5 articles for “tumor vaccines”

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Research ArticleOpen accessIn the keywordsCytokines as Adjuvants for Vaccine and Cellular Therapies for CancerChristian M. Capitini, Terry J. Fry, Crystal L. MackallProblem statement: The development of a potent vaccine that can help treat tumors resistant to conventional cytotoxic therapies remains elusive. While part of the problem may be that trials have focused on patients with bulky residual disease, the desire to maximize responses to the vaccine remains. Approach: The gamma (γ) family of cytokines offered a unique opportunity to support the … …American Journal of Immunology, Vol. 5, Issue 3 · 30 Sep 2009 · 14,351 accessesView PDF Cite

EditorialOpen accessIn the abstractIs Rerum® the New Coley's Vaccine?Marco RuggieroColey's Vaccine and Cancer Immunotherapy Dr. William B. Coley is credited for having been the first to translate the observation of an association between bacterial infections, high fever and cancer remission into a successful cancer treatment. However, it is worth noting that such an association dates back to at least one century before Coley's times; as Wiemann and Starnes from … …American Journal of Immunology, Vol. 13, Issue 2 · 31 May 2017 · 12,285 accessesView PDF Cite

Research ArticleOpen accessIn the abstractVitamin D: The Immunologic Role and its Effect on Human PathophysiologyWilliam Whalen, Edward Werner Cook, Nitya G. ChakrabortyThere are several reasons why understanding the role of vitamin D in the immune system is worthy of widespread attention. Our knowledge of the immune system is crucial for understanding human health and disease. New ideas for vitamin D and life style in the twenty-first century build directly on our understanding of immunology-from the development of new immune-based cancer drugs … …American Journal of Immunology, Vol. 11, Issue 1 · 5 May 2015 · 6,985 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCancer Chemotherapy and Immune RegulationJohn Barrett, Katarina Le BlancProblem statement: Chemotherapeutic drugs have been used to treat malignancy for over 50 years, but the potential of cytotoxic agents to suppress immunity and interfere with Immunosurveillance (IS) of cancer has been largely ignored. Assuming that the immune control of the cancer had a priori already failed, the effect was not considered to have a major impact on treatment outcome. … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Mar 2009 · 40,670 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCancer may be caused by the Immune ReactionRichmond T. PrehnHormesis-like effects of immunity have been documented during tumor-growth experiments in mice, quantitatively large immune-reactions have inhibited while lesser quantities of the same specific immune-reactants have been stimulatory to the growth of implanted tumors. Likewise, carcinogenesis has been inhibited by a high quantities of immune reactants, but positively stimulated by lower levels of the same reactants. One observation suggests that … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,462 accessesView PDF Cite