10 results for “secondary structure prediction”

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Research ArticleOpen accessPhrase in the titleProtein Secondary Structure Prediction using Hybrid Recurrent Neural NetworksRomana Rahman Ema, Akhi Khatun, Md. Alam Hossain et al.The most important and challenging problem in bioinformatics is protein secondary structure prediction. The molecules of all protein organisms have three-dimensional (primary, secondary, 3-D) structures which are completely recognized by the sequence of amino acids. Protein secondary structure attributes to the polypeptide backbone of the local configuration of proteins. Most generally, the second-level prediction is indicated such as: If there … …Journal of Computer Science, Vol. 18, Issue 7 · 14 Jul 2022 · 7,332 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleImproving Protein 3D Structure Prediction Accuracy using Dense Regions Areas of Secondary Structures in the Contact MapAmer F. Al-Badarneh, Mohammad A. Khalil, Mo'taz A. Al-HamiProblem Statement: The protein folding problem is a fundamental problem in structural molecular biology. This problem describes how a protein is transformed from its primary sequence (i.e., amino acid sequence) into the three dimensional structure (3D structure) for this sequence that determines the function of the protein. The 3D structure of a protein can be represented using a square symmetrical … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 4 · 31 Dec 2008 · 7,533 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleLow-Homology Protein Structural Class Prediction from Secondary Structure Based on Visibility and Horizontal Visibility NetworkZhi-Qin Zhao, Liang Luo, Xiao-Yan LiuIn this study, based on the predicted secondary structures of proteins, we propose a new approach to predict protein structural classes (α,β,α/β,α+β) for three widely used low-homology data sets. Fist, we obtain two time siries from the chaos game representation of each predicted secondary structure; second, based on two time series, we construct visibility and horizontal visibility network, respectively and … …American Journal of Biochemistry and Biotechnology, Vol. 14, Issue 1 · 12 Mar 2018 · 9,668 accessesView PDF Cite

Review ArticleOpen accessIn the abstractProtein Sequences Features Extraction for Predicting Beta- Turns and their Types: A ReviewMurtada Khalafallah Elbashir ElfakiBeta-turns are considered to be important secondary structure types that have essential role in molecular recognition, protein folding and stability. They represent 25% of protein structures, therefore they are the most common type of non-repetitive or tight turns structures. Their prediction is considered to be an important issue in bioinformatics and molecular biology, because it provides valuable information and inputs … …Journal of Computer Science, Vol. 15, Issue 9 · 1 Oct 2019 · 7,694 accessesView PDF Cite

Research ArticleOpen accessIn the abstractIn Silico Characterization and Motif Election of Neurotoxins from Snake VenomMahmudul Hasan, Ziaul Faruque Joy, Elius Hossain Bhuiyan, Md Shiful IslamSnake venom is a mixture of many biological components. Snakes usually use their venomic armory to tackle different prey and predators in adverse natural world. Among various components of the snake venom, neurotoxins play an important role in exerting effect by blocking the neuromuscular transmission through selective binding to muscle nicotinic Acetyl-Choline Receptors (nAChR). A set of 30 reference protein … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 2 · 2 Mar 2015 · 7,702 accessesView PDF Cite

Research ArticleOpen accessIn the abstractDESIGN OF CANDIDA ANTARCTICA LIPASE B THERMOSTABILITY IMPROVEMENT BY INTRODUCING EXTRA DISULFIDE BOND INTO THE ENZYMEUsman Sumo Friend Tambunan, Ahmad Randy, Arli Aditya ParikesitCandida Antarctica Lipase B (CALB) is extensively studied in enzymatic production of biodiesel, pharmaceutical products, detergents and other chemicals. One drawback of using CALB is its relatively low optimum temperature at 313 K (40°C). The objective of this research is to design CALB mutant with improved thermostability by introducing extra disulfide bond. Molecular dynamic simulation was conducted to get better … …OnLine Journal of Biological Sciences, Vol. 14, Issue 2 · 18 Apr 2014 · 9,492 accessesView PDF Cite

Research ArticleOpen accessIn the abstractA Survey of Compute Intensive Algorithms for Ribo Nucleic Acids Structural DetectionRa’ed Al-Khatib, Rosni Abdullah, Nur’Aini Abdul RashidProblem statement: Finding an accurate RNA structural alignment from primary sequence due to it is time consuming and computationally NP-hard problem is a major bioinformatics challenge. According to our investigation majority of current researches were concerned on achieving faster execution time, improving space complexity and better cache management. Recently one research introduced cache-efficient Chip Multiprocessor (CMP) algorithms with good speed-up … …Journal of Computer Science, Vol. 5, Issue 10 · 31 Oct 2009 · 6,458 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Meaning of a Redundant Codon: There is Protein Folding Information in Nucleic Acids in Addition to the Genetic CodeJan C. Biro, Josephine M.K. BiroAll the information necessary for protein folding is supposed to be present in the amino acid sequence. It is still not possible to provide specific ab initio structure predictions by bioinformatical methods. It is suspected that additional folding information is present in protein coding nucleic acid sequences, which is not represented by the known genetic code. Nucleic acid subsequences comprising … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 1 · 31 Mar 2006 · 8,292 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordAnchoring Public Health Forecasts: High-Precision Obesity Prevalence Estimation Via Hybrid Geodemographic Ensemble RegressionTrenton Ward, Isaac OsunmakindeObesity remains a major driver of chronic disease and rising healthcare costs in the United States. Yet, most existing predictive models rely on single-model classifiers and rarely incorporate spatial structure or ensemble-based regression, thereby limiting their ability to capture geodemographic variation. This study introduces a hybrid unsupervised–supervised ensemble framework that integrates K-Means spatial profiling with a Stacking Regressor to address … …Journal of Computer Science, Vol. 22, Issue 7 · 31 Jul 2026 · 632 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordIn Silico Sequence Analysis, Structure Prediction and Function Annotation of Melanocortin 1 Receptor Gene (MC1R) from the Guppy Poecilia reticulataAbdul Khader Sultan Mohideen, Mehboob Asrar Sheriff, Kareem AltaffThe common guppy, Poecilia reticulata is one of the most popular aquarium fish used as a model organism in toxicology, embryology and genetical studies. Vibrant colors in males are a secondary sexual character which attracts the females for mating. Pigmentation in guppy is found to be linked with melanin synthesis. Melanocortin genes are involved in the synthesis of melanin pigments. … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 4 · 17 Nov 2015 · 8,614 accessesView PDF Cite