Research ArticleOpen accessEvery word in the titleThe Arid3a Transcription Factor Rescues Natural and RAS-V12-Induced Senescence Via a Rb-Dependent PathwayChristian Schmidt, Dongkyoon Kim, Shawn Mathur et al.Primary cells are protected against oncogenic events by undergoing premature cellular senescence—an irreversible cell cycle arrest activated by mitogenic signaling as well as by overexpression of tumor suppressors, including p16INK4A, p53 and PML. In the human, downregulation of Dril1/E2F-BP1, a transcriptional regulator of E2F, promotes PML-dependent premature senescence and bypass of ant-iproliferative signaling by p19Arf/p53/p21Cip1 and p16INK4a to prevent both … …American Journal of Immunology, Vol. 13, Issue 4 · 4 Nov 2017 · 8,396 accessesView PDFCite
Research NotesOpen accessEvery word in the titleNuciferine Attenuates Cigarette Smoke-Induced Senescence in HepG-2 Cells via the miR-217/SIRT1/Nrf2 PathwayYun-Hong Zhao, Yi-Meng Ge, Wei-Jia Xu et al.The lotus leaf, widely used in both medicine and cuisine, contains bioactive compounds with therapeutic potential. Nuciferine (NF), an active constituent of significant importance, is extracted from the lotus leaf. The present study sought to uncover the molecular pathways through which Nuciferine (NF) mitigates cellular senescence triggered by Cigarette Smoke Components (CSCs) in HepG-2 cells, employing an experimental model where … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 2 · 4 Oct 2025 · 2,296 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleThe Triple Immune Argument; Surveillance/Evasion/ Senescence and the Increased Incidence of Acute Myeloid Leukemia Observed with AgeManar M. IsmailAML originates from genetic insults of hematopoietic stem and progenitor cells (HSPCs/HSCs) that was identified earlier as leukemia stem cells (LSCs). In quiescent state, trafficking immune cells are crucial for eradication of aberrant clones and obtaining balance between proliferation and apoptosis to maintain HSCs pool. Regulatory T-cells shield the HSCs from the inflammatory reactions by suppressing T- and B- cells. … …American Journal of Immunology, Vol. 13, Issue 4 · 22 Dec 2017 · 7,806 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEpigenetic Regulation of Extracellular Matrix Remodeling in Skin Aging: Mechanisms and InteractionsJiguang Yang, Yusong Shi, Xiaoqing YanSkin aging results from complex interactions between genetic factors, environmental stressors, and epigenetic modifications that regulate extracellular matrix (ECM) remodeling. Accumulation of senescent cells impairs tissue regeneration through mechanisms including telomere shortening, reactive oxygen species accumulation, and ultraviolet (UV) radiation exposure. While epigenetic pathways regulate skin homeostasis, regeneration, and senescence, the specific epigenetic changes occurring during UV exposure, chronological aging, … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 15 Feb 2026 · 1,458 accessesView PDFCite
Research ArticleOpen accessIn the keywordsPassage Effect on Aging of Human Umbilical Cord Derived Mesenchymal Stem CellDian Mediana, Isabella Kurnia Liem, Jeanne Adiwinata Pawitan, Noviyanti GoeiTo be used in regenerative medicine, cells should be checked for various conditions, including cell aging. This study aimed to learn senescent profile and its relation to cell viability, proliferation and cell size in various passages, which were done in α-MEM-10% PRP medium, until senescence-associated β-galactosidase (SA-β-Gal) positive cells were found. Stem cells were isolated from umbilical cord tissue by … …OnLine Journal of Biological Sciences, Vol. 15, Issue 3 · 31 Jul 2015 · 8,039 accessesView PDFCite
Research ArticleOpen accessIn the keywordsMulberry Fruits Protects Against Age-Related Cognitive DeclineJintanaporn Wattanathorn, Supaporn Muchimapura, Wipawee Thukhammee et al.Problem statement: The phenolic compounds and anthocyanin contents, the antioxidant and Acetylcholinesterase Inhibitor (AChI) activities of mulberry fruits were determined. Approach: Analysis of phenolic compounds and anthocyanin were performed using Folin Ciocalteu reagent and pH-differential method respectively. The antioxidant activity was determined using DPPH and FRAP assays while AChI activity was determined using Ellman method. Results: The mulberry fruit powder … …American Journal of Applied Sciences, Vol. 9, Issue 9 · 8 Aug 2012 · 7,826 accessesView PDFCite
Research ArticleOpen accessIn the abstractSeparation, Purification and Anti-aging Activity of Tobacco PolysaccharidesMengyue Huang, Jingwu Song, Shuaishuai Chang et al.To separate tobacco polysaccharides and investigate their antioxidant and anti-aging properties, crude tobacco polysaccharides were extracted from raw tobacco using hot water, followed by purification through DEAE-52 cellulose column chromatography. The molecular weight and monosaccharide composition of the isolated polysaccharides were analyzed using HPGPC and HPLC. The antioxidant activities of these tobacco polysaccharides were tested using DPPH, ABTS, hydroxyl radicals … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 1 · 15 Jan 2025 · 5,103 accessesView PDFCite
Research ArticleOpen accessIn the abstractPollution Potential Assessment of Nymphaea alba in Nigeen Basin of Dal Lake, Kashmir (J&K), IndiaHina Mushtaq, Shameem Ahmad Shameem, Mumtaz Mohd Bhat et al.The present study was conducted to investigate the biochemical attributes of Nymphaea alba (also known as the European White Water lily or Nenuphar), an annual or perennial aquatic flowering plant at three study sites viz., site I (Nagoo Mohalla, near residential area); site II (Ashaibagh-adjacent to floating gardens) and site III (Marzibagh-Nigeen boat club) in Nigeen Basin of Dal Lake, … …American Journal of Environmental Sciences, Vol. 14, Issue 2 · 8 May 2018 · 8,807 accessesView PDFCite
Research ArticleOpen accessIn the abstractAge-Dependent Variation of Telomere Length and DNA Damage in ChickenMaxim S. Makarenko, Alexander V. Usatov, Lyubov V. Getmantseva et al.Birds are unique models for molecular studies on aging processes and cellular senescence because of their slow rates of aging and comparatively long life spans among homoeothermic animals. The study aimed to examine the relative telomere length and amount of nuclear, mitochondrial DNA lesions in hens of different ages and to find out the correlation between these biomarkers of aging. … …OnLine Journal of Biological Sciences, Vol. 17, Issue 4 · 14 Dec 2017 · 7,505 accessesView PDFCite