5 results for “nevirapine”

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Research ArticleOpen accessEvery word in the titleNevirapine Hepatotoxicity: Implications of Risk FactorsElias Adikwu, Oputiri Deo, Oru-Bo Precious Geoffrey, D. Akuegbe EnimeyaHighly active antiretroviral therapy is used in the management of HIV/AIDS; it has contributed tremendously in the reduction of mortality and morbidity rate in HIV patients. Despite the outstanding achievement with the use of HAART its major limitation is toxicity. Among these toxicities is hepatotoxicity which is said to be associated with nevirapine containing highly active antiretroviral therapy. Recent reports … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 2 · 3 Jun 2013 · 7,653 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleConcentration-Effect, Incidence and Mechanism of Nevirapine HepatotoxicityAdikwu Elias, Brambaifa NelsonNevirapine is a dipyridozepinone non nucleoside reverse transcriptase inhibitor approved for use in HIV-infected patients. Its efficacy has been well demonstrated in numerous clinical trials. It has activity against HIV-1 but does not have significant activity against HIV-2 or other retroviruses. Nevirapine is used as one of the components of highly active antiretroviral therapy in HIV patients and in the … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 1 · 19 Apr 2013 · 8,156 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsComparative Docking Analysis on Natural Compounds Versus a Synthetic Drug as a Therapeutic for Acquired Immuno Deficiency SyndromeSandhya R. Nair, R. Subhashini, B. ThiagarajanProblem statement: Acquired Immune Deficiency Syndrome (AIDS) is one of the worst pandemics affecting and spreading quickly all over the world with a high mortality rate. AIDS has been able to kill so many people due to the unique property of Human Immunodeficiency Virus (HIV) virus. It attacks the immune system of the victim there by not allowing the immune … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 7,323 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsThe Lipid-Lowering Efficacy of Switching Within Non-Nucleoside Reverse Transcriptase Inhibitors in HIV-Infected PatientsA.M. Bain, K.D. Payne, A.P. Rahman et al.The objective of present research is to evaluate the lipid lowering efficacy and safety of switching within non-nucleoside reverse transcriptase inhibitors (NNRTI) in HIV-infected patients. This is a multicenter, retrospective study utilizing a comprehensive electronic patient registry to identify all adult HIV-infected patients seen from October 1, 1998 through October 1, 2006, who substituted efavirenz for nevirapine (EFV→NVP) or vice-versa … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 6,743 accessesView PDF Cite

Research ArticleOpen accessIn the abstractLow-Birth Weight and Pre-Term Delivery in Relation to Lopinavir/Ritonavir Use in PregnancyJorge Senise, Reisson Cruz, Ricardo Palacios et al.The toxic potential of nevirapine in pregnant women with CD4 count over 250 cells mm-3 and the unsatisfactory efficacy of nelfinavir in patients with baseline Viral Load (VL) over 100,000 copies mL-1 has prompted the use of Lopinavir/ritonavir (LPV/r) in selected situations. This study aims to assess safety of LPV/r in pregnancy. Medical records from pregnant women receiving LPV/r were … …American Journal of Infectious Diseases, Vol. 4, Issue 4 · 31 Dec 2008 · 6,954 accessesView PDF Cite