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31 results for “mycobacterium tuberculosis”
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Research ArticleOpen accessPhrase in the titleGenetic Diversity and Drug Resistance of Mycobacterium tuberculosis Complex Isolates and Nontuberculous Mycobacteria Identification from Presumptive Tuberculosis Cases in Oaxaca, MexicoNakamura-Lopez Yuko, Valencia-Carmona Oscar Daniel, Martinez-Cruz Perla Monica et al.Tuberculosis (TB) is a re-emerging health problem worldwide. In Mexico, information about genetic diversity and drug resistance of Mycobacterium Tuberculosis complex (MTBc) is limited. Samples from 463 Presumptive TB cases were tested for TB by smear, culture and PCR, from which 19.2% were identify as MTBc and 16% as nontuberculous mycobacteria. MTBc isolates were characterized by Large Sequence Polymorphisms (LSPs), … …American Journal of Infectious Diseases, Vol. 16, Issue 1 · 9 Feb 2020 · 7,159 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleUnique Characteristic Features of Mycobacterium Tuberculosis in Relation to Immune SystemRajni, Laxman S. MeenaProblem statement: Tuberculosis is a leading global mortality factor which has not been effectively controlled, with 1.7 million deaths per year and 8.9 million new cases. Aerobic microbe Mycobacterium Tuberculosis H37Rv (MTB) is the causative agent of tuberculosis. Approach: It is unique among prokaryotes due to its exceptional features contributing to its survival within the hostile environment of macrophages. Results: … …American Journal of Immunology, Vol. 7, Issue 1 · 16 Aug 2011 · 17,211 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleVirtual Screening of CPP Conjugated Peptide as QcrB BCC Protein Inhibitors of Mycobacterium tuberculosis BacteriaMuhammad Ihsan Muttaqin, Manaman Huang, Usman Sumo Friend TambunanTuberculosis is a global leading cause of death, just below COVID-19 and ranked above HIV. This disease is caused by a pathogen called Mycobacterium tuberculosis, which spreads easily through the air and is known to remain latent in most people's bodies, about a quarter of the world's population. The current problems with TB also include two main concerns: The official … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 14 Mar 2024 · 5,518 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleMycobacterium tuberculosis Complex Mutations in Drug Resistant Clinical Isolates from Southwest MexicoMartínez-Cruz Perla Mónica, Nakamura-López Yuko, Quintero-Hernández Verónica et al.Mutations in target genes have been described in Mycobacterium tuberculosis Complex (MTBc) drug resistant isolates worldwide. In Mexico, not enough information has been reported in this concern. The aim of this study was to characterize mutations related to resistance to first line drugs in MTBc isolates from Oaxaca, Mexico. MTBc isolates were identified in clinical samples from Tuberculosis (TB) patients. … …American Journal of Infectious Diseases, Vol. 17, Issue 4 · 28 Oct 2021 · 6,667 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleEfficient Production of Glycosylated and Non-Glycosylated Mycobacterium tuberculosis Antigen 85B Fused to PVX Coat Protein in Nicotiana benthamiana PlantsPablo A. González, Franco D. Puccio, Alicia M. ZeladaThe development of alternative subunit based-vaccines against tuberculosis is necessary due to variable efficiency and some security concerns of the BCG vaccine. The aim of this work was evaluate the production of the Mycobacterium tuberculosis Ag85B antigen fused to Potato Virus X Coat Protein (PVX-CP) by transient expression in Nicotiana benthamiana for subunit-based tuberculosis vaccine formulation. A codon-optimized M. tuberculosis … …American Journal of Biochemistry and Biotechnology, Vol. 14, Issue 4 · 13 Nov 2018 · 9,976 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleMolecular Genotyping of Mycobacterium tuberculosis Isolates from TurkeyBerrin Gencer, Thomas M. ShinnickTo survey the circulating strains of Mycobacterium tuberculosis in Turkey, all clinical isolates (381 patients) recovered in laboratories in six cities during one-month periods were collected and typed by IS6110-DNA fingerprinting and spoligotyping. Drug susceptibilities were also determined. About 23% of the isolates were resistant to one or more drugs and about 4% were multidrug resistant (i.e., resistant to at … …American Journal of Infectious Diseases, Vol. 1, Issue 1 · 31 Mar 2005 · 6,731 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleExogenous Re-infection by Multiple Exposures to Mycobacterium tuberculosis Contributes to Subsequent Development of Active TuberculosisDiane J. Ordway, Miguel Viveiros, Fernando A. Ventura et al.The majority of tuberculosis (TB) exists in the world’s poorest countries, where costly biosafety level three facilities for containment of infectious TB patients and diagnostic facilities are not affordable. Health care workers (HCWs), in countries with high burdens of tuberculosis (TB) are at risk of nosocomially acquired TB, as there are increased numbers of cases of TB on open hospital … …American Journal of Immunology, Vol. 1, Issue 1 · 31 Mar 2005 · 6,967 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleCirculation of Multidrug-Resistant (MDR) and Extensively Drug-Resistant (XDR) Mycobacterium Tuberculosis Strains in MexicoCarlos A. Vazquez-Chacon, Armando Martinez-Guarneros, Susana Balandrano Campos et al.Emergence of Extensively Drug-Resistant (XDR) Tuberculosis (TB) is an important public health problem worldwide. In Mexico, the extent of circulation of XDR-TB strains is unknown. Here, the drug-resistance patterns of TB isolates collected in Mexico between 2006 and 2008 were analyzed. Among 137 TB isolates, (58%) were classified as MDR exclusively, (33%) were Pre-XDR and (9%) were assigned as XDR. … …American Journal of Infectious Diseases, Vol. 10, Issue 4 · 7 Jan 2015 · 7,422 accessesView PDFCite
Research ArticleOpen accessIn the keywordsIsolation Rate and Species Distribution of Non-Tuberculous Mycobacteria From 2014-2021Tae Soung Kim, Ga Yeon Kim, Young Ki Lee, Jae Kyung KimIn Korea, the incidence of Mycobacterium tuberculosis infections has decreased; however, the incidence of lung diseases attributed to Non-Tuberculous Mycobacteria (NTM) is increasing. This study aimed to elucidate the isolation rate and distribution of NTM recently isolated at a Korean test center. Respiratory samples for acid-fast bacilli culture collected between January 2014 and December 2021 at a test center in … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 4 · 13 Nov 2023 · 4,983 accessesView PDFCite
Research ArticleOpen accessIn the keywordsDesign and Synthesis of Diaminotriazines as Anti-Tuberculosis DHFR InhibitorsArundhati C Lele, Archana Raju, M.K. Ray et al.A series of novel 2,4 diamino-s-triazine was designed as potential Mycobacterium tuberculosis (Mtb) Dihydro folate reductase inhibitors. The synthesized compounds were evaluated in whole cells by employing Resazurin Microtitre Plate Assay (REMA) against Mtb H37Rv, using known DHFR inhibitors Methotrexate and Trimethoprim as standard drugs. The most active compound in the whole cell assay was selected for DHFR enzyme assay … …Current Research in Drug Discovery, Vol. 1, Issue 2 · 26 Jan 2015 · 14,716 accessesView PDFCite