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31 results for “protein-protein interactions”
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Research ArticleOpen accessEvery word in the titleDrug-Protein Interactions for Clinical Research by Nucleic Acid Programmable Protein Arrays-Quartz Crystal Microbalance with Dissipation Factor Monitoring Nanoconductometric AssayClaudio Nicolini, Rosanna Spera, Nicola Luigi Bragazzi, Eugenia PechkovaConductometric monitoring of drug-gene and drug-protein interactions is of fundamental importance in the field of molecular pharmacology. Here, we present our main findings and characterizations of an important antiblastic used in neuro-oncology (Temozolomide), interacting with selected proteins that represent predictive biomarkers of the rate survival of the patients, of the outcome of chemotherapy and resistance to drug itself (namely, BRIP1 … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 17 Nov 2014 · 8,506 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe NifX Protein is Involved in the Final Stages of FeMo-cofactor Transport to the MoFe ProteinSurobhi Lahiri, Byron Cole, Lakshmi Pulakat, Nara GaviniThe nitrogenase enzyme catalyzes the reduction of dinitrogen to ammonia and is composed of the Fe and MoFe proteins. The iron molybdenum cofactor (FeMo-co) of the MoFe protein is the site of active substrate reduction. The NifX protein has also been suggested to have a role in the FeMo-co synthesis, although its exact role is still open to investigation. We … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 2 · 30 Jun 2007 · 7,262 accessesView PDFCite
Review ArticleOpen accessIn the keywordsThe HCV Replicase InteractomeAntonio Mas, Pilar Clemente-Casares, Eugenio Ramírez, Rosario SabariegosViruses are obligate parasites and can only reproduce within host cells because they lack metabolic pathways to complete their replication cycles. Host factors required in viral replication are mainly those involved in lipid metabolism, cell cycle control and apoptosis, cell-to-cell interactions, immune system regulation, etc. Several inhibitors targeting viral polymerases have been designed. However, the rapid appearance of resistant mutants, … …Current Research in Virology, Vol. 5, Issue 1 · 27 Jul 2016 · 13,210 accessesView PDFCite
Research ArticleOpen accessIn the abstractSynergistic Effects of Wheat Bran and Inoculants on Fermentation and Nutritional Quality of Soybean Straw SilageLie Yang, Rundong Qin, Jiahuan Liu et al.The efficient valorisation of lignocellulosic biomass from soybean straw into high-quality silage remains a pressing challenge for sustainable livestock production. This study employed a 3×3 factorial design to systematically investigate the interactive effects between wheat bran additions (0%, 10%, 20% of fresh weight) and microbial inoculant regimes (control, Effective Microorganisms, EM+Trichoderma longibrachiatum) on soybean straw silage quality. Two-way ANOVA revealed … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 1 Jul 2026 · 1,109 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Metal Ions on The Functional Properties of Taro Protein IsolateYouru Huang, Yingtong Li, Zheng Zhang, Maoqiang ZhengThis study investigated the effects of metal ion species and concentrations on the functional properties of taro protein isolate (TPI), extracted from Colocasia esculenta corms. The results demonstrated that metal salt solutions could modulate the unfolding and aggregation of TPI, thereby altering its protein-protein and protein-water interactions and significantly affecting the functional properties. When monovalent cation concentration [M+] was less … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 6 Jan 2026 · 2,012 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn silico and in vitro Structural Analysis on the Interaction of Calmodulin and Calmodulin-Binding Motif of FKBP35 from Plasmodium knowlesiSazlinawatie Aladin, Cahyo Budiman et al.FK506-binding protein 35 (FKBP35) is a peptidyl-prolyl cis-trans isomerase found in Plasmodium knowlesi, a zoonotic malaria parasite responsible for concerning cases of malaria infection in East Malaysia. This protein contains a segment known as the calmodulin-binding motif (Pk-CBM), which is predicted to facilitate interaction with calmodulin from P. knowlesi (Pk-CaM). Although this interaction is considered promising for future antimalarial drug … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 10 Mar 2025 · 4,846 accessesView PDFCite
Review ArticleOpen accessIn the abstractFrom Health to Disease: Functional Insights of Scavenger Receptor Class B Type I in Lipid Metabolism and Disease PathogenesisSujina Simon Sailet, Poornima Ajay Manjrekar, Santosh Rai et al.Scavenger receptor class B type I (SR-B1) has caught considerable interest among the scientific community due to its pivotal role in several biological and pathological processes. It is a multifunctional integral membrane protein and multiligand receptor encoded by the SCARB1 gene. SR-B1 has a wide distribution, primarily in the liver as well as steroidogenic organs including the gonads and adrenal … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 11 Jul 2025 · 3,667 accessesView PDFCite
Research ArticleOpen accessIn the abstractDietary Protein and Energy Levels at 3200 m Altitude for Slow-Growing ChickensMariela Ketty Meza-Morveli, Liz Beatriz Chino-Velasquez, Jesús Camero DeLaCuba et al.The extent to which energy and protein (CP) levels can be reduced without impacting productivity in slow-growing chickens remains undetermined. The treatments were conducted to evaluate the effect of dietary CP (17.5, 19, and 20.5%) and energy (2850-2950 kcal ME/kg) on slow-growing chickens using an ideal protein concept at a high altitude (3200 m). We used a total of 144 … …American Journal of Animal and Veterinary Sciences, Vol. 19, Issue 4 · 20 Dec 2024 · 5,275 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvestigation of the Contribution of Late Embryogenesis Abundant (LEA) K Peptide in Enhancing the Expression of Lipase from Sphingobacterium sp.: In vitro and in Silico StudiesIbrahim Muhammad et al.Sphingobacterium sp. AB3 lipase is a psychrophilic enzyme with optimal lipolytic activity at pH 7 and 15°C. The cold-adapted properties of the lipase render it suitable for various low-temperature industrial applications such as biodiesel production, detergent formulation, and non-thermal food processing. Recent studies have shown that co-expression of LEA K peptide with AB3 lipase resulted in enhanced protein expression in … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 4 · 21 Nov 2024 · 4,569 accessesView PDFCite
Review ArticleOpen accessIn the abstractDrought and Terminal Heat Stress Effects and Its Management on Wheat Genotypes: A ReviewSantosh Gupta, Prabin Kumar Mahato, Naresh Upadhyaya et al.Wheat (Triticum aestivum) is a vital cereal crop that plays a crucial role in global food security, supplying essential calories and protein to over 80% of the world's population. In recent decades, the effects of climate change, particularly rising temperatures, have raised concerns about Wheat production worldwide. The optimal daytime temperature for Wheat growth during its reproductive stage is around … …American Journal of Agricultural and Biological Sciences, Vol. 19, Issue 1 · 21 Nov 2024 · 8,230 accessesView PDFCite