is primarily caused by Ebola virus. 2014 outbreak of Ebola associated viral haemorrhagic fever has 55-60% fatality rate. The incubation period of Ebola is below 21 days; once the appearance of symptoms starts the person will be infective. As … …American Journal of Infectious Diseases, Vol. 10, Issue 3 · 3 Sep 2014 · 7,744 accessesView PDFCite
Research ArticleOpen accessIn the abstractCELL DETACHMENT BY PROLYL-SPECIFIC ENDOPEPTIDASE FROM WOLFIPORIA COCOSNicole Mika, Katharina Cierpka, Michaela C. Lange et al.As requirements for Advanced Therapy Medicinal Product (ATMP) production differ from other production processes (e.g., therapeutic protein production), cell detachment is often a crucial step for the process success. In most cases, cell detachment is done enzymatically. Although many peptidases are established in cell culture in R&D, e.g., Trypsin as gold standard, many of them seem to be unsuitable in … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 1 · 8 Feb 2014 · 8,157 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Flavonoid, Quercetin, Inhibits HIV-1 Infection in Normal Peripheral Blood Mononuclear CellsMadhavan P.N. Nair, Zainulabedin M. Saiyed, Nimisha H. Gandhi, C. N. RamchandProblem statement: Flavonoids and related polyphenols, have been known to possess cardioprotective, anti-tumor, anti-inflammatory, anti-allergic and anti-viral activities. Previous studies have shown that flavonoid, quercetin significantly downregulates expression of pro-inflammatory cytokines in cultured cells via modulation of NFκB and p38MAPK signaling pathways. In the current study, we hypothesize that quercetin exerts anti-HIV activity by differential modulation of pro-and anti-inflammatory cytokine … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 12,184 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunodeficient Parameters in the HIV-1 Transgenic Rat ModelSulie L. Chang, Frank Ocasio, Jose A. BeltranRecently an HIV-1 transgenic (HIV-1Tg) rat model was created that carries a gag-pol-deleted HIV-1 genome under the control of the HIV-1 viral promoter. However, other viral proteins are expressed in most organs and tissues, and are found in the circulating blood. Since HIV-1 targets the immune system in humans, we examined two immunological parameters, leukocyte-endothelial adhesion (LEA) and inflammatory cytokine … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 7,834 accessesView PDFCite