6 articles for “non-inferiority trials”

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Research ArticleOpen accessPhrase in the titleGlobal Test for Superiority and Non-Inferiority Trials with Functional Endpoints DataArsene Brunelle Sandie, Jules Brice Tchatchueng-Mbougua, Anthony WanjoyaThe global two-sided test for functional means difference got much attention in the literary works. While the global one-sided test for functional means difference has not been studied. However, that could have some applications and implications for longitudinal trials or trials with functional data outcomes. This work introduced superiority and noninferiority hypothesis tests for functional data outcomes, which were viewed … …Current Research in Biostatistics, Vol. 9, Issue 1 · 8 Jul 2019 · 12,656 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsComparisons of Test Statistics for Noninferiority Test for the Difference between Two Independent Binominal ProportionsYouhei Kawasaki, Fanghong Zhang, Etsuo MiyaokaProblem statement: Noninferiority tests are frequently used in clinical trials to demonstrate that the response for study drugs is not much worse than the response for reference drugs. Several test statistics exist. However, a detailed comparison of those test statistics is not researched. Moreover, a little complex calculation might be necessary in some of those test statistics. Approach: In this … …Current Research in Biostatistics, Vol. 1, Issue 1 · 30 Jun 2010 · 14,098 accessesView PDF Cite

Research ArticleOpen accessIn the abstractFunctional Non-Inferiority Hypothesis Testing for Longitudinal DataArsène Brunelle Sandie, Anthony Wanjoya, Jules Brice Tchatchueng-MbouguaThe study pattern of non-inferiority trials is increasingly used to show the non-inferiority of new health intervention. Although in such studies the data are longitudinally collected (data held over a period of time), the conclusion of these non-inferiority trials is based on data observed at a specific time during the study period (usually at the end of the study period). … …Journal of Mathematics and Statistics, Vol. 15, Issue 1 · 29 Aug 2019 · 6,933 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAdaptive Superiority and Noninferiority Trial Design with Paired Binary DataMark Chang, Jing WangNon-inferiority of a diagnostic test to the standard is a common issue in medical research. For instance, we may be interested in determining if a new diagnostic test is noninferior to the standard reference test because the new test might be inexpensive to the extent that some small inferior margin in sensitivity or specificity may be acceptable. Noninferiority trials are … …Current Research in Biostatistics, Vol. 5, Issue 2 · 7 Sep 2015 · 8,236 accessesView PDF Cite

Research ArticleOpen accessIn the abstractTHREE BAYESIAN TEST INDEXES FOR NORMAL DISTRIBUTIONSYohei KawasakiIn clinical trials, data that are consistent with a normal distribution are often regarded as candidates for primary evaluation variables. In such cases, t-tests are frequently used to compare different groups of data. However, the repeated use of t-tests leads to problems with multiplicity. This study proposes three new indexes that are based on (Kawasaki and Miyaoka, 2012; 2013). These … …Journal of Mathematics and Statistics, Vol. 10, Issue 2 · 24 Apr 2014 · 6,721 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordTrial Design and Analysis with Incomplete Paired DataMark Chang, Jing WangFor a clinical trial design with paired data, it often involves missing observations. In such a case, the data from the trial become a mixture of paired and unpaired data. A commonly used approach for the analysis of the trial data is to ignore the incomplete pairs. Such a treatment of missing data is not statistically efficient. We propose a … …Current Research in Biostatistics, Vol. 5, Issue 2 · 12 Nov 2015 · 7,889 accessesView PDF Cite