2 results for “porphyria”

Set a search alert

Research ArticleOpen accessEvery word in the titleProtective Effects of Covalent Cross-Linking on Proteolysis of Human Coproporphyrinogen Oxidase and Implications for PorphyriaAhmed W. Jafri, Jason R. Stephenson, Justin B. Morgenthaler et al.The effects of covalent cross-linkers on the enzyme, coproporphyrinogen oxidase, had been previously studied but their role in protecting the enzyme from protease cleavage has not been evaluated. Therefore, we examined how the cross-linker bis (sulfosuccinimidyl) suberate (BS3) affects the ability of trypsin to digest purified, wild type recombinant human coproporphyrinogen oxidase and selected mutants. Following incubation, the apparent molecular … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 4 · 31 Dec 2008 · 6,687 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPlasma Bilirubinaemia; A Physiologic Index for Monitoring Cellular Effects of Amalar, Chloroquine, Cotecxin and FansidarE. O. Jimmy, I. F. UsohProblem statement: Antimalaria drugs are highly consumed in Africa due to increase prevalent of malaria attacks. Though the disease is often cured with some antimalarials the physiologic effects of such drugs may not be considered in pharmacologic preparations and in prescriptions. Such non consideration is likely to result in serious health problems which may outweigh the effects of malaria disease … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 7,541 accessesView PDF Cite