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Research ArticleOpen accessPhrase in the titleCross Talk between Iron Regulatory Proteins and Proinflammatory Molecules in Ovarian Cancer Patients Based on Menopausal StatusHaritha Padannapurath Manoj, Sudha Kuthethur, Reshma Kumarchandra et al.Micronutrient iron is postulated to contribute to the initiation of cancer mainly by the formation of Reactive Oxygen Species (ROS), the key signaling molecules of inflammatory reactions. Iron may also cause elevation of MMP9, a gelatinase responsible for remodeling extracellular matrix in cancer cells through the ROS pathway. Estrogen the hormone which decreases markedly in post menopause is also known … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 31 May 2024 · 4,494 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleRetinoids Chemosensitize Ovarian Cancer Cell Lines to Cisplatin Independent of Nuclear Receptors and p53Suresh Guruswamy, Doris M. BenbrookTreatment of ovarian cancer with cisplatin-based chemotherapy is highly toxic and is often followed by cancer recurrence. Repeated treatments with cisplatin frequently result in the development of resistance to this drug. Drugs with low toxicity that could enhance the tumor cell killing effects of cisplatin could potentially reduce the toxicity and enhance the efficacy of cisplatin. The mechanism of cell … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 6,962 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleSPECTRAL DOMAIN FEATURES FOR OVARIAN CANCER DATA ANALYSISAhmed Farag Seddik, Riham Amin Hassan, Mahmoud A. FakhreldeinThe early detection of cancer is crucial for successful treatment. Medical researchers have investigated a number of early-diagnosis techniques. Recently, they have discovered that some cancers affect the concentration of certain molecules in the blood, which allows early diagnosis by analyzing the blood mass spectrum. Researchers have developed several techniques for the analysis of the mass-spectrum curve analysis and used … …Journal of Computer Science, Vol. 9, Issue 8 · 9 Jul 2013 · 6,920 accessesView PDFCite
Research ArticleOpen accessIn the keywordstNOX (ENOX2) Target for Chemosensitization-Low-Dose Responses in the Hormetic Concentration RangeD. James Morre, Sara Dick, Elena Bosneaga et al.An emerging concept of cancer chemotherapy is that of chemosensitization. Most often applied to the treatment of drug-resistance cancers, chemosensitization has utility when such cancers are rendered drug sensitive through treatment with the sensitizing agent. A particularly striking example of chemosensitization is that encountered with the synthetic isoflavene phenoxodiol where patients with taxane- and/or platinum-resistant ovarian carcinoma once again become … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,573 accessesView PDFCite
Research ArticleOpen accessIn the keywordsRisk of Second Non Breast Malignancies (SNBM) in Relation to Brca1 And Brca2 Mutation Status Following Breast-Conserving Surgery and RadiotherapyYoulia M. Kirova, Alain Fourquet, Alexia Savignoni, Brigitte Sigal-ZafraniWomen from hereditary breast cancer families with BRCA1/2 germline mutation are at increased risk for contralateral breast cancer (BC) and for ovarian cancer (OC). It is less clear whether mutation status influences the rate of SNBM other than OC. In addition, little is known on the risk of OC in individuals from hereditary BC families without identified BRCA mutation. Our … …American Journal of Immunology, Vol. 2, Issue 3 · 30 Sep 2006 · 7,230 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 13,008 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of Classification Models for Predicting Mortality Rate Using Thyroid Cancer DataNorah Saleh AlghamdiMachine Learning (ML) can potentially enhance predictions in real-life domains. This study presents an evaluation and comparison of different ML methods which can be applied on thyroid cancer dataset, called Prostate, Lung, Colorectal and Ovarian (PLCO), of approximately 155,000 participants with thyroid cancer occurrence and mortality incidence. The ML models are explored for predicting mortality rates of patients with thyroid … …Journal of Computer Science, Vol. 15, Issue 1 · 21 Jan 2019 · 7,796 accessesView PDFCite
Research ArticleOpen accessIn the abstractIs Cancer Recurrence Postponed By a Treatment? A New Model AnswersRamalingam ShanmugamDuring a treatment period of a cancer patient, the medical team ponders over a question: Is patient’s cancer recurrence significantly postponed by the medication, even if the illness is not completely cured? This question could be answered with data evidence if the data are analyzed with an appropriate model and a suitable methodology. A scanning of the literature reveals that … …Current Research in Medicine, Vol. 4, Issue 1 · 26 Mar 2013 · 6,894 accessesView PDFCite