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7 results for “p21”
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Research ArticleOpen accessEvery word in the titleThe Interplay between p53 and p21 Tumor Suppressor Proteins in the Transformation of Colorectal Adenoma to CarcinomaA.S. Abdulamir, R.R. Hafidh, L.K. Mahdi et al.This study was carried out for evaluating the interplay of p53, p21 and Ki-67 proteins along the colorectal adenoma-carcinoma oncogenic transformation sequel. Therefore, Fifty colorectal cancer and 14 adenoma patients were involved. The histopathological expression of p53, p21 and Ki-67 proteins was evaluated by immunohistochemistry assay. The results revealed that remarkable overexpression of p53 protein was seen in the tumorous … …American Journal of Immunology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,740 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Biology of p21Waf1/Cip1 - Review PaperRenald A. Blundellp21WAF1/Cip1 belongs to the Cip/Kip family of cyclin kinase inhibitors (CKI) (p21Waf1/Cip1, p27Kip1, p57Kip1). p21Waf1/Cip1 was first described as a potent and universal inhibitor of cyclin-dependent kinases (Cdks). Two forms of functionally active p21 has been localized and described: a nuclear and a cytoplasmic forms. In this paper the structures of p21 has been described and as well as it … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 1 · 31 Mar 2006 · 7,012 accessesView PDFCite
Research ArticleOpen accessIn the abstractDihydroartemisinin Attenuates HBV-Induced Proliferation and Migration in LO2 cells via EMT Pathway ModulationYingde Nong, Caifang Ma, Wei Huang et al.Dihydroartemisinin (DHA), a derivative of artemisinin, possesses well-documented anti-inflammatory properties. This study investigated the inhibitory effects of DHA on hepatitis B virus (HBV)-induced cellular alterations in LO2 cells and elucidated underlying molecular mechanisms. Serum interleukin-6 (IL-6) levels were measured in HBV patients and analyzed for correlations with HBsAg, anti-HBs, and HBeAg. In vitro, LO2 cells were infected with clinical HBV … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 8 Jan 2026 · 2,071 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparative Effect of Ulvan and Biosynthesized Silver Nanoparticles on Different Cell Lines Cytotoxicity and Gene ExpressionHadear Hanie Amin, Mohammed Ahmed Taha AbdelreheemUntil now, researchers searching for compounds that contribute for treating the most serious disease of this age, cancer. Researchers hope to contribute to this through this research. Activities of both Ulvan extracted from Ulva lactuca and silver nanoparticles (Ag-NPs) were examined against seven different cancer cell types called (Caco2 cells, A549 cells, Mcf7 cells, Hep2 cells, HepG2 cells, PC3 cells, … …OnLine Journal of Biological Sciences, Vol. 20, Issue 2 · 30 Jun 2020 · 6,675 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvolvement of Bone Marrow Megakaryocytes in the Formation of the Bone Marrow-Blood Barrier in Transgenic MicePawel Laskowski, Karol Ostrowski, Beata Klim et al.Mature cell release takes place through the hypothetical barrier- the bone marrow-blood barrier. It consists of blood vessels and cells that surround them. Such cells are, among others, megakaryocytes. They are involved in the release of platelets or other cellular components of blood. The amount and the development of megakaryocytes and thus the maturity of barrier depends on many factors. … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 3 · 19 Sep 2013 · 7,180 accessesView PDFCite
Research ArticleOpen accessIn the abstractCryptolepine Provokes Changes in the Expression of Cell Cycle Proteins in Growing CellsCharles Ansah, Nigel J. GooderhamProblem statement: Cryptolepine, the antimalarial plant alkaloid is cytotoxic to mammalian cells, but there is rather little understanding of the possible mechanisms involved in the cell-kill action of cryptolepine. Approach: We examined mammalian cells exposed to cryptolepine (0.5-5.0 μM) for effects on the cell cycle and associated alterations in the levels of major regulatory proteins using immunoblotting and flow cytometry. … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 7,396 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Arid3a Transcription Factor Rescues Natural and RAS-V12-Induced Senescence Via a Rb-Dependent PathwayChristian Schmidt, Dongkyoon Kim, Shawn Mathur et al.Primary cells are protected against oncogenic events by undergoing premature cellular senescence—an irreversible cell cycle arrest activated by mitogenic signaling as well as by overexpression of tumor suppressors, including p16INK4A, p53 and PML. In the human, downregulation of Dril1/E2F-BP1, a transcriptional regulator of E2F, promotes PML-dependent premature senescence and bypass of ant-iproliferative signaling by p19Arf/p53/p21Cip1 and p16INK4a to prevent both … …American Journal of Immunology, Vol. 13, Issue 4 · 4 Nov 2017 · 8,396 accessesView PDFCite