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102 results for “polymorphism”
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Research ArticleOpen accessEvery word in the titleAssociation Between Cancer Screening Results Using Single Nucleotide Polymorphism and Cancer Incidence Rate in Korean WomenKyung Bae Lee, Jae Kyung KimIn this study, we investigated the usefulness of Single Nucleotide Polymorphism (SNP) testing in assessing cancer susceptibility in women by evaluating correlations between SNP testing results and cancer incidence rates. SNP testing was conducted on blood samples of women who underwent health examinations commissioned by medical institutions in the Republic of Korea in 2017 using real-time polymerase chain reaction with … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 3 · 25 Sep 2023 · 4,956 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleFrequencies of the C1236T, G2677T/A, and C3435T Polymorphisms of the MDR1 Gene and their Haplotypes in UzbekistanS. B. Nurmatova, A. A. Abdurakhimov, O. S. Charishnikova et al.P-glycoprotein (P-gp) is encoded by the MDR1 gene and is involved in the pharmacokinetics of drugs. The best-known MDR1 gene polymorphisms are 1236C>T, 3435C>T, and 2677G>T/A, which are associated with protein folding, changes in mRNA levels, and drug pharmacokinetics. The aim of this study was to identify the frequency of distribution of functional polymorphisms C1236T, C3435T, G2677T/A of the MDR1 … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 4 · 5 Dec 2022 · 5,022 accessesView PDFCite
Literature ReviewOpen accessEvery word in the titleSystematic Review of Single Nucleotide Polymorphisms of Cattle Beta-Lactoglobulin Gene and their Association with Milk Production TraitsThlarihani Cynthia Makamu, Thobela Louis TyasiThe application of molecular genetics technology to pinpoint certain DNA markers associated with commercially significant features is highly anticipated since it has the potential to enhance the effectiveness of breeding programs by selecting young animals early for use as future breeding stock. One of the main genes expressed in bovine milk is the Beta-Lactoglobulin Gene (βLG), and its polymorphism can … …American Journal of Animal and Veterinary Sciences, Vol. 19, Issue 2 · 4 Mar 2024 · 5,811 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Relevance of Bioinformatic Tools in the Study of Polymorphisms of the B4GALNT2 Gene and its Association with CancerEddaikra Atika, Haddouche Hayet, Touil-Boukoffa ChafiaThe human gene B4GALNT2 encodes an enzyme (β1,4-N-acetylgalactosaminyltransferase II) that controls the expression of the blood group Sda carbohydrate’s antigen. This gene is located in position 17q21,32 and consists of 11 exons. The characterization and understanding of genetic variation is a real challenge in human genetics, both for healthy individuals and diseased ones. The in silico study of the B4GALNT2 … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 27 Feb 2020 · 6,767 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMeasurement of the Gene Expression and Polymorphisms of c-myc and p53 Genes in HBV Infected PatientsFayed Koutb, Salah Abdel-Rahman, Ehab Hassouna, Amany HaggagThis study explained the c-myc and p53 gene expression and polymorphisms in chronic (40), cirrhosis (30) and Hepatocellular Carcinoma, (HCC) (30) patients related to Hepatitis B Virus (HBV) infection and healthy control (50) in Egypt. Where, c-myc (intron 8) and p53 (codon 72) gene expression and polymorphisms were determined using qRT-PCR and PCR-RFLP techniques. The results showed that c-myc gene … …OnLine Journal of Biological Sciences, Vol. 21, Issue 1 · 22 Feb 2021 · 7,229 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMolecular Detection of Follicle Stimulating Hormone Receptor Polymorphisms and Luteinizing Hormone Gene Variations in Primary and Secondary Iraqi Infertile WomenNoor Basim Naser, Dr. Ezeddin Atia Albayyar, Dr. Susan Abed ZaidanThe current study aimed to determine the role of hormonal disturbances in infertility, moreover assessing variations at the molecular level that could affect this disease. The study examined 90 blood samples, 30 patients with primary infertility, 30 patients with secondary infertility and 30 healthy women as control. FSH and LH were measured using Electrochemiluminescence assay. DNA was isolated for molecular … …OnLine Journal of Biological Sciences, Vol. 18, Issue 4 · 15 Nov 2018 · 7,553 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAssociation of High-Affinity FcεRI-β intron 2 for IgE Gene Polymorphism and Atopic Diseases in an Algerian PopulationDahbia Ines Dahmani, Ikhlass Haj Salem, Jamila Chakir et al.Atopy is characterized by the production of a high level of IgE in response to common allergens. We examined the RsaI-in2 polymorphism of the FcεRI-β gene and its association with atopic asthma and comorbidity. The study population included 77 atopic asthmatics and 77 non-atopic, non-allergic and non-asthmatic controls. Atopic asthma was confirmed by the skin prick test and by IgE … …OnLine Journal of Biological Sciences, Vol. 17, Issue 4 · 1 Nov 2017 · 7,444 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe -863 TNF-α Polymorphism and Primary Open Angle Glaucoma in EgyptiansWalaa Bayoumie Abdulwahhab El Gazzar, Shaymaa Mohamed Abd El Rahman, Mohamed Nagy Elmohamady et al.Growing evidence indicates that TNF-alpha is involved in the pathogenesis of POAG in several ways, primarly by induction of retinal ganglion cells apoptosis and therefore optic nerve degeneration. TNF-alpha and POAG relationship has been studied at the genetic level with variable results in different populations. The transcription rate and the release of the TNF-alpha cytokine have been reported to be … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 2 · 1 Jun 2017 · 7,356 accessesView PDFCite
Research ArticleOpen accessEvery word in the titlePolymorphisms in Several Porcine Genes are Associated with Growth TraitsGetmantseva Lyubov, Anatoly Kolosov, Maria Leonova et al.The purpose of this study was to confirm the relation between polymorphism of POU1F1, GH, PRLR and MC4R genes and economically important traits of the Duroc pigs bred in Russia. Studies were carried out on purebred Duroc breed pigs (male n = 360). All pigs were kept under identical and standard conditions. The traits of analysis: The number of Days … …American Journal of Animal and Veterinary Sciences, Vol. 11, Issue 4 · 12 Nov 2016 · 7,415 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleStudy the Impact of T-helper 1 Cytokine (TNF-α) Polymorphisms on Susceptibility/Resistance to Brucellosis in Makkah RegionAlaa B. Ismael, Adil Mergani, Salama A-H Mostafa, Abdelmoneim M. SalimPolymorphisms in the regulatory regions of cytokine genes may not only increase susceptibility to some infectious diseases but also affect the course and prognosis of the disease. TNF-α is considered an important Th1 cytokines that plays critical roles in control of Brucella infection and in macrophage activation. In this study, we are going to analyze the relationship of two polymorphisms … …American Journal of Infectious Diseases, Vol. 12, Issue 3 · 9 Aug 2016 · 7,119 accessesView PDFCite