Research ArticleOpen accessIn the keywordsHistone Tail Modifications of H3 and H4 during the Physarum polycephalum Cell CycleMarie-Claire Arnaud, Christophe ThirietProblem statement: Histone modifications are required for chromatin activities and are believed to form an epigenetic code. However, the inheritance of the histone post-translational modifications remains unclear. Approach and Results: The aim of this study was to evaluate the histone modifications throughout the cell cycle and to determine whether the histone marks are transferred to daughter cells. Using the naturally … …OnLine Journal of Biological Sciences, Vol. 12, Issue 2 · 29 May 2012 · 7,580 accessesView PDFCite
Research ArticleOpen accessIn the abstractCloning and Expression of SCAMP3 in Transgenic Silkworm (Bombyx mori)Selly S. Rajagukguk, Sabar Pambudi, Astari Dwiranti et al.SCAMP3 (Secretory Carrier Membrane Protein 3) is a crucial component of vesicular trafficking pathways and plays important roles in endocytosis and protein recycling. Previous studies demonstrate SCAMP3 dysregulation in various cancers, suggesting potential applications as a biomarker and therapeutic target. Understanding SCAMP3 expression and post-translational processing provides insights into its biological functions and potential applications in cancer diagnostics and therapy. … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 16 Feb 2026 · 1,521 accessesView PDFCite
Research ArticleOpen accessIn the abstractOptimizing N-linked Glycosylation Site Prediction in Human Proteins with Ensemble Stacking and Cross-ValidationMubina Malik, Jaimin UndaviaThe most frequent post-translational modification of proteins in all territories is glycosylation which impacts many biological activities. The most significant and critical of these modifications is N-linked glycosylation which is associated with various human diseases including diabetes cancer Inflammation Alzheimers and atherosclerosis. This article illustrates recent advances in knowledge of biology that are eventually targeting the computer science sector. Moreover-identification … …Journal of Computer Science, Vol. 20, Issue 12 · 20 Nov 2024 · 4,999 accessesView PDFCite
Research ArticleOpen accessIn the abstractModel Classification for Predicting the Post-Translational Modification (PTM) Glycosylation in Sequence O Using an Extreme Gradient Boosting AlgorithmDamayanti, Sutyarso et al.Post Translational Modification (PTM) is an important mechanism involved in regulating protein function. Post-translational modification refers to the addition of covalent and enzymatic modifications of proteins in protein biosynthesis, which has an important role in modifying protein function and regulating gene expression. One of the post-translational modifications is glycosylation. Glycosylation is the addition of a sugar group to a protein … …Journal of Computer Science, Vol. 20, Issue 7 · 29 Apr 2024 · 5,554 accessesView PDFCite
Research ArticleOpen accessIn the abstractCancerous Immunoglobulins and CA215: Implications in Cancer ImmunologyGregory LeeImmunoglobulins are typically expressed by B cells in our normal immune system. However, certain normal human tissues, such as hyperplastic epithelial cells, cells of the immunologically privileged sites and the majority of cancer cells, have also been found to be sites of immunoglobulin production. Current research is lacking in regards to the differential immunoglobulin expression, the underling mechanisms of action … …American Journal of Immunology, Vol. 8, Issue 4 · 18 Sep 2012 · 8,942 accessesView PDFCite