5 results for “route of exposure”

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Research ArticleOpen accessIn the keywordsToxicological Evaluation of Aspilia Africana Leaf Extracts in MiceO. O.K. Oko, E. A. Agiang, E. E. Osim, O. R. AsuquoProblem statement: The degree of toxicity of crude extracts of Aspilia Africana (Bush marigold) leaf on the basis of routes and dosages of administration were investigated. 204 healthy, male Swiss albino mice (20-25g) were used in three consecutive studies. Approach: In the first and second study, oral and intraperitoneal doses of 100, 500, 1000, 2000 and 4000 mg kg-1 body … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 3 · 28 Nov 2011 · 8,184 accessesView PDF Cite

Research ArticleOpen accessIn the abstractOptimized Earthquake Evacuation Routes Using Dijkstra's Algorithm and WinQSBSandra Huarcaya Gonzales, Hugo Vega-Huerta, Gisella Luisa Elena Maquen-Niño et al.This research analyzes and generates optimal evacuation routes in the Barranco district during earthquake scenarios using the Dijkstra algorithm implemented through WinQSB. A preliminary review was conducted to establish key concepts related to earthquake dynamics, evacuation route planning, and the application of Dijkstra’s algorithm. Given its high seismic exposure and the prevalence of aging infrastructure, Barranco is considered highly vulnerable … …Journal of Computer Science, Vol. 21, Issue 10 · 9 Dec 2025 · 2,851 accessesView PDF Cite

EditorialOpen accessIn the abstractImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,158 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Cognitive Enhancing Effect of Tomato PomaceWipawee Thukhammee, Jintanaporn Wattanathorn, Supaporn Muchimapura et al.Poor learning abilities and impaired memory are increasing their importance in accompany with the increased elderly population and stress exposure. Therefore, the development of cognitive enhancement is required. Recent findings showed that oxidative stress played the important role on the development of cognitive impairment in various conditions. Therefore the development of cognitive enhancer from vegetable possessing antioxidant is focused. The … …American Journal of Applied Sciences, Vol. 9, Issue 11 · 31 Aug 2012 · 7,022 accessesView PDF Cite

Research ArticleOpen accessIn the abstractDetermination of the Salivary Anti-Phenolic Glycolipid-1 Antibody in Leprosy Patients as a Tool to Monitoring MultidrugtherapyN. L.B. Bonfitto, A. C.F. Motta, R. B. Furini et al.Problem statement: The upper airways has a great importance as a route of M. leprae infection and because of the possibility of identifying relevant tools by systematic patient evaluation, the detection of leprosy patients by means of salivary markers becomes important. The aim of this study was to analyze anti-phenolic glycolipid 1 (anti-PGL-1) salivary and serum titers as parameters for … …American Journal of Infectious Diseases, Vol. 5, Issue 4 · 31 Dec 2009 · 8,117 accessesView PDF Cite