Research ArticleOpen accessIn the keywordsAnticonvulsant Effect of Pitavastatin in Mice Induced by PentylenetetrazoleKhayatnouri MirhadiProblem statement: The 3-Hydroxy-3-Methylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have been unequivocally shown to reduce cardiovascular morbidity and mortality by their lipid-lowering actions. It has been suggested that statins appear to have therapeutic benefits in diseases that are unrelated to elevated serum cholesterol levels. The aim of this study was to evaluation the effect of intraperitoneally injection of different doses of … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 11 Jan 2012 · 7,507 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEffect of Phenylbutazone on Pentylenetetrazole-Induced Seizure in MiceKhayatnouri MirhadiProblem statement: The Cyclooxygenases (COXs), the key enzymes that convert arachidonic acid to Prostaglandins (PGs), had been implicated in physiological and pathophysiological functions in the CNS. Non-Stesoidal Anti-Inflammatory Drugs (NSAIDs), COX inhibitors, were used largely to treat febrile condition, pain state and for prevention of and therapeutics of many diseases. However the role of PGs and NSAIDs in the seizure … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 13 Dec 2011 · 7,675 accessesView PDFCite
Research ArticleOpen accessIn the abstractThiosemicarbazide Induces Partial Myoclonic, Generalized Tonic-Clonic and Status Epilepticus Seizures Depending on the Dose in the RatAnwar Satef, Sofia El Amoury, Soumaya El Ganouni et al.The present study aimed to characterize the seizures produced by injections of Thiosemicarbazide (TSC), a glutamic acid decarboxylase inhibitor. It aimed also to evaluate the anticonvulsant effect of the antiseizure medications Phenobarbital (PHB), Valproate (VPA), and Phenytoin (PNT) and of the antipsychotics Chlorpromazine (CPZ) and Haloperidol (HAL) as well as the antidepressant SSRI, Fluoxetine (FXT). Male Wistar rats received TSC … …Neuroscience International, Vol. 13, Issue 1 · 4 Mar 2023 · 10,301 accessesView PDFCite