Research ArticleOpen accessPhrase in the titleDensity Functional Theory Based Quantitative Structure Activity Relationship Study of 2,5-Bis(1-Aziridinyl)-p-Benzoquinones with Lymphoid LeukemiaBahjat A. Saeed, Rita S. EliasProblem statement: QSAR techniques increase the probability of success and reduce time and coast in drug discovery process. The study presented QSAR investigation on 32 bioactive aziridinylbenzoquinones that have activity against lymphoid leukemia. Approach: Molecular descriptors, molecular weight, total energy, hardness, chemical potential, electrophilicity index, HOMO and LUMO energies were calculated. Initial geometry optimizations were carried out with the AM1 … …American Journal of Applied Sciences, Vol. 7, Issue 7 · 31 Jul 2010 · 7,211 accessesView PDFCite
Research ArticleOpen accessIn the abstractLeukemia and TherapyN. B. Alitheen, S. K. Yeap, N. H. Faujan et al.Problem statement: Leukemia is a cancer which linked intimately with the immune system. It is a group of heterogenous neoplastic disorder of white blood cells characterized by the uncontrolled proliferation and block in differentiation of hematopoeitic cells. Generally, leukemia can be classified into myeloid or lymphoid referring to the type of abnormal cell found most in the blood. Approach: Many … …American Journal of Immunology, Vol. 7, Issue 4 · 27 Feb 2012 · 8,123 accessesView PDFCite
Research ArticleOpen accessIn the abstractMolecular Mechanisms of Neurodegenerative Diseases Induced by Human Retroviruses: A ReviewBryan P. Irish, Zafar K. Khan, Pooja Jain et al.Problem statement: Infection with retroviruses such as human immunodeficiency virus type 1 (HIV-1) and human T cell leukemia virus type 1 (HTLV-1) have been shown to lead to neurodegenerative diseases such as HIV-associated dementia (HAD) or neuroAIDS and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP), respectively. Approach: HIV-1-induced neurologic disease is associated with an influx of HIV-infected monocytic cells across the blood-brain … …American Journal of Infectious Diseases, Vol. 5, Issue 3 · 30 Sep 2009 · 14,888 accessesView PDFCite
Research ArticleOpen accessIn the abstractAge Difference in Immunophenotype of Acute LeukemiaKazunori Nakase, Mary Sartor, Kenneth BradstockWe examined the immunophenotype of 880 cases with acute leukemia and analyzed their age difference in relation to the morphological subtype and the karyotype. We divided the patients into 3 age groups: child (0-15 years), adult (16-59 years) and elderly (60 years and older) group. The diagnoses based on the French-American-British (FAB) criteria and the immunophenotype as follows: 453 patients … …American Journal of Immunology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,941 accessesView PDFCite