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6 results for “tail-flick test”
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Research ArticleOpen accessIn the keywordsThe Intracerebroventricular Administration of W-7, A Calmodulin Inhibitor, Attenuate the Development of Morphine Tolerance in RatsGholamreza Sepehri, Vahid Sheibani, Afrooz Azarang et al.Problem statement: The present study was performed to determine the effect of Intracerebroventricular (ICV) administration of W-7, a specific calmodulin inhibitor, on the analgesic effect and development of tolerance to antinociceptive effect of acute and chronic morphine administration respectively. Approach: This study was carried out on male wistar rats, weighing 200-250 g. For acute experimental protocol, Morphine was injected intraperitonealy … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 7,752 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Antinociceptive Effects of Central and Peripheral Administration of Peganum harmala L. Extracts in Animal ModelsRachida Aboufatima, Loubna Farouk, Mehdi Ait Laaradia et al.The medicinal plant Peganum harmala has been used in traditional Moroccan medicine to accelerate the healing process of various diseases and to relieve the pain. The antinociceptive effect of the Aqueous (AE), Dichloromethane (DE) and Butanolic (BE) extracts of the Peganum harmala L. was tested in mice and rats by chemical and thermal models. Plant seed extracts were given intraperitoneally … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 29 May 2021 · 6,423 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntioxidant, Analgesic and Anti-inflammatory Effects of Ethanolic Extract of Moroccan Lavandula stoechas L.Hind Ferehan, Mehdi Ait Laaradia, Sara Oufquir et al.Lavandula stoechas L. is a widely used medicinal plant. In Moroccan traditional medicine, it is employed for the treatment of different illness and as an anxiolytic, analgesic or anti-inflammatory remedy. The purpose of this investigation was to assess the antioxidant, antinociceptive and anti-inflammatory effects of the ethanolic extract of Moroccan Lavandula stoechas L. in animal models. Therefore, in vitro anti-oxidant … …OnLine Journal of Biological Sciences, Vol. 21, Issue 4 · 15 Feb 2022 · 5,889 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Melatonin in Prevention of Neuropathy in STZ-Induced Diabetic RatsNasser Zangiabadi, Vahid Sheibani, Majid Asadi-Shekaari et al.Problem statement: Diabetes mellitus occurs mainly with chronic polyneuropathy, and oxidative stress plays an important role in emergence of most neurologic and behavioral changes in diabetic patients. Many studies have focused on the beneficial effects of various antioxidants such as melatonin on diabetic neuropathy. The aim of this study is to evaluate the effect of melatonin in prevention of neuropathy … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 2 · 17 Sep 2011 · 9,358 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effects of W7, a Specific Calmodulin Inhibitor, to the Antinociceptive Effects of Morphine in Adrenalectomized RatsGholamreza Sepehri, Kayvan Yaghoobi, Vahid Sheibani et al.Problem statement: This study was performed to evaluate the effect of W7 (specific calmodulin inhibitor) on morphine induced analgesia in Adrenalectomized (ADX) rats by tail-flick test. Approach: Tolerance to morphine was induced in male Wistar rats by daily injections of morphine (15 mg kg-1, i.p) for 8 days. Adrenalectomy was performed under general anesthesia with intraperitoneal (i.p) injection of ketamine … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 7,649 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtective Effect of Enicostemma littorale Blume on Rat Model of Diabetic NeuropathyNiraj Mukundray Bhatt, Suparna Barua, Sarita GuptaProblem statement: Poor glycemic control and oxidative stress is implicated as a common pathway in the development of diabetic neuropathy. Approach: In the present study, we investigated the protective effects of Enicostemma littorale Blume (EL) (2.5 g kg-1), a hypoglycemic and antioxidant herbal medicine in alloxan-induced diabetic neuropathy in male Charles foster rats. Results: Tail flick latency in hot immersion … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,838 accessesView PDFCite