2 results for “retinal pericytes”

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Research ArticleOpen accessIn the keywordsAttenuated Superoxide Dismutase Induction in Retinal Cells in Response to Intermittent High Versus Continuous High GlucoseMichael A. Ihnat, Ronald C. Kaltreider, Jessica E. Thorpe et al.High glucose, particularly in oscillating conditions, produces an increase in oxidative stress and has been shown to result in an increase in diabetic complications, retinopathy in particular. The hypothesis of this work was that chronic exposure to intermittent high glucose results in an attenuated induction of an antioxidant response as compared to continuous high glucose exposure in isolated retinal cells … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 1 · 31 Mar 2007 · 7,453 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEffects of D- and L-Glucose and Mannitol on Retinal Capillary Cells: Inhibition by Nanomolar AminoguanidineYongxin Yu, Wei Li, Barbara Wojciechowski et al.Hyperglycemia may contribute directly to pericyte loss and capillary leakage in early diabetic retinopathy. To elucidate relative contributions of glycation, glycoxidation, sugar autoxidation, osmotic stress and metabolic effects in glucose-mediated capillary damage, we tested the effects of D-glucose, L-glucose, mannitol and the potentially protective effects of aminoguanidine on cultured bovine retinal capillary pericytes and endothelial cells. Media (containing 5 mM … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 4 · 31 Dec 2007 · 7,749 accessesView PDF Cite